Chen, Xi Zhu, Ying Song, Chengchuang Chen, Yaqi Wang, Yanhong Lai, Min Zhang, Chunlei Fang, Xingtang
Published in
Animal biotechnology
MiR-424-5p was found to be a potential regulator in the proliferation, migration, and invasion of various cancer cells. However, the effects and functional mechanism of miR-424-5p in the process of myogenesis are still unclear. Previously, using microRNA (miRNA) sequencing and expression analysis, we discovered that miR-424-5p was expressed differe...
Bharati, Jaya Kumar, Satish Kumar, Sunil Mohan, N H Islam, Rafiqul Pegu, Seema Rani Banik, Santanu Das, Bikash Chandra Borah, Sanjib Sarkar, Mihir
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Published in
Animal biotechnology
Luteal steroidogenesis is critical to implantation and pregnancy maintenance in mammals. The role of androgen receptors (AR) in the progesterone (P4) producing luteal cells of porcine corpus luteum (CL) remains unexplored. The aim of the present study was to establish AR gene knock out (KO) porcine luteal cell culture system model by CRISPR/Cas9 ge...
Deng, Zhisheng Li, Lihua
Published in
Vascular
Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease. microRNAs (miRNAs) are widely distributed in the human body and closely related to the pathological progress of AS. This study probed into the function of miR-663 in AS. The atherosclerotic plaques, cholesterol (CHOL), low-density...
He, Mingliang Zhang, Weibo Wang, Shan Ge, Ling Cao, Xiukai Wang, Shanhe Yuan, Zehu Lv, Xiaoyang Getachew, Tesfaye Mwacharo, Joram M
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Published in
Animal biotechnology
This study aimed to understand the expression level of YAP1 in the skeletal muscle of Hu sheep and to reveal the regulatory mechanism of YAP1 on Hu sheep skeletal muscle satellite cells (SMSCs). Previous research by our group has found that YAP1 may affect the growth and development of Hu sheep skeletal muscle. In the present study, we found the ex...
Meng, Fanming Han, Luyang Liang, Qin Lu, Shanshan Huang, Yanqing Liu, Junwen
Published in
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists
LncRNA-Atherosclerotic plaque pathogenesis-associated transcript (APPAT) could be detected in circulating blood and has been demonstrated to correlate with the development of atherosclerosis in our previous work. It could be a potential noninvasive biomarker for earlier diagnoses of clinical cardiovascular disease. Moreover, the expression of miR-6...
Song, Chengchuang Wang, Qi Qi, Qi Chen, Xi Wang, Yanhong Zhang, Chunlei Fang, Xingtang
Published in
Animal biotechnology
MircoRNAs (miRNAs) play an important role in skeletal muscle development. Previous study had found that miR-495-3p was differentially expressed in fetal and adult goat skeletal muscle, but its function in myogenic proliferation and differentiation are unclear. Herein, we found the expression of miR-495-3p in C2C12 was downregulated during prolifera...
Chen, Dingshuang Wang, Ruilong Sheng, Xueqing Zhao, Nan Lin, Yaqiu Wang, Yong Zhu, Jiangjiang Li, Yanyan
Published in
Animal biotechnology
PDZK1-interacting protein 1(PDZK1IP1), also known as MAP17, is encoded by the PDZK1IP1 gene and is a membrane-associated protein. PDZK1IP1 have been proven to be a potent regulator of cancer cell proliferation. However, the role of PDZK1IP1 in regulating goat subcutaneous preadipocyte proliferation is unknown. Here, we cloned the full-length coding...
Sun, Bo Reynolds, Kurt Saha, Subbroto Kumar Zhang, Shuwen McMahon, Moira Zhou, Chengji J
Published in
Birth defects research
In addition to genomic risk variants and environmental influences, increasing evidence suggests epigenetic modifications are important for orofacial development and their alterations can contribute to orofacial clefts. Ezh2 encodes a core catalytic component of the Polycomb repressive complex responsible for addition of methyl marks to Histone H3 a...
Komosa, Elizabeth R Lin, Wei-Han Mahadik, Bhushan Bazzi, Marisa S Townsend, DeWayne Fisher, John P Ogle, Brenda M
Published in
Biofabrication
While the field of tissue engineering has progressed rapidly with the advent of 3D bioprinting and human induced pluripotent stem cells (hiPSCs), impact is limited by a lack of functional, thick tissues. One way around this limitation is to 3D bioprint tissues laden with hiPSCs. In this way, the iPSCs can proliferate to populate the thick tissue ma...
Kolesarova, Adriana Baldovska, Simona Kohut, Ladislav Vasicek, Jaromir Ivanisova, Eva Arvay, Julius Duracka, Michal Roychoudhury, Shubhadeep
Published in
Frontiers in Endocrinology
In this study, response of ovarian cells (human granulosa cell line HGL5, and human adenocarcinoma cell line OVCAR-3) to short-term pomegranate peel extract (PPE) treatment (for 24 hours in cell culture) was evaluated in vitro. Quantitative and qualitative screening of polyphenols revealed punicalagins α and β as major polyphenolic components. Tota...
