Couloume, Laura Barbin, Laetitia Leray, Emmanuelle Wiertlewski, Sandrine Le Page, Emmanuelle Kerbrat, Anne Ory, Solenn Le Port, Damien Edan, Gilles Laplaud, David-Axel
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
A recent controlled trial suggested that high-dose biotin supplementation reverses disability progression in patients with progressive multiple sclerosis. To analyze the impact of high-dose biotin in routine clinical practice on disability progression at 12 months. Progressive multiple sclerosis patients who started high-dose biotin at Nantes or Re...
Kozin, M. S. Kulakova, O. G. Kiselev, I. S. Boyko, A. N. Favorova, O. O.
Published in
Molecular Biology
AbstractsRecently, it has been shown that dysfunction of mitochondria is an important component of the molecular mechanisms of the development of many neurodegenerative diseases. These include multiple sclerosis, a chronic autoimmune and neurodegenerative disease of the central nervous system, which is characterized by clinical heterogeneity. The r...
Wolinsky, Jerry S Engmann, Natalie J Pei, Jinglan Pradhan, Ashish Markowitz, Clyde Fox, Edward J
Published in
Multiple Sclerosis Journal - Experimental, Translational and Clinical
Background Ocrelizumab, an anti-CD20 humanized monoclonal antibody, reduced disease progression in pivotal trials of patients with relapsing (OPERA I, OPERA II) and primary progressive (ORATORIO) multiple sclerosis (MS). These effects may be particularly important among patients with increased disability. Objective In this post hoc exploratory anal...
Engel, Sinah Luessi, Felix Mueller, Aneka Schopf, Rudolf E Zipp, Frauke Bittner, Stefan
Published in
Therapeutic advances in neurological disorders
Since their introduction in 1999, anti-tumour necrosis factor-α (anti-TNF-α) therapies have been suspected repeatedly to be associated with the occurrence of central nervous system (CNS) demyelinating disorders, including multiple sclerosis (MS). However, recent publications were restricted to descriptions of monophasic demyelinating events or case...
Kiselev, I. S. Kulakova, O. G. Baulina, N. M. Bashinskaya, V. V. Popova, E. V. Boyko, A. N. Favorova, O. O.
Published in
Molecular Biology
AbstractMultiple sclerosis is a chronic disease of the central nervous system, combining in its pathogenesis both autoimmune and neurodegenerative components, and is characterized by a highly heterogeneous clinical phenotype. Genetic susceptibility to the development of the most common relapsing-remitting course of the disease is extensively studie...
Bigaut, Kévin De Seze, Jérôme Collongues, Nicolas
Published in
Expert review of neurotherapeutics
In the past decade, the role of B cells in the pathogenesis of multiple sclerosis (MS) is coming to the forefront. Depletion of B cells by anti-CD20 monoclonal antibodies (mAbs) has proved to decrease the activity of the relapsing-remitting MS (RRMS) and the progression of primary progressive MS (PPMS). Areas covered: In this review, the authors di...
Pawlitzki, Marc Schreiber, Stefanie Bittner, Daniel Kreipe, Julia Leypoldt, Frank Rupprecht, Klemens Carare, Roxana O. Meuth, Sven G. Vielhaber, Stefan Körtvélyessy, Peter
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Published in
Frontiers in Neurology
Objectives: Elevated neurofilament light chain (NFL) levels within the cerebrospinal fluid (CSF) are a biomarker representing axonal neurodegeneration in rapid progressive neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). It is unclear to what extent the levels of NFL increase in the CSF (CSF-NFL) in a chronic neuroinflammator...
Vistbakka, J Sumelahti, M-L Lehtimäki, T Elovaara, I Hagman, S
Published in
Acta neurologica Scandinavica
Biomarkers that could be used in early diagnosis of multiple sclerosis (MS), segregation of disease subtypes, and discrimination of the aggressive disease course from the benign one are urgently needed. The aim of this study was to investigate the specificity of circulating microRNAs: miR-191-5p, miR-128-3p, miR-24-3p, and miR-376c-3p in MS and eva...
Popova, E. V. Kiselev, I. S. Boiko, A. N. Sivertseva, S. A. Malkova, N. A. Korobko, D. S. Spirin, N. N. Kasatkin, D. S. Karaeva, A. V. Turova, E. L.
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Published in
Neuroscience and Behavioral Physiology
Objectives. To analyze the involvement of immune response genes in the pathogenesis of primary progressive multiple sclerosis (PPMS). Materials and methods. A representative cohort of 111 ethnically Russian patients with PPMS took part in a multicenter study. The involvement of immune system genes in the pathogenesis of PPMS was analyzed by investi...
Bryukhov, V. V. Krotenkova, I. A. Morozova, S. N. Krotenkova, M. V.
Published in
Neuroscience and Behavioral Physiology
MRI scanning is the main widely used diagnostic method for multiple sclerosis (MS). This article discusses the current state of the question of the effectiveness of using brain and spinal cord MRI scans in the diagnosis of patients with suspected MS. Particular attention is paid to the McDonald MRI and MAGNIMS criteria as revised in 2010 and 2016 f...
