Havranek, Brandon Islam, Shahidul M
Published in
Journal of biomolecular structure & dynamics
The majority of genetic variations in the human genome that lead to variety of different diseases are caused by non-synonymous single nucleotide polymorphisms (nsSNPs). Neurofibromatosis type 2 (NF2) is a deadly disease caused by nsSNPs in the NF2 gene that encodes for a protein called merlin. This study used various in silico methods, SIFT, Polyph...
Mitra, Kartik Ghanta, Prasanth Acharya, Sushank Chakrapani, Gayathri Ramaiah, Basavaraju Doble, Mukesh
Published in
Journal of biomolecular structure & dynamics
SARS-related coronaviruses poses continual threat to humanity by rapidly mutating and emerging as severe pandemic outbreaks, including the current nCoV-19 pandemic. Hence a rapid drug repositioning and lead identification strategy are required to mitigate these outbreaks. We report a pharmacophore and molecular dynamics-based approach for drug repo...
leissring, malcolm a.
More than seven decades have passed since the discovery of a proteolytic activity within crude tissue extracts that would become known as insulin-degrading enzyme (IDE). Certainly much has been learned about this atypical zinc-metallopeptidase / at the same time, however, many quite fundamental gaps in our understanding remain. Herein, I outline wh...
selvaraj, bethilda anne mariatulqabtiah, abdul razak lian, kok leong, chyan yong, chean yeah tan, wen siang
The causative agent of white tail disease (WTD) in the giant freshwater prawn is Macrobrachium rosenbergii nodavirus (MrNV). The recombinant capsid protein (CP) of MrNV was previously expressed in Escherichia coli, and it self-assembled into icosahedral virus-like particles (VLPs) with a diameter of approximately 30 nm. Extensive studies on the MrN...
kårlund, anna paukkonen, isa gómez-gallego, carlos kolehmainen, marjukka
Plant-derived protease inhibitors (PI), such as Bowman-Birk inhibitors and Kunitz-type inhibitors, have been suggested to negatively affect dietary protein digestion by blocking the activity of trypsin and chymotrypsin in the human gastrointestinal system. In addition, some PIs may possess proinflammatory activities. However, there is also scientif...
Zhang, Chun-Hui Spasov, Krasimir A. Reilly, Raquel A. Hollander, Klarissa Stone, Elizabeth A. Ippolito, Joseph A. Liosi, Maria-Elena Deshmukh, Maya G. Tirado-Rives, Julian Zhang, Shuo
...
Published in
ACS Medicinal Chemistry Letters
Non-covalent inhibitors of the main protease (Mpro) of SARS-CoV-2 having a pyridinone core were previously reported with IC50 values as low as 0.018 μM for inhibition of enzymatic activity and EC50 values as low as 0.8 μM for inhibition of viral replication in Vero E6 cells. The series has now been further advanced by consideration of placement of ...
Medjeral-Thomas, Nicholas R Troldborg, Anne Hansen, Annette G Pihl, Rasmus Clarke, Candice L Peters, James E Thomas, David C Willicombe, Michelle Palarasah, Yaseelan Botto, Marina
...
Published in
Oxford Open Immunology
Protease inhibitors influence a range of innate immunity and inflammatory pathways. We quantified plasma concentrations of key anti-inflammatory protease inhibitors in chronic haemodialysis patients with coronavirus disease 2019 (COVID-19). The samples were collected early in the disease course to determine whether plasma protease inhibitor levels ...
Zak, Krzysztof M. Bostock, Mark J. Waligorska, Irena Thøgersen, Ida B. Enghild, Jan J. Popowicz, Grzegorz M. Grudnik, Przemyslaw Potempa, Jan Ksiazek, Miroslaw
Published in
Journal of Enzyme Inhibition and Medicinal Chemistry
Mirolysin is a secretory protease of Tannerella forsythia , a member of the dysbiotic oral microbiota responsible for periodontitis. In this study, we show that mirolysin latency is achieved by a “cysteine-switch” mechanism exerted by Cys23 in the N-terminal profragment. Mutation of Cys23 shortened the time needed for activation of the zymogen from...
Dampalla, Chamandi S. Zheng, Jian Perera, Krishani Dinali Wong, Lok-Yin Roy Meyerholz, David K. Nguyen, Harry Nhat Kashipathy, Maithri M. Battaile, Kevin P. Lovell, Scott Kim, Yunjeong
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Published in
Proceedings of the National Academy of Sciences of the United States of America
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to be a serious global public health threat. The 3C-like protease (3CLpro) is a virus protease encoded by SARS-CoV-2, which is essential for virus replication. We have previously reported a series of small-molecule 3CLpro inhibitors effective for inhibiting replication...
Garreto, Laís Charneau, Sébastien Mandacaru, Samuel Coelho Nóbrega, Otávio T. Motta, Flávia N. de Araújo, Carla N. Tonet, Audrey C. Modesto, Flávia M. B. Paula, Lilian M. de Sousa, Marcelo Valle
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Published in
Frontiers in Immunology
Sjögren’s Syndrome (SS) is an autoimmune exocrinopathy characterized by the progressive damage of salivary and lacrimal glands associated with lymphocytic infiltration. Identifying new non-invasive biomarkers for SS diagnosis remains a challenge, and alterations in saliva composition reported in patients turn this fluid into a source of potential b...
