Liu, Huimin Shi, Zhibin Liu, Chunguo Wang, Pengfei Wang, Ming Wang, Shida Liu, Zaisi Wei, Lili Sun, Zhenzhao He, Xijun
...
Published in
Frontiers in Microbiology
Pseudorabies viruses (PRVs) pose a great threat to the pig industry of many countries around the world. Human infections with PRV have also been reported occasionally in China. Therefore, understanding the epidemiology and evolution of PRVs is of great importance for disease control in the pig populations and humans as well. In this study, we isola...
Li, Xiaohui Su, Shanchun Zhao, Haiwen Li, Yang Xu, Xueqin Gao, Yan Sun, Dongsheng Yang, Zeyong Jin, Weilin Ke, Changbin
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Published in
Frontiers in Endocrinology
The theory holds that the anterior pituitary in mammals receives humoral regulation. Previous studies have reported that the pars distalis of the anterior pituitary of several mammalian species contains substance P-, calcitonin gene-related peptide (CGRP)-, and galanin-like immunoreactive nerve fibers, but the origins of these nerve fibers are uncl...
Jansens, Robert J. J. Marmiroli, Sandra Favoreel, Herman W.
Published in
Pathogens
The US3 serine/threonine protein kinase is conserved among the alphaherpesvirus family and represents an important virulence factor. US3 plays a role in viral nuclear egress, induces dramatic alterations of the cytoskeleton, represses apoptosis, enhances gene expression and modulates the immune response. Although several substrates of US3 have been...
Delva, Jonas L. Nauwynck, Hans J. Mettenleiter, Thomas C. Favoreel, Herman W.
Published in
Pathogens
Pseudorabies virus (PRV) is a member of the alphaherpesvirus subfamily of the herpesviruses and is the causative agent of Aujeszky’s disease in pigs, causing respiratory, neurological, and reproductive symptoms. Given the heavy economic losses associated with Aujeszky’s disease epidemics, great efforts were made to develop efficacious vaccines. One...
Wu, Fengsun Lv, Yujin Zhang, Shijun Liu, Lingling Wu, Yuchen Zhao, Pandeng Peng, Zhifeng Liu, Shengli Zhang, Zhonghua Li, Wengang
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Published in
Animals : an Open Access Journal from MDPI
Simple Summary Pseudorabies virus (PRV) is a common pathogen in multiple animal species, particularly in pigs, which is now one of the most important factors on pig husbandry loss. This study isolated a PRV variation strain HNXY and performed the etiology characterization of HNXY. Moreover, the attenuated rHNXY-∆ TK /∆ gE presented satisfactory saf...
REN, Chun-Zhi HU, Wen-Yue LI, Jun-Cheng XIE, Ying-Hong JIA, Ni-Na SHI, Jun WEI, Ying-Yi HU, Ting-Jun
Published in
The Journal of Veterinary Medical Science
Pseudorabies virus (PRV) infection leads to severe inflammatory responses and tissue damage, and many natural herbs exhibit protective effects against viral infection by modulating the inflammatory response. An ethyl acetate fraction of flavonoids from Polygonum hydropiper L . (FEA) was prepared through ethanol extraction and ethyl acetate fraction...
Wang, Yalin Wu, Hongxia Wang, Bing Qi, Hansong Jin, Zhao Qiu, Hua-Ji Sun, Yuan
Published in
Frontiers in Veterinary Science
Pseudorabies (PR), also known as Aujeszky's disease, is an acute infectious disease of pigs, resulting in significant economic losses to the pig industry in many countries. Since 2011, PR outbreaks have occurred in many Bartha-K61-vaccinated pig farms in China. The emerging pseudorabies virus (PRV) variants possess higher pathogenicity in pigs and ...
Bo, Zongyi Miao, Yurun Xi, Rui Zhong, Qiuping Bao, Chenyi Chen, Huan Sun, Liumei Qian, Yingjuan Jung, Yong-Sam Dai, Jianjun
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Published in
Veterinary Research
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is an intracellular sensor of cytoplasmic viral DNA created during virus infection, which subsequently activates the stimulator of interferon gene (STING)-dependent type I interferon response to eliminate pathogens. In contrast, viruses have developed different strategies to modulate this signalling pathway. P...
Xu, Jing-jing Gao, Fei Wu, Ji-qiang Zheng, Hao Tong, Wu Cheng, Xue-fei Liu, Yuting Zhu, Haojie Fu, Xinling Jiang, Yifeng
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Published in
Frontiers in Veterinary Science
Pseudorabies virus (PRV) is the etiological agent of Aujeszky's disease, which has caused severe economic loss in China since its re-emergence in 2011. UL46, a late gene of herpesvirus, codes for the abundant but non-essential viral phosphoproteins 11 and 12 (VP11/12). In this study, VP11/12 was found to localize inside both the nucleus and cytopla...
Ji, Chihai Wei, Yingfang Wang, Jingyu Zeng, Yuchen Pan, Haoming Liang, Guan Ma, Jun Gong, Lang Zhang, Wei Zhang, Guihong
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Published in
Viruses
Pseudorabies, also known as Aujezsky’s disease, is an acute viral infection caused by pseudorabies virus (PRV). Swine are one of the natural hosts of pseudorabies and the disease causes huge economic losses in the pig industry. The establishment of a differential diagnosis technique that can distinguish between wild-type infection and vaccinated re...
