Zheng, Zi-Qiang Jin, Ying-Wei Yin, Di Chen, Xiao He, Su-Mei Liu, Chen-Xu Zhang, Cun Wang, Dong-Dong
Published in
Frontiers in Psychiatry
Objective Bipolar affective disorder (BAD) is a mood disorder with high morbidity and mortality. Quetiapine can be used in the treatment of patients with BAD; however, the precise administration regimen of quetiapine in these patients is still unknown. In this study, a population pharmacokinetic (PPK) model of quetiapine in patients with BAD was co...
Chen, Xiao Zhang, Yue Yin, Di Jin, Ying-Wei He, Su-Mei Liu, Chen-Xu Zhang, Cun Wang, Dong-Dong
Published in
Frontiers in Pharmacology
Objective Although quetiapine has been approved for use in schizophrenic patients, its individualized dosage regimen remains unclear, especially with respect to drug–drug interactions (DDIs). Thus, we investigated the potential DDIs and optimal initial dosage of quetiapine in schizophrenic patients based on population pharmacokinetics (PPK). Method...
verbič, matej dobravc grabnar, iztok eyer, florian brvar, miran
Over the past decade, quetiapine has become one of the most commonly used psychotropic drugs in acute intoxication events worldwide. A structured literature review and analysis were conducted to assess the relationship between the kinetic and dynamic profiles in acute quetiapine intoxication. The correlation between dose and peak serum concentratio...
rose, olaf huber, sophia trinka, eugen pachmayr, johanna clemens, stephanie
Objectives: Parkinson’s disease psychosis (PDP) is a prevalent non-motor symptom associated with Parkinson’s disease. The treatment options for PDP are limited, and its pharmacological management remains ambiguous. This study aimed to evaluate the existing evidence in relation to clinical practice. Methods: This multi-methods study consisted of a s...
Jean Jacques, Amélie D’Avanzo, Nazzareno
Published in
Frontiers in Pharmacology
Quetiapine is a second-generation atypical antipsychotic drug that has been commonly prescribed for the treatment of schizophrenia, major depressive disorder (depression), and other psychological disorders. Targeted inhibition of hyperpolarization-activated cyclic-nucleotide gated (HCN) channels, which generate Ih, may provide effective resistance ...
Grabitz, Peter Saksone, Lana Schorr, Susanne Gabriele Schwietering, Johannes Bittlinger, Merlin Kimmelman, Jonathan
Published in
Clinical trials (London, England)
Researchers often conduct small studies on testing a drug's efficacy in off-label indications. If positive results from these exploratory studies are not followed up by larger, randomized, double-blinded trials, physicians cannot be sure of a drug's clinical value. This may lead to off-label prescriptions of ineffective treatments. We aim to descri...
Rajagopalan, Krithika Rashid, Nazia Yakkala, Vinod Doshi, Dilesh
Published in
ClinicoEconomics and Outcomes Research: CEOR
Background Patients with Parkinson’s disease psychosis (PDP) treated with pimavanserin (PIM) versus other atypical antipsychotics (AAPs) including quetiapine (QUE) may have health-care cost savings due to fewer skilled nursing facility-stays (SNF-stays) and long-term care admissions (LTCA). Methods A decision analytic model was developed using the ...
Breznoscakova, Dagmar Pallayova, Maria
Published in
Frontiers in Endocrinology
Introduction Type 1 diabetes mellitus is characterized by an absolute insulin deficiency requiring the lifetime intensive insulin therapy accompanied by daily self-monitoring, self-management, ongoing education, and complex diabetes care. Regular patient-clinician shared therapeutic decisions based on age, sex, comorbidities, medications, predicted...
Kong, Lingzhuo Shen, Yuting Hu, Shaohua Lai, Jianbo
Published in
CNS neuroscience & therapeutics
This study aims to investigate whether quetiapine monotherapy or in combination with lithium significantly disturbs thyroid function in depressed patients with bipolar disorder (BD), and whether difference exists in the post-treatment thyroid function between the two therapies. Based on the electric medical records, outpatients and inpatients with ...
Heng, Gerard Soh, Teck Hwee Kwok, Cecilia
Published in
Cureus
Rhabdomyolysis has been reported as a rare adverse effect of psychotropic use. This paper presents a case of rhabdomyolysis in a 39-year-old man with depression and substance use disorder. He had been started on quetiapine two months before and mirtazapine two weeks before developing symptoms of pain and weakness. His creatine kinase (CK) was eleva...
