Cui, Xiangning Zhang, Yang Lu, Yingdong Xiang, Mi
Published in
Frontiers in Pharmacology
Pulmonary diseases are main causes of morbidity and mortality worldwide. Current studies show that though specific pulmonary diseases and correlative lung-metabolic deviance own unique pathophysiology and clinical manifestations, they always tend to exhibit common characteristics including reactive oxygen species (ROS) signaling and disruptions of ...
Lin, Nancy W. Liu, Cuining Yang, Ivana V. Maier, Lisa A. DeMeo, Dawn L. Wood, Cheyret Ye, Shuyu Cruse, Margaret H. Smith, Vong L. Vyhlidal, Carrie A.
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Published in
Frontiers in Genetics
Background: Sex-specific differences in fetal lung maturation have been well described; however, little is known about the sex-specific differences in microRNA (miRNA) expression during human fetal lung development. Interestingly, many adult chronic lung diseases also demonstrate sex-specific differences in prevalence. The developmental origins of ...
Tomlinson, Owen W. Stoate, Anna L. E. Dobson, Lee Williams, Craig A.
Published in
Frontiers in Physiology
Cross-sectional studies have reported lower pulmonary and aerobic function during exercise in people with cystic fibrosis-related diabetes (CFRD) compared to non-CFRD counterparts. However, this association has yet to be longitudinally investigated. Therefore, this study examines these differences over time between people with cystic fibrosis (CF) ...
Nwankwo, L Gilmartin, D Matharu, S Donovan, J Armstrong-James, D Shah, A
Background: Instances of resistant fungal infection are rising in pulmonary disease, with limited therapeutic options. Therapeutic drug monitoring of azole antifungals has been necessary to ensure safety and efficacy but is considered unnecessary for the newest triazole isavuconazole. Aims: To characterise the prevalence of isavuconazole resistance...
Parajuli, Nirmal Kosanovic, Djuro
Published in
Frontiers in Cardiovascular Medicine
Cooney, Ashley L. Wambach, Jennifer A. Sinn, Patrick L. McCray, Paul B. Jr.
Published in
Frontiers in Genome Editing
Pulmonary surfactant is critically important to prevent atelectasis by lowering the surface tension of the alveolar lining liquid. While respiratory distress syndrome (RDS) is common in premature infants, severe RDS in term and late preterm infants suggests an underlying genetic etiology. Pathogenic variants in the genes encoding key components of ...
Gillespie, David Francis, Nick Ahmed, Haroon Hood, Kerenza Llor, Carl White, Patrick Thomas-Jones, Emma Stanton, Helen Sewell, Bernadette Phillips, Rhiannon
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Published in
International journal of chronic obstructive pulmonary disease
It has been demonstrated that antibiotic prescribing for Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) can be safely reduced in primary care when general practitioners have access to C-reactive protein (CRP) rapid testing. To investigate the factors associated with post-consultation COPD health status in patients presenting ...
Freire, Ana Paula Coelho Figueira Marçal Camillo, Carlos Augusto de Alencar Silva, Bruna Spolador Uzeloto, Juliana Souza Francisco de Lima, Fabiano Alberto Gobbo, Luis Ramos, Dionei Cipulo Ramos, Ercy Mara
Published in
Physiotherapy theory and practice
Purpose: To compare the effects of three modalities of resistance training, two using elastic components and one using conventional weight machine on peripheral muscle strength in Individuals with chronic obstructive pulmonary disease (COPD). Effects on exercise capacity, impact of disease on health status, body composition and daily level of physi...
Shanthikumar, Shivanthan Neeland, Melanie R. Saffery, Richard Ranganathan, Sarath C. Oshlack, Alicia Maksimovic, Jovana
Published in
Frontiers in Immunology
In epigenome-wide association studies analysing DNA methylation from samples containing multiple cell types, it is essential to adjust the analysis for cell type composition. One well established strategy for achieving this is reference-based cell type deconvolution, which relies on knowledge of the DNA methylation profiles of purified constituent ...
Zeidan, Bassem S Jr. Patel, Jinal K Kirk, Arielle Gonzalez, Arnoldo Khan, Imran
Published in
Cureus
Cryptogenic organizing pneumonia (COP), previously known as bronchiolitis obliterans organizing pneumonia (BOOP), is a serious lung disease that can cause significant and long-term damage to the distal respiratory tract. Here we describe an unusual case in which an adult patient with recent mycoplasma pneumonia developed worsening lower airway dise...