Zeng, Liang Liu, Yi-min Yang, Ning Zhang, Tao Xie, Huang
Published in
Frontiers in Molecular Biosciences
Objective: This study was conducted for investigating the functions of circular RNA circRNA_100146 (circRNA_100146) in the development of prostate cancer (PCa) and identifying the underlying mechanisms of the circRNA_100146/miR-615-5p/TRIP13 axis. Materials and Methods: Under the support of RT-PCR, the expression of circRNA_100146 in PCa cells was ...
Chang, Chun-Bi Lin, Yu-Chun Wong, Yon-Cheong Lin, Shin-Nan Lin, Chien-Yuan Lin, Yu-Han Sheng, Ting-Wen Huang, Chen-Chih Yang, Lan-Yan Wang, Li-Jen
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Published in
Frontiers in Oncology
Purpose To elucidate the usefulness of intravoxel incoherent motion (IVIM)/apparent diffusion coefficient (ADC) parameters in preoperative risk stratification using International Society of Urological Pathology (ISUP) grades. Materials and Methods Forty-five prostate cancer (PCa) patients undergoing radical prostatectomy (RP) after prostate multipa...
Ahmed, Junaid Meszaros, Attila Lazar, Tamas Tompa, Peter
Published in
Protein science : a publication of the Protein Society
Androgen receptor (AR) is a nuclear hormone receptor that regulates the transcription of genes involved in the development of testis, prostate and the nervous system. Misregulation of AR is a major driver of prostate cancer (PC). The primary agonist of full-length AR is testosterone, whereas its splice variants, for example, AR-v7 implicated in can...
Zhao, Shankun Wang, Yaoyao Wu, Weizhou Yang, Suqing Feng, Lili Tao, Fangfang Ge, Weiwei Shen, Maolei Xu, Weifang
Published in
Andrologia
Nonalcoholic fatty liver disease (NAFLD), the liver component of metabolic syndrome, is considered to be associated with high risk of prostatic diseases but a systematic review has not been conducted. Under a comprehensive review of the eligible clinical studies, a potential positive association between NAFLD and benign prostatic hyperplasia/prosta...
Meijer, Dennie Donswijk, Maarten L Bodar, Yves J L van Leeuwen, Pim J Poel, Henk G van der Vogel, Wouter V Nieuwenhuijzen, Jakko A Hendrikse, N Harry Oprea-Lager, Daniela E Vis, André N
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Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Since the introduction of radiolabeled prostate-specific membrane antigen (PSMA) PET/CT, the ability to visualize recurrent prostate cancer has improved substantially. However, diagnostic accuracy is largely lacking for radiolabeled PSMA PET/CT in patients with biochemical persistence (BCP; that is, persistently measurable prostate-specific antigen...
Azhar, Raed A Aldousari, Saad Alghamdi, Musab M Alotaibi, Mohammed F Alkhateeb, Sultan S Nassir, Anmar M Alshaalan, Abdullah Yaiesh, Said Rabah, Danny
Published in
Journal of endourology
Purpose: To present multinational experience in robot-assisted radical prostatectomy (RARP) by fellowship-trained expertise in low-volume regions in Gulf Cooperation Council (GCC) countries and to compare the current results with global outcomes reported in recent meta-analyses. Methods: A retrospective review of prospectively collected data was pe...
Spethmann, Tanja Böckelmann, Lukas Clemens Labitzky, Vera Ahlers, Ann-Kristin Schröder-Schwarz, Jennifer Bonk, Sarah Simon, Ronald Sauter, Guido Huland, Hartwig Kypta, Robert
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Published in
Molecular oncology
Both oncogenic and tumor suppressor functions have been described for junction plakoglobin (JUP), also known as γ-catenin. To clarify the role of JUP in prostate cancer, JUP protein expression was immunohistochemically detected in a tissue microarray containing 11 267 individual prostatectomy specimens. Considering all patients, high JUP expression...
Sigorski, Dawid Gulczyński, Jacek Sejda, Aleksandra Rogowski, Wojciech Iżycka-Świeszewska, Ewa
Published in
Frontiers in Oncology
Background Cancer stroma contains the neural compartment with specific components and action. Neural microenvironment processing includes among others axonogenesis, perineural invasion (PNI), neurosignaling, and tumor cell neural/neuroendocrine differentiation. Growing data suggest that tumor-neural crosstalk plays an important function in prostate...
Stuparu, Andreea D Capri, Joseph R Meyer, Catherine A L Le, Thuc M Evans-Axelsson, Susan L Current, Kyle Lennox, Mark Mona, Christine E Fendler, Wolfgang P Calais, Jeremie
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Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) is effective against prostate cancer (PCa), but all patients relapse eventually. Poor understanding of the underlying resistance mechanisms represents a key barrier to development of more effective RLT. We investigate the proteome and phosphoproteome in a mouse model of PC...
Acidereli, Hilal Turut, Fatma Aysun Cevik, Ozge
Published in
Cell biochemistry and function
Interferon regulatory factor-5 (IRF5) is a transcription factor and has essential cellular mechanisms as a tumour suppressor gene. IRF5 protein function is irregular in various human cancers, and its role in prostate cancer is also unknown. This study presents the first evidence that IRF5 expression is controlled with androgen receptor (AR) signall...
