Published in Human reproduction (Oxford, England)
Is pubertal timing associated with risk of premenstrual disorders (PMDs) in young adulthood? Late pubertal development is associated with decreased premenstrual symptom burden and risk of PMDs in young adulthood. PMDs, including premenstrual syndrome and premenstrual dysphoric disorder, may begin during the teenage years. Few risk factors in early ...
Published in Development and psychopathology
Psychosocial acceleration theory suggests that pubertal maturation is accelerated in response to adversity. In addition, suboptimal caregiving accelerates development of the amygdala-medial prefrontal cortex circuit. These findings may be related. Here, we assess whether associations between family environment and measures of the amygdala-medial pr...
Published in Journal of clinical immunology
Improved survival in ADA-SCID patients is revealing new aspects of the systemic disorder. Although increasing numbers of reports describe the systemic manifestations of adenosine deaminase deficiency, currently there are no studies in the literature evaluating genital development and pubertal progress in these patients. We collected retrospective d...
Published in The Journal of clinical endocrinology and metabolism
The lack of sensitive and robust analytical methods has hindered the reliable quantification of estrogen metabolites in subjects with low concentrations. To establish sex-specific reference ranges for estrone (E1) and estradiol (E2) throughout life and to evaluate sex-differences using the state-of-the-art liquid chromatography tandem mass spectrom...
Published in Journal of autism and developmental disorders
Adolescence is a time of remarkable biopsychosocial change, which may be particularly challenging for youth with autism spectrum disorder (ASD), necessitating enhanced understanding and accurate assessment of pubertal maturation. The study compared physical examination to parent- and self-report measures in 200 participants (134 males and 66 female...
Published in The Journal of pediatrics
To investigate the association of preconception parental obesity (body mass index [BMI] ≥30 kg/m2) with offspring pubertal development. Among 1377 children from a prospective prebirth cohort in Boston, we examined markers of puberty (age at peak height velocity [PHV], age at menarche, self-reported pubertal development score), and adrenarche (picto...
Published in Clinical endocrinology
Investigate the gonadal hormonal function in sickle cell individuals. Sickle cell disease (SCD) is associated with delayed physical and sexual development, and it has been related to both primary testicular failure and hypothalamo-pituitary-gonadal axis abnormalities. The study of the pituitary gonadotrophin reserve was done evaluating the hormonal...
Published in Clinical epidemiology
This study investigated whether size at birth and infant growth were associated with age of indicators of pubertal development in boys and girls. We hypothesized that restricted fetal growth and accelerated infant growth lead to earlier pubertal age. In total, 15,822 boys and girls answered questionnaires half-yearly with information on pubertal de...
Published in Obesity (Silver Spring, Md.)
Objective: The aim of this study was to investigate the relationship of body mass index (BMI) with subsequent statural growth among children born in the era of the obesity epidemic. Methods: Among 18,271 children from Belarus (n=16,781, born 1996-1997) and USA (n=1,490, born 1999-2002), we used multivariable linear and ordinal logistic regression t...
Published in Journal of the Endocrine Society
Preconception behaviors and experiences of mothers and fathers can affect future offspring. Recently, our laboratory showed that alcohol-naive offspring of parents who were exposed to repeated binge alcohol during adolescence showed altered DNA methylation patterns in the hypothalamus, a brain region involved in regulation of pubertal development, ...
