Disease progression in myeloproliferative neoplasms: comparing patients in accelerated phase with those in chronic phase...
...Published in Haematologica
Copyright © 2019, Ferrata Storti Foundation.
Impact of classifying keratoconus location based on keratometry or pachymetry on progression parameters.
Published in Clinical & experimental optometry
This study sought to assess the impact of classifying keratoconus location based on thinnest pachymetry or maximum keratometry (Kmax) on progression parameters after corneal crosslinking (CXL). In this observational study, patients were followed up at one, three, six and 12 months after CXL. All patients underwent visual acuity, Scheimpflug tomogra...
Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma
...
Hyponatremia has been shown to be associated with prognosis in various cancers, but its role in upper tract urothelial carcinoma (UTUC) is largely unidentified. We created an international multiregional cohort of UTUC, consisting of 524 and 213 patients from Taiwan and the U.S., to validate the significance of hyponatremia. Clinicopathologic charac...
FOXK1 Promotes Proliferation and Metastasis of Gallbladder Cancer by Activating AKT/mTOR Signaling Pathway
Published in Frontiers in Oncology
Gallbladder cancer (GBC) is one of the most lethal malignancies worldwide, with extremely poor prognosis. Recently, forkhead box k1 (FOXK1), a member of the FOX transcription factor family, has been reported to be correlated with tumor progression in multiple malignancies. However, the role of FOXK1 in GBC has not been elucidated. In this study, we...
Role of the E3 Ubiquitin Ligase TRIM4 in Predicting the Prognosis of Hepatocellular Carcinoma
Published in Journal of Cancer
The E3 ubiquitin ligase TRIM4 has been reported to regulate the assembly of the antiviral signalling complex, induce mitochondrial aggregation and sensitize cells to H2O2-induced death. However, the relationship between TRIM4 and human malignancies, including hepatocellular carcinoma (HCC), is unclear. In this study, we detected the expression of T...
CircRNA hsa_circ_0087862 Acts as an Oncogene in Non-Small Cell Lung Cancer by Targeting miR-1253/RAB3D Axis
Published in OncoTargets and therapy
Purpose Circular RNAs (circRNAs) have been found to regulate several human tumors. The present study was to explore the mechanism of hsa_circ_0087862 in regulating non-small cell lung cancer (NSCLC). Methods Totally 102 NSCLC cases were enrolled. NCI-H1359 and A549 cells were transfected. Cells viability, apoptosis, migration and invasion were dete...
Inhibition of miR-18a-3p reduces proliferation of mesothelioma cells and sensitizes them to cisplatin
Published in Oncology Letters
Malignant pleural mesothelioma is a notorious human malignancy. Despite combination chemotherapy with cisplatin and pemetrexed, the majority of patients with advanced malignant pleural mesothelioma have a poor prognosis. MicroRNAs (miRNAs/miRs) are short non-coding RNAs that regulate various biological processes by binding to the 3′-untranslated re...
miR-539 suppresses the proliferation, migration, invasion and epithelial mesenchymal transition of pancreatic cancer cel...
Published in International Journal of Molecular Medicine
MicroRNA (miR)-539 has inhibitory effects on certain types of cancer, but its role in pancreatic cancer (PCa) remains unclear. The present study investigated the effects of miR-539 on PCa, and aimed to determine possible therapeutic targets for the treatment of PCa. The expression of miR-539 in PCa tissues, paired normal adjacent tissues and PCa ce...
Decreased vitamin D receptor protein expression is associated with progression and poor prognosis of colorectal cancer p...
Published in International Journal of Clinical and Experimental Pathology
This study aimed to investigate vitamin D receptor (VDR) expression levels and evaluate their clinical significance in patients with colorectal cancer (CRC). VDR protein expression was validated by immunohistochemistry in 188 CRC tissues and 134 normal colorectal tissues. The associations between VDR expression and clinicopathologic characteristics...
GRIM-19 deficiency promotes clear cell renal cell carcinoma progression and is associated with high TNM stage and Fuhrma...
Published in Oncology Letters
Clear cell renal cell carcinoma (ccRCC) exhibits the highest mortality among all urological malignancies. The investigation of the potential disease progression markers can improve ccRCC diagnosis and treatment. Gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) is involved in carcinogenesis and cancer progression in a variety ...
