Matošević, Ana Bosak, Anita
Published in
Archives of Industrial Hygiene and Toxicology
Due to their very good chemical and proteolytic stability, ability to penetrate cell membranes, and resemblance to a peptide bond, carbamate derivatives have received much attention in recent years and got an important role in modern drug discovery and medicinal chemistry. Today, carbamates make structural and/or functional part of many drugs and p...
Heywood, Astra Lamont, Iain L
Published in
FEMS microbiology reviews
Pseudomonas aeruginosa is a Gram-negative bacterium that is commonly isolated from damp environments. It is also a major opportunistic pathogen, causing a wide range of problematic infections. The cell envelope of P. aeruginosa, comprising the cytoplasmic membrane, periplasmic space, peptidoglycan layer and outer membrane, is critical to the bacter...
Chow, Wing Donga, Prina Côté-Sergent, Aurélie Rossi, Carmine Lefebvre, Patrick Lafeuille, Marie-Hélène Hardy, Hélène Emond, Bruno
Published in
Patient preference and adherence
Purpose Darunavir, cobicistat, emtricitabine, and tenofovir alafenamide can be used as a single-tablet regimen (STR, DRV/c/FTC/TAF) or multiple-tablet regimen (MTR, DRV/c+FTC/TAF) to treat patients with human immunodeficiency virus (HIV). This study described treatment patterns and predictors of adherence among patients with HIV initiated on DRV/c/...
Kahlon, Gulbag Lira, Rogelio Masvlov, Nikolay Pompa, Emmett Brar, Nimrat Eagon, Scott Anderson, Marc O Andaya, Armann Chance, Jeff P Fejzic, Hannah
...
Published in
Bioorganic & medicinal chemistry letters
The protozoan parasite Plasmodium falciparum causes the most severe form of human malaria and is estimated to kill 400,000 people a year. The parasite infects and replicates in host red blood cells (RBCs), where it expresses an array of proteases to carry out multiple essential processes. We are investigating the function of falcilysin (FLN), a pro...
Chakrabarty, Suravi; 112085; Verhelst, Steven HL; 100754;
Caspases control regulated cell death (apoptosis), a process that is crucial in the development of multicellular organisms as well as in various diseases. In order to spatiotemporally study apoptosis, we here develop photoactivatable caspase inhibitors. These are based on cysteine-reactive acyloxymethyl ketone electrophiles connected to a peptide t...
Akaberi, Dario Chinthakindi, Praveen K Båhlström, Amanda Palanisamy, Navaneethan Sandström, Anja Lundkvist, Åke Lennerstrand, Johan
Published in
Journal of biomolecular structure & dynamics
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus and infection by ZIKV Asian lineage is known to cause fetal brain anomalies and Guillain-Barrés syndrome. The WHO declared ZIKV a global public health emergency in 2016. However, currently neither vaccines nor antiviral prophylaxis/treatments are available. In this study, we report the iden...
Ghahremanpour, Mohammad M. Tirado-Rives, Julian Deshmukh, Maya Ippolito, Joseph A. Zhang, Chun-Hui Cabeza de Vaca, Israel Liosi, Maria-Elena Anderson, Karen S. Jorgensen, William L.
Published in
ACS Medicinal Chemistry Letters
A consensus virtual screening protocol has been applied to ca. 2000 approved drugs to seek inhibitors of the main protease (Mpro) of SARS-CoV-2, the virus responsible for COVID-19. 42 drugs emerged as top candidates, and after visual analyses of the predicted structures of their complexes with Mpro, 17 were chosen for evaluation in a kinetic assay ...
Schwarzenberger, Anke Kurmayer, Rainer Martin-Creuzburg, Dominik
Published in
Frontiers in Microbiology
The harmful bloom-forming cyanobacterium Planktothrix is commonly considered to be nutritionally inadequate for zooplankton grazers, resulting in limited top-down control. However, interactions between Planktothrix and zooplankton grazers are poorly understood. The food quality of Planktothrix is potentially constrained by morphological properties ...
Mocroft, A Neesgard, B Zangerle, R Rieger, A Castagna, A Spagnuolo, V Antinori, A Lampe, F C Youle, M Vehreschild, J J
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Published in
HIV medicine
Although outcomes of antiretroviral therapy (ART) have been evaluated in randomized controlled trials, experiences from subpopulations defined by age, CD4 count or viral load (VL) in heterogeneous real-world settings are limited. The study design was an international multicohort collaboration. Logistic regression was used to compare virological and...
Richman, Douglas D
The magnitude of the morbidity and mortality inflicted upon the global population in less than 1 year has driven the inescapable conclusion that the discovery and development of effective antiviral drugs for COVID-19 are urgent and should be prioritized. The antiviral drug discovery programs that emerged for HIV and hepatitis C virus have enabled t...