Wu, Junfu Cui, Meng Wang, Jiheng Fan, Jie Liu, Shanting Lou, Weihua
Published in
Biotechnology & genetic engineering reviews
Hypopharyngeal squamous cell carcinoma (HSCC) is a highly invasive and fatal tumor with a poor prognosis in head and neck tumors. It is urgent to further study the molecular mechanism of HSCC progression and identify new effective therapeutic targets. Cell division cycle-related protein 3 (CDCA3) was reported overexpressed in several cancers and in...
Bernardo, Teresa Heuchel, Lena Heinzelmann, Feline Esser, Johannes Lüdemann, Lutz Timmermann, Beate Lühr, Armin von Neubeck, Cläre
Published in
Physics in Medicine & Biology
Objective. The energy deposition of photons and protons differs. It depends on the position in the proton Bragg peak (BP) and the linear energy transfer (LET) leading to a variable relative biological effectiveness (RBE). Here, we investigate LET dependent alterations on metabolic viability and proliferation of sarcoma and endothelium cell lines fo...
Mollazadeh, Samaneh Saeedi, Nikoo Al-Asady, Abdulridha Mohammed Ghorbani, Elnaz Khazaei, Majid Ryzhikov, Mikhail Avan, Amir Hasanian, Seyed Mahdi
Published in
Current pharmaceutical design
Hepatocellular carcinoma (HCC) is influenced by several factors, among which genetic polymorphisms play a key role. Polymorphisms in various genes affect key pathways involved in HCC development, including metabolism, expression of inflammatory cytokines, cell proliferation, and apoptosis regulation. These polymorphisms induce differential effects ...
Cai, Xiaodan Padilla, Nicole T. Rosbe, Kristina Tugizov, Sharof M.
Published in
Journal of Virology
While human cytomegalovirus (HCMV) is frequently detected in the breast milk of HCMV-seropositive women and is often transmitted to infants via breastfeeding, the mechanisms by which this transmission occurs remain unclear. In this study, we modeled HCMV transmission at the oropharyngeal mucosa. We treated human monocytes with breast milk to mimic ...
Liu, Weipeng Huang, Fengdan Yao, Yueting Liang, Yan Yan, Zhiling Guo, Lili Zhang, Xinwen Shi, Li Yao, Yufeng
Published in
Frontiers in Oncology
Background Cervical cancer stands as one of the leading causes of cancer-related mortality in women worldwide, yet the precise functions of host genes implicated in its pathogenesis remain elusive. Genome-wide association studies (GWAS) have revealed a significant association between the CLPTM1L locus and cervical cancer risk in European women, and...
Cai, Jianya Cheng, Hongwei Xu, Shuangta
Published in
Frontiers in Oncology
Alpha beta hydrolase domain containing 5 (ABHD5) is an essential coactivator of adipose triglyceride lipase (ATGL), a rate-limiting enzyme in various cell types that promotes the hydrolysis of triacylglycerol (TG) into diacylglycerol (DG) and fatty acid (FA). It acts as a critical regulatory factor in cellular lipid metabolism. The reprogramming of...
Subramani, Ramadevi Chatterjee, Animesh Pedroza, Diego A. Poudel, Seeta Rajkumar, Preetha Annabi, Jeffrey Penner, Elizabeth Lakshmanaswamy, Rajkumar
Published in
Frontiers in Oncology
Background Triple-negative breast cancer (TNBC) is a subtype of breast cancer with no effective targeted treatment currently available. Estrogen and its metabolites influence the growth of mammary cancer. Previously, we demonstrated the anti-cancer effects of 2-methoxyestradiol (2ME2) on mammary carcinogenesis. Materials and methods In the present ...
Huang, Wenming Yue, Yu Hao, Weifeng Zhang, Zhenan Cai, Pengcheng Yang, Deqin
Published in
Stem cell reports
Mammalian target of rapamycin (mTOR) serves as the key sensor to control protein synthesis, cell growth, and survival. Despite mTOR is reported to regulate hematopoietic stem and progenitor cell (HSPC) engraftment and multiple-lineage hematopoiesis in mice, the roles of unique mTOR complexes (mTORCs) in early HSPC development and HSPC pool formatio...
Zhang, Huan Ji, Hongliang Liu, Caiyun
Published in
Frontiers in Microbiology
Introduction Chaetomium subaffine LB-1 is a novel biocontrol strain that produces non-volatile metabolites that inhibit the growth of Botrytis cinerea. However, the specific metabolites and antimicrobial mechanism of the strain LB-1 remains unclear. Methods In this study, the antifungal substances produced by strain LB-1, as well as the underlying ...
Xie, Zechen Yun, Yang Yu, Ge Zhang, Xin Zhang, Hao Wang, Tian Zhang, Lili
Published in
Journal of the science of food and agriculture
The intestine is a barrier resisting various stress responses. Intrauterine growth restriction (IUGR) can cause damage to the intestinal barrier via destroying the balance of intestinal epithelial cells' proliferation and apoptosis. Bacillus subtilis has been reported to regulate intestinal epithelial cells' proliferation and apoptosis. Thus, the p...
