Liu, Zhixin Ma, Teng Duan, Jufeng Liu, Xiaofei Liu, Long
Published in
Molecular medicine reports
The tumour suppressor gene F‑box and WD repeat domain‑containing 7 (FBXW7) plays an important role in human cancer by regulating cell division, proliferation and differentiation. However, the exact regulatory mechanisms of microRNA (miR)‑223 in colorectal cancer (CRC) cells are still unknown. The present study aimed to investigate the effect and me...
Zhong, Guanglei Fang, Xingyu Xie, Qingsheng Wang, Yuhan Lin, Zhongqiu Lin, Rongchun Yao, Tingting
Published in
Oncology letters
A majority of cervical cancers are squamous cell carcinomas, arising from the squamous (flattened) epithelial cells that line the cervix. Long noncoding RNAs (lncRNAs) are a unique class of messenger RNA-like transcripts of at least 200 nucleotides in length with no significant protein-coding capacity. Aberrant lncRNA expression is emerging as a ma...
Han, Anna Xu, Ran Liu, Ying Yin, Xianglin Lin, Zhenhua Yang, Wanshan
Published in
OncoTargets and therapy
Background Pancreatic cancer (PC) is a leading cause of cancer mortality worldwide. Hydroxysteroid dehydrogenase like protein 2 (HSDL2) is overexpressed in a variety of malignant tumors and is might be closely related to the development of cancer. It also regulates different metabolism and signaling pathways. Purpose The purpose of this research wa...
Mao, Hongli Sheng, Jinxiu Jia, Jinlin Wang, Chang Zhang, Shanfeng Li, Hongle He, Fucheng
Published in
OncoTargets and therapy
Background Solute carrier family 6 member 14 (SLC6A14) is a high-capacity amino acid transporter in mammalian cells. It has gained increasing attention for its potential involvement in the progression and metabolic reprogramming of various malignant tumors. However, the role of SLC6A14 in colorectal cancer (CRC) remains unclear. Methods Real-time p...
Li, Rui-zhe Li, Yun-yun Qin, Hui Li, Shan-shan
Published in
OncoTargets and therapy
Background ACTL6A, a regulatory subunit of ATP-dependent chromatin-remodeling complexes SWI/SNF, has been identified as a central oncogenic driver in many tumor types. Materials and Methods We used immunohistochemistry (IHC) to detect ACTL6A expression in esophageal squamous cell carcinoma (ESCC) tissues. Then, the effect of ACTL6A on proliferation...
Rong, Jia-hui Li, Dong Li, Yu-liang
Published in
OncoTargets and therapy
Introduction In recent years, radioactive 125I seed implantation combined with chemotherapy has been regarded as a safe and effective treatment for advanced non-small cell lung cancer (NSCLC). However, the mechanism underlying this success is still unclear. Methods In this study, we investigated the apoptosis and anti-proliferative effect induced b...
Chen, Maojian Xiao, Chanchan Jiang, Wei Yang, Weiping Qin, Qinghong Tan, Qixing Lian, Bin Liang, Zhijie Wei, Changyuan
Published in
Drug Design, Development and Therapy
Background As a natural compound extracted from a variety of hot peppers, capsaicin has drawn increasing attention to its anti-cancer effects against multiple human cancers including breast cancer. FBI-1 is a major proto-oncogene negatively regulating the transcription of many tumor suppressor genes, and plays a vital role in tumorigenesis and prog...
Clark, Lyles R. Yun, Sanghee Acquah, Nana K. Kumar, Priya L. Metheny, Hannah E. Paixao, Rikley C. C. Cohen, Akivas S. Eisch, Amelia J.
Published in
Frontiers in Neuroscience
Mild traumatic brain injuries (mTBIs) are prevalent worldwide. mTBIs can impair hippocampal-based functions such as memory and cause network hyperexcitability of the dentate gyrus (DG), a key entry point to hippocampal circuitry. One candidate for mediating mTBI-induced hippocampal cognitive and physiological dysfunction is injury-induced changes i...
Wang, Yirong Yang, Lei Yang, Yan Li, Yulin
Published in
Cancer Management and Research
Objective To study the effect and potential mechanism of LKB1 on non-small cell lung cancer (NSCLC) A549 cells. Material and Methods A549 cells were divided into control group, LKB1 negative control (NC) group, LKB1 group, ERK inhibitor group and LKB1 + ERK activator group. Cell proliferation and apoptosis were detected by cell counting kit (CCK-8)...
Wu, Jingkui Lin, Qisheng Li, Shu Shao, Xinghua Zhu, Xuying Zhang, Minfang Zhou, Wenyan Ni, Zhaohui
Published in
Frontiers in Genetics
Immunoglobulin A nephropathy (IgAN) is a known cause of end-stage kidney disease, but the pathogenesis and factors affecting prognosis are not fully understood. In the present study, we carried out weighted gene correlation network analysis (WGCNA) to identify hub genes related to the occurrence of IgAN and validated candidate genes in experiments ...
