louie, ye dimitriadis, evdokia
The window of implantation (WOI) is a critical phase of the menstrual cycle during which the endometrial lining becomes receptive and facilitates embryo implantation. Drawing on findings from various branches of “omics”, including genomics, epigenomics, transcriptomics, proteomics, lipidomics, metabolomics, and microbiomics, this narrative review a...
gianazza, erica papaianni, giulia g. brocca, lisa banfi, cristina mallia, alice
Lipid droplets (LDs), highly dynamic cellular organelles specialized in lipid storage and maintenance of lipid homeostasis, contain several proteins on their surface, among which the perilipin (Plin) family stands out as the most abundant group of LD-binding proteins. They play a pivotal role in influencing the behavior and functionality of LDs, re...
klippel, claire park, jiwoon sandin, sean l. winstone, tara m. chen, xue orton, dennis singh, aranjeet hill, jonathan d. shahbal, tareq k. hamacher, emily
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For many genetic disorders, there are no specific metabolic biomarkers nor analytical methods suitable for newborn population screening, even where highly effective preemptive treatments are available. The direct measurement of signature peptides as a surrogate marker for the protein in dried blood spots (DBSs) has been shown to successfully identi...
trombetti, silvia cimbalo, alessandra grosso, michela vila-donat, pilar mañes, jordi manyes, lara
Aflatoxin B1 (AFB1) and Ochratoxin A (OTA) are considered the most important mycotoxins in terms of food safety. The aim of this study was to evaluate the hepatotoxicity of AFB1 and OTA exposure in Wistar rats and to assess the beneficial effect of fermented whey (FW) and pumpkin (P) as functional ingredients through a proteomic approach. For the e...
long, hezhou zhou, jiafu zhou, changxia xie, shuyu wang, jingling tan, minjia junyu, xu
Background/Objectives: Hepatocellular carcinoma (HCC) remains a significant global health concern, primarily due to the limited efficacy of targeted therapies, which are often compromised by drug resistance and adverse side effects. Methods: In this study, we utilized a Tandem Mass Tag (TMT)-based quantitative proteomic approach to analyze global p...
baldán-martín, montse azkargorta, mikel lapitz, ainhoa moreno, lorena ortega iloro, ibon fernández-tomé, samuel arbelaiz, ander escobes, iraide marín, alicia c. bernardo, david
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Background: The proteomic analysis of serum extracellular vesicles (EVs) could be a useful tool for studying the pathophysiology of Crohn’s disease (CD) and ulcerative colitis (UC), as well as for biomarker discovery. Aims: To characterize the proteomic composition of serum EVs in patients with CD and UC to identify biomarkers and molecular pathway...
eggers, britta stepien, jennifer reker, anne-katrin esser, svenja pfeiffer, kathy pawlas, magdalena barkovits, katalin marcus, katrin
Background: Polyunsaturated fatty acids in particular omega-3 fatty acids, such as docosahexaenoic acid (DHA), are essential nutrients and components of the plasma membrane. They are involved in various processes, including synaptic development, functionality, integrity, and plasticity, and are therefore thought to have general neuroprotective prop...
frolov, andrej shumilina, julia afshar, sarah etemadi mashkina, valeria rhomanovskaya, ekaterina lukasheva, elena tsarev, alexander sulima, anton s. shtark, oksana y. ihling, christian
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It is well known that individual pea (Pisum sativum L.) cultivars differ in their symbiotic responsivity. This trait is typically manifested with an increase in seed weights, due to inoculation with rhizobial bacteria and arbuscular mycorrhizal fungi. The aim of this study was to characterize alterations in the root proteome of highly responsive pe...
martelo-vidal, laura vázquez-mera, sara miguéns-suárez, pablo bravo-lópez, susana belén makrinioti, heidi domínguez-arca, vicente de-miguel-díez, javier gómez-carballa, alberto salas, antonio gonzález-barcala, francisco javier
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This study aims to develop a protocol for respiratory disease-associated biomarker discovery by combining urine proteome studies with urinary exosome components analysis (i.e., miRNAs). To achieve this, urine was DTT treated to decrease uromodulin, then concentrated and ultracentrifuged. Proteomic analyses of exosome-free urine were performed using...
kharrat, feras capaci, valeria conti, andrea golino, valentina campiglia, pietro balasan, nour aloisio, michelangelo licastro, danilo monasta, lorenzo caponneto, federica
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Background/Objectives: Endometrial cancer (EC) is the second most frequent gynecological malignant tumor in postmenopausal women. Pathogenic mechanisms related to the onset and development of the disease are still unknown. To identify dysregulated proteins associated with EC we exploited a combined in vitro/in silico approach analyzing the proteome...
