Højfeldt, Grith Bülow, Jacob Agergaard, Jakob Asmar, Ali Schjerling, Peter Simonsen, Lene Bülow, Jens van Hall, Gerrit Holm, Lars
Published in
The American journal of clinical nutrition
Efficacy of protein absorption and subsequent amino acid utilization may be reduced in the elderly. Higher protein intakes have been suggested to counteract this. We aimed to elucidate how habituated amounts of protein intake affect the fasted state of, and the stimulatory effect of a protein-rich meal on, protein absorption, whole-body protein tur...
LaBreck, Christopher J Trebino, Catherine E Ferreira, Colby N Morrison, Josiah J DiBiasio, Eric C Conti, Joseph Camberg, Jodi L
Published in
The Journal of biological chemistry
MinD is a cell division ATPase in Escherichia coli that oscillates from pole to pole and regulates the spatial position of the cell division machinery. Together with MinC and MinE, the Min system restricts assembly of the FtsZ-ring to midcell, oscillating between the opposite ends of the cell and preventing FtsZ-ring misassembly at the poles. Here,...
Song, Jianing Merrill, Ronald A Usachev, Andrew Y Strack, Stefan
Published in
The Journal of biological chemistry
Proper brain development and function requires finely controlled mechanisms for protein turnover and disruption of genes involved in proteostasis is a common cause of neurodevelopmental disorders. Kelch-like 15 (KLHL15) is a substrate adaptor for cullin3 (Cul3)-containing E3 ubiquitin ligases and KLHL15 gene mutations were recently described as a c...
Christiano, Romain Arlt, Henning Kabatnik, Sonja Mejhert, Niklas Lai, Zon Weng Farese, Robert V Jr Walther, Tobias C
Published in
Cell reports
Protein degradation is mediated by an expansive and complex network of protein modification and degradation enzymes. Matching degradation enzymes with their targets and determining globally which proteins are degraded by the proteasome or lysosome/vacuole have been a major challenge. Furthermore, an integrated view of protein degradation for cellul...
Tan, Hwei Ling Zeng, Yi Bing Chen, Ee Sin
Published in
International Journal of Molecular Sciences
Centromere integrity underlies an essential framework for precise chromosome segregation and epigenetic inheritance. Although centromeric DNA sequences vary among different organisms, all eukaryotic centromeres comprise a centromere-specific histone H3 variant, centromeric protein A (CENP-A), on which other centromeric proteins assemble into the ki...
Stokes, Tanner Timmons, James A. Crossland, Hannah Tripp, Thomas R. Murphy, Kevin McGlory, Chris Mitchell, Cameron J. Oikawa, Sara Y. Morton, Robert W. Phillips, Bethan E.
...
Published in
Cell Reports
Stokes et al. identify and validate a core set of genes that are regulated in proportion to the magnitude of muscle protein turnover with loading. Several of these genes correlate with muscle growth only at their 3′ or 5′ untranslated region, and a subset directly influences protein synthesis in vitro .
Meyer, Fatuma Bannert, Karen Wiese, Mats Esau, Susanne Sautter, Lea F. Ehlers, Luise Aghdassi, Ali A. Metges, Cornelia C. Garbe, Leif-A. Jaster, Robert
...
Published in
International Journal of Molecular Sciences
Liver cirrhosis is frequently accompanied by disease-related malnutrition (DRM) and sarcopenia, defined as loss of skeletal muscle mass and function. DRM and sarcopenia often coexist in cirrhotic patients and are associated with increased morbidity and mortality. The clinical manifestation of both comorbidities are triggered by multifactorial mecha...
Kepp, Kasper P
Published in
Quarterly reviews of biophysics
Darwin's theory of evolution emphasized that positive selection of functional proficiency provides the fitness that ultimately determines the structure of life, a view that has dominated biochemical thinking of enzymes as perfectly optimized for their specific functions. The 20th-century modern synthesis, structural biology, and the central dogma e...
Layer, Justin H. Christy, Michael Placek, Lindsey Unutmaz, Derya Guo, Yan Davé, Utpal P.
Published in
Molecular and Cellular Biology
The LMO2/LDB1 macromolecular complex is critical in hematopoietic stem and progenitor cell specification and in the development of acute leukemia. This complex is comprised of core subunits of LMO2 and LDB1 as well as s ingle- s tranded DNA- b inding p rotein (SSBP) cofactors and DNA-binding b asic h elix- l oop- h elix (bHLH) and GATA transcriptio...
Stead, Connor A. Hesketh, Stuart J. Bennett, Samuel Sutherland, Hazel Jarvis, Jonathan C. Lisboa, Paulo J. Burniston, Jatin G.
Published in
Proteomes
Differences in the protein composition of fast- and slow-twitch muscle may be maintained by different rates of protein turnover. We investigated protein turnover rates in slow-twitch soleus and fast-twitch plantaris of male Wistar rats (body weight 412 ± 69 g). Animals were assigned to four groups ( n = 3, in each), including a control group (0 d) ...
