Yoosuf, Shakira Barrett, Caitlin G. Papamichael, Konstantinos Madoff, Sarah E. Kurada, Satya Hansen, Joshua Silvester, Jocelyn A. Therrien, Amelie Singh, Prashant Dennis, Melinda
...
Published in
Frontiers in Medicine
Background Pancreatic Exocrine Insufficiency (PEI) is a possible cause of recurrent/persistent symptoms in celiac disease. Although pancreatic enzyme supplementation may be used to treat non-responsive celiac disease (NRCD) in clinical practice, clinical outcomes are variable and there is limited and low quality evidence to support this practice. T...
Szachnowicz, S Duarte, A F Nasi, A da Rocha, J R M Seguro, F B Bianchi, E T Tustumi, F de Moura, E G H Sallum, R A A Cecconello, I
...
Published in
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
The present study aims to compare the effectiveness of surgical and medical therapy in reducing the risk of cancer in Barrett's esophagus in a long-term evaluation. A prospective cohort was designed that compared Barrett's esophagus patients submitted to medical treatment with omeprazole or laparoscopic Nissen fundoplication. The groups were compar...
Zhang, Xing-Yu He, Qiang-Sheng Jing, Zhong He, Juan-Xia Yuan, Jin-Qiu Dai, Xiao-Yu
Published in
Frontiers in Pharmacology
Background: Proton pump inhibitors (PPIs) are widely used and have been linked to kidney diseases. However, the role of PPI use in the development of chronic kidney disease (CKD) remains unclear. We undertook this study to examine the association between PPI use and the subsequent risk of CKD. Methods: This is a prospective analysis of 462,421 part...
Armstrong, David Hungin, Amrit Pali Kahrilas, Peter J Sifrim, Daniel Sinclair, Paul Vaezi, Michael F Sharma, Prateek
Published in
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
Refractory reflux-like symptoms have a substantial impact on patients and healthcare providers. The aim of the survey was to qualitatively assess the needs and attitudes of practicing clinicians around the management of refractory reflux symptoms and refractory gastroesophageal reflux disease (rGERD). An International Working Group for the Classifi...
Leung, Thomas Kedzior, Sonya Moore, Kerry Bierman, Jesse Coralic, Zlatan
Published in
The Annals of pharmacotherapy
Proton pump inhibitor (PPI) continuous infusions or intermittent boluses are used for the treatment of upper gastrointestinal bleeding (UGIB). Intermittent boluses are easier to give and are of lower cost without affecting clinical outcomes. To compare the rate of rebleeding between intermittent bolus and continuous infusion PPI therapy. We perform...
Chawla, Bhavneet K Cohen, Robert E Stellrecht, Elizabeth M Yerke, Lisa M
Published in
Clinical and experimental dental research
Proton pump inhibitors, such as omeprazole and pantoprazole, are frequently prescribed for the treatment of acid reflux. However, those medications have been shown to affect a variety of physiologic processes, including bone homeostasis and the gastrointestinal microbiome. The objective of this study was to assess the relationship between proton pu...
Zhang, Lilong Chen, Chen Chai, Dongqi Li, Chunlei Kuang, Tianrui Liu, Li Dong, Keshuai Deng, Wenhong Wang, Weixing
Published in
Frontiers in Pharmacology
Objective: Immune checkpoint inhibitors (ICIs) have recently demonstrated promising performance in improving the prognosis of urological cancer patients. The goal of this meta-analysis was to determine the impact of PPI use on the clinical outcomes of urological cancer patients receiving ICI therapy. Methods: Before 6 May 2022, the eligible literat...
Kampuang, Nattida Thongon, Narongrit
Published in
Frontiers in Oncology
Disruption of small intestinal Mg2+ absorption has been reported as the underlying mechanism of proton pump inhibitor-induced hypomagnesemia (PPIH); hence, this study evaluated the expression, localization, phosphorylation, and oxidation of transient receptor potential melastatin 6 (TRPM6) and TRPM7 in the small intestine of rats subjected to PPIH....
Liu, Feng Geng, Qiang Zhao, Chen Ren, Shi-Miao Yu, Hui-Lei Xu, Jian-He
Published in
Chembiochem : a European journal of chemical biology
Baeyer-Villiger monooxygenases (BVMOs) are important biocatalysts for the enzymatic synthesis of chiral sulfoxides, including chiral sulfoxide-type proton pump inhibitors for the treatment of gastrointestinal diseases. However, native BVMOs are not yet suitable for practical application due to their unsatisfactory activity and thermostability. Alth...
Mine, Keisuke Kawashiri, Takehiro Inoue, Mizuki Kobayashi, Daisuke Mori, Kohei Hiromoto, Shiori Kudamatsu, Hibiki Uchida, Mayako Egashira, Nobuaki Koyanagi, Satoru
...
Published in
International journal of molecular sciences
(1) Background: Oxaliplatin is used as first-line chemotherapy not only for colorectal cancer but also for gastric and pancreatic cancers. However, it induces peripheral neuropathy with high frequency as an adverse event, and there is no effective preventive or therapeutic method. (2) Methods: The effects of omeprazole, a proton pump inhibitor (PPI...
