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Saleem, Muhammad Zubair Alshwmi, Mohammed Zhang, He Din, Syed Riaz Ud Nisar, Muhammad Azhar Khan, Muhammad Alam, Shahid Alam, Gulzar Jin, Lingling Ma, Tonghui
...
Published in
Frontiers in Pharmacology
Breast cancer is the most heterogenous cancer type among women across the world. Despite concerted efforts, breast cancer management is still unsatisfactory. Interplay between apoptosis and autophagy is an imperative factor in categorizing therapeutics for cancer treatment. Proscillaridin A (PSD-A), a well-known cardiac glycoside used for cardiac a...
Winnicka, Katarzyna Bielawski, Krzysztof Bielawska, Anna
Published in
Pharmacological Reports
The objective of this study was to determine the cytotoxicity, antiproliferative activity, and apoptosis induction activity of two modified glycosides - digoxin and proscillaridin A - conjugated to a generation 3 polyamidoamine dendrimer (G3 PAMAM-NH2) in human breast cancer cells. The results suggest that conjugation with the G3 PAMAM-NH2 dendrime...
