Wang, Qing Chen, Shengzhou Wu, Zhihong Ni, Jungang
Published in
Frontiers in Oncology
Background While Heat Shock Protein 60 (HSP60) has been linked to human tumor, its clinic significance specifically in breast carcinoma is unclear. This investigation aims to retrospectively evaluate how HSP60 protein levels relate to survival outcomes among patients diagnosed with breast carcinoma. Methods Evaluation of 206 patients diagnosed with...
Xu, Fang-Zhou Meng, Fu-Rong Li, Wan-Jing Xu, Lu Zhang, Hao Zhang, Yan-Bei Fan, Xiao-Yun
Published in
Open Life Sciences
The aim of this study is to assess the impact of serum magnesium (Mg) levels on prognostic outcomes in patients with non-small cell lung cancer (NSCLC) undergoing treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). A cohort comprising 91 patients with NSCLC with epidermal growth factor receptor mutations received ...
Ackerman, Benjamin Gan, Ryan W. Meyer, Craig S. Wang, Jocelyn R. Zhang, Youyi Hayden, Jennifer Mahoney, Grace Lund, Jennifer L. Weberpals, Janick Schneeweiss, Sebastian
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Published in
Frontiers in Drug Safety and Regulation
Introduction: While randomized controlled trials remain the reference standard for evaluating treatment efficacy, there is an increased interest in the use of external control arms (ECA), namely in oncology, using real-world data (RWD). Challenges related to measurement of real-world oncology endpoints, like progression-free survival (PFS), are one...
Schoffski, P.; 46480; Jones, R.L.; Agulnik, M.; Blay, J.Y.; Chalmers, A.; Italiano, A.; Pink, D.; Stacchiotti, S.; Valverde, C.; Vincenzi, B.;
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BACKGROUND: Locally advanced (unresectable) or metastatic dedifferentiated liposarcoma (DDLPS) is a common presentation of liposarcoma. Despite established diagnostic and treatment guidelines for DDLPS, critical clinical gaps remain driven by diagnostic challenges, symptom burden and the lack of targeted, safe and effective treatments. The objectiv...
Zeng, Qiang Tian, Zhongyu Dong, Fei Shi, Feina Xu, Penglei Zhang, Jianmin Ling, Chenhan Guo, Zhige
Published in
Frontiers in Oncology
Aim This study aims to investigate the potential value of radiomic features from multi-parameter MRI in predicting progression-free survival (PFS) of patients with WHO grade II meningiomas. Methods Kaplan–Meier survival curves were used for survival analysis of clinical features. A total of 851 radiomic features were extracted based on tumor region...
McKinley, Blake J. Pai, Tanmayi S. Wolf, Emily B. Li, Shenduo Correia, Guilherme Sacchi de Camargo Zhao, Yujie Manochakian, Rami Lou, Yanyan
Published in
Frontiers in Oncology
Introduction Limited survival data are available for patients with metastatic non-small cell lung cancer (mNSCLC) who stop immune checkpoint inhibitor therapy (ICI) early for reasons other than progression of disease (POD), such as immune-related adverse events (irAEs). Methods We conducted a retrospective observational study of all patients with m...
Tang, Min Wang, Yue Li, Pulin Han, Rui Wang, Ran
Published in
Frontiers in Pharmacology
Background Poly (ADP-Ribose) Polymerase (PARP) inhibitors represent a novel class of drugs that hinder DNA repair mechanisms in tumor cells, leading to cell death. This systematic review aims to evaluate the effectiveness, safety, and potential adverse effects of PARP inhibitors (PARPi) in the management of patients with advanced lung cancer. Mater...
Zhen, Song Hao, Chen Yanhang, Yu Yuxin, Lin Jun, Ouyang Zhiyu, Zhang
Published in
Frontiers in Oncology
Objective To compare the differential therapeutic effects of Bacillus Calmette-Guérin (BCG) instillation and radical cystectomy (RC) for high-risk non-muscle–invasive urothelial cancer (NMIBC) classified as high-grade T1 in initial and repeat transurethral resection of bladder tumors (TURBT) and to construct a prediction model. Methods We retrospec...
Wang, Yizhou Shang, Peipei Xu, Chang Dong, Wei Zhang, Xiaofeng Xia, Yong Sui, Chengjun Yang, Cheng
Published in
Frontiers in Pharmacology
Introduction: Genomic profiling has revolutionized therapeutic interventions and the clinical management of liver cancer. However, pathogenetic mechanisms, molecular determinants of recurrence, and predictive biomarkers for first-line treatment (anti-PD-(L)1 plus bevacizumab) in liver cancer remain incompletely understood. Materials and methods: Ta...
Hou, Shufu Song, Dandan Zang, Yelei Hao, Ruiqi Li, Linchuan Zhu, Jiankang
Published in
Frontiers in Oncology
Objectives The prognostic relevance of the platelet-to-lymphocyte ratio (PLR) in gastric cancer (GC) patients undergoing immune checkpoint inhibitor (ICI) treatment remains unclear. This meta-analysis aimed to determine the prognostic impact of PLR in this specific patient cohort. Methods We searched the PubMed, Cochrane Library, CNKI, and EMBASE d...
