Frontiers in Genetics
The protozoan Leishmania donovani, from trypanosomatids family is a deadly human pathogen responsible for causing Visceral Leishmaniasis. Unavailability of proper treatment in the developing countries has served as a major threat to the people. The absence of vaccines has made treatment possibilities to rely solely over chemotherapy. Also, reduced ...
10.1371/journal.pone.0192572 / PLoS ONE / 13 / 3 / e0192572
10.1371/journal.pone.0201826 / PLoS ONE / 13 / 8 / e0201826
Lysosomal localization of mammalian target of rapamycin complex 1 (mTORC1) is a critical step for activation of the molecule. Rag GTPases are essential for this translocation. Here, we demonstrate that Nudix-type motif 2 (NUDT2) is a novel positive regulator of mTORC1 activation. Activation of mTORC1 is impaired in NUDT2-silenced cells. Mechanistic...
Journal of biomolecular structure & dynamics
Despite the recent resolutions of the crystal structure of the chemokine receptor CXCR4 in complex with small antagonists or viral chemokine, a description at the molecular level of the interactions between the full-length CXCR4 and its endogenous ligand, the chemokine CXCL12, in relationship with the receptor recognition and activation, is not yet...
10.1371/journal.pone.0178381 / PLoS ONE / 12 / 6 / e0178381
10.1371/journal.pone.0185928 / PLoS ONE / 12 / 10 / e0185928
10.1371/journal.ppat.1005452 / PLoS Pathogens / 12 / 3 / e1005452
10.1371/journal.pgen.1006221 / PLoS Genetics / 12 / 7 / e1006221
10.1371/journal.pgen.1006474 / PLoS Genetics / 12 / 12 / e1006474