O’Sullivan, M. J. Jang, J. H. Panariti, A. Bedrat, A. Ijpma, G. Lemos, B. Park, J. A. Lauzon, A. M. Martin, J. G.
Published in
Frontiers in Physiology
The increased mass of airway smooth muscle (ASM) in the airways of asthmatic patients may contribute to the pathology of this disease by increasing the capacity for airway narrowing. Evidence for the airway epithelium as a participant in ASM remodeling is accruing. To investigate mechanisms by which airway epithelial cells induce ASM cell (ASMC) pr...
Chen, Changyu Zheng, Qiang Pan, Shubo Chen, Wenzheng Huang, Jianfeng Cao, Yi Tu, Yi Li, Zhengrong Yu, Changjun Jie, Zhigang
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Published in
Frontiers in Oncology
Worldwide, the incidence rate of gastric cancer ranks fifth, and the mortality rate of gastric cancer ranks third among all malignant tumors. However, the pathogenesis of gastric cancer remains poorly understood. In this study, we demonstrated that the expression level of NELFE is higher in human gastric cancer tissues than in adjacent nontumor tis...
Shi, Wen Zheng, Yan Luo, Shuai Li, Xiaofeng Zhang, Yilong Meng, Xiaoming Huang, Cheng Li, Jun
Published in
Frontiers in Medicine
Rheumatoid arthritis (RA), a common autoimmune disease, is extremely damaging to human health. Fibroblast-like synoviocytes (FLSs) have a vital role in the occurrence and development of RA. Methyltransferase-like 3 (METTL3), which is a crucial component of the N6-methyladenosine (m6A) methyltransferase complex, is involved in the progression of man...
Liu, Menghan Yang, Lin Liu, Xiaojun Nie, Ziyuan Zhang, Xiaoyan Lu, Yaqiong Pan, Yuxia Wang, Xingzhe Luo, Jianmin
Published in
Frontiers in Oncology
RNA binding proteins act as essential modulators in cancers by regulating biological cellular processes. Heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1), as a key member of the heterogeneous nuclear ribonucleoproteins family, is frequently upregulated in multiple cancer cells and involved in tumorigenesis. However, the function of HNRNPH1 in c...
Ding, Wenzhou Fan, Ye Jia, Wenbo Pan, Xiongxiong Han, Guoyong Zhang, Yao Chen, Zhiqiang Lu, Yiwei Wang, Jinyi Wu, Jindao
...
Published in
Frontiers in Oncology
Objectives Feline sarcoma-related protein (FER) is known to play a critical regulatory role in several carcinomas. However, the exact biological function of FER in hepatocellular carcinoma (HCC) still needs to be investigated. The primary objective of this research was to investigate the unknown function and molecular mechanisms of FER in HCC. Mate...
Liu, Aimin Zhang, Buxin Zhao, Wei Tu, Yuanhui Wang, Qingxing Li, Jing
Published in
Experimental dermatology
Psoriasis is a chronic inflammatory disease characterized by abnormal hyperproliferation and differentiation. The object of this study is to explore the role of microRNA-215-5p in psoriasis-like inflammation. The expression of miR-215-5p was found to be down-regulated in pro-inflammatory factor-stimulated HaCaT cells and imiquimod (IMQ)-treated ski...
Zhao, Yanran Cai, Curtis Samir, Jerome Palgen, Jean-Louis Keoshkerian, Elizabeth Li, Hui Bull, Rowena A Luciani, Fabio An, Hongyan Lloyd, Andrew R
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Published in
European journal of immunology
Long-lived T-memory stem cells (TSCM ) are key to both naturally occurring and vaccine-conferred protection against infection. These cells are characterized by the CD45RA+ CCR7+ CD95+ phenotype. Significant heterogeneity within the TSCM population is recognized, but distinguishing surface markers and functional characterization of potential subsets...
Li, H Cui, D Zheng, L Zhou, Y Gan, L Liu, Y Pan, Y Zhou, X Wan, M
Published in
Journal of dental research
Enamel formation is a serial and complex biological process, during which related genes are expressed progressively in a spatiotemporal manner. This process is vulnerable to environmental cues, resulting in developmental defects of enamel (DDE). However, how environmental factors are biologically integrated during enamel formation is still poorly u...
Ghasemi, Maryam Alizadeh, Effat Motlagh, Behzad Fallahi Zarghami, Nosratollah
Published in
Cell biochemistry and function
Retinoblastoma is known as childhood rare malignancy of the retina. Ciliary neurotrophic factor (CNTF) was previously found to reduce degeneration and promote retina survival. This work investigated the effects of CNTF supplementation on in-vitro model cells including retinoblastoma (Y79) and adipose-derived mesenchymal stem cells (AMSCs) viability...
Wan, Qi Liu, Fang Zhang, Jie Chen, Hui Yan, Lianqi Li, Xiaolei Sun, Yu Wang, Jingcheng
Published in
Connective tissue research
Aim: Pathologic hyperplasia of fibroblast is responsible for the progression of intraarticular fibrosis. Laminin α4 (LAMA4), a subunit of laminin macromolecule family, was found to be overexpressed in various fibrotic tissues. However, the role of LAMA4 in knee arthrofibrosis remains elusive. Therefore, the aim of this study was to investigate the ...
