Jan van Weelden, Willem; Reijnen, Casper; Küsters-Vandevelde, Heidi VN; Bulten, Johan; Bult, Peter; Leung, Samuel; Visser, Nicole CM; Santacana, Maria; Bronsert, Peter; Hirschfeld, Marc;
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BACKGROUND: there is no consensus on the cut-off for positivity of estrogen receptor (ER) and progesterone receptor (PR) in endometrial cancer (EC). Therefore we determined the cut-off value for ER and PR with the strongest prognostic impact on outcome. METHODS: immunohistochemical expression of ER and PR was scored as a percentage of positive EC c...
Marquardt, Ryan M Lee, Kevin Kim, Tae Hoon Lee, Brandon DeMayo, Francesco J Jeong, Jae-Wook
Published in
Biology of reproduction
The endometrium, composed of epithelial and stromal cell compartments, is tightly regulated by the ovarian steroid hormones estrogen (E2) and progesterone (P4) during early pregnancy. Through the progesterone receptor (PGR), steroid receptor coactivators, and other transcriptional coregulators, progesterone inhibits E2-induced cell proliferation an...
Maiuri, Francesco Del Basso De Caro, Marialaura de Divitiis, Oreste Guadagno, Elia Mariniello, Giuseppe
Published in
British journal of neurosurgery
Objective: Spinal meningiomas are slow-growing tumors with low recurrence rate after complete resection. The aim of this study is to investigate the risk factors correlated to the recurrence.Material and Methods: Six patients with spinal WHO grade I meningiomas which recurred after complete resection were reviewed and compared to 50 patients with n...
Halari, C D Nandi, P Jeyarajah, M J Renaud, S J Lala, P K
Published in
Molecular human reproduction
Decidualization involves the proliferation and differentiation of fibroblast-like endometrial stromal cells into epithelioid-shaped and secretory 'decidual' cells in response to steroid hormones. Human decidual cells produce insulin-like growth factor-binding protein-1 and prolactin (PRL), two well-recognized markers of decidual cell maturation and...
Xi, Xun Huang, Xing-Wei Yuan, Huo-Zhong He, Chun Ni, Jun Yang, Fu-Lan
Published in
Oncology Letters
Whether the expression status of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2) receptor and Ki-67 show concordance between the primary tumors and the synchronous axillary lymph node (ALN) metastases has been discussed in numerous studies. However, to date, the results of these studies remain co...
Zeberg, Hugo Kelso, Janet Pääbo, Svante
Published in
Molecular biology and evolution
The hormone progesterone is important for preparing the uterine lining for egg implantation and for maintaining the early stages of pregnancy. The gene encoding the progesterone receptor (PGR) carries introgressed Neandertal haplotypes with two missense substitutions and a mobile Alu element. These Neandertal gene variants have reached nearly 20% f...
Pedroza, Diego A. Subramani, Ramadevi Lakshmanaswamy, Rajkumar
Published in
Cancers
Much emphasis is placed on estrogen (E2) and estrogen receptor (ER) signaling as most research is focused on understanding E2 and ER’s ability to enhance proliferative signals in breast cancers. Progesterone (P4) is important for normal mammary gland development, function and menstrual control. However, P4 and its receptors (PRs) in breast cancer e...
Kunc, Michał Popęda, Marta Szałkowska, Anna Niemira, Magdalena Bieńkowski, Michał Pęksa, Rafał Łacko, Aleksandra Radecka, Barbara S. Braun, Marcin Pikiel, Joanna
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Published in
Diagnostics
Estrogen (ER) and progesterone (PgR) receptors and HER2 are crucial in the assessment of breast cancer specimens due to their prognostic and predictive significance. Single hormone receptor-positive breast cancers are less common and their clinical course is less favorable than ER(+)/PgR(+) tumors. Their molecular features, especially microRNA (miR...
Sohail, Shahzada K Sarfraz, Rahat Imran, Muhammad Kamran, Muhammad Qamar, Samina
Published in
Cureus
Introduction The prognosis of breast cancer depends on the histological type, size of the tumor, tumor necrosis, skin, nipple and chest wall invasion, lymphovascular invasion, grade, stage, the status of estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2), cell proliferation marker (ki-67), and t...
Ide, Hiroki Miyamoto, Hiroshi
Published in
Cancers
Preclinical and/or clinical evidence has indicated a potential role of steroid hormone-mediated signaling pathways in the development of various neoplastic diseases, while precise mechanisms for the functions of specific receptors remain poorly understood. Specifically, in urothelial cancer where sex-related differences particularly in its incidenc...