Mo, Shao-jian Zhao, Hai-Chao Tian, Yan-zhang Zhao, Hao-Liang
Published in
Cancer Management and Research
Prefoldin (PFDN) is a hexameric chaperone complex that is widely found in eukaryotes and archaea and consists of six different subunits (PFDN1-6). Its main function is to transfer actin and tubulin monomers to the eukaryotic cell cytoplasmic chaperone protein (c-CPN) specific binding during the assembly of the cytoskeleton, to stabilize the newly s...
Peñate, Xenia Praena-Fernández, Juan Manuel Romero Pareja, Pedro Enguix-Riego, María del Valle Payán-Bravo, Laura Vieites, Begoña Gomez-Izquierdo, Lourdes Jaen Olasolo, Javier Rivin del Campo, Eleonor Reyes, Jose Carlos
...
Published in
Cancers
Canonical prefoldin is a protein cochaperone composed of six different subunits (PFDN1 to 6). PFDN1 overexpression promotes epithelial–mesenchymal transition (EMT) and increases the growth of xenograft lung cancer (LC) cell lines. We investigated whether this putative involvement of canonical PFDN in LC translates into the clinic. First, the mRNA e...
Zhang, Jin Xie, Meng Li, Mi Ding, Jinhua Pu, Yunqiao Bryan, Anthony C Rottmann, William Winkeler, Kimberly A Collins, Cassandra M Singan, Vasanth
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Prefoldin (PFD) is a group II chaperonin that is ubiquitously present in the eukaryotic kingdom. Six subunits (PFD1-6) form a jellyfish-like heterohexameric PFD complex and function in protein folding and cytoskeleton organization. However, little is known about its function in plant cell wall-related processes. Here, we report the functional chara...
Televantos, Constantinos
This thesis describes a large-scale forward genetic screen in zebrafish for host determinants of mycobacterial infection outcome that I participated in. Zebrafish larvae from families randomly mutagenized with N-ethyl-N-nitrosourea were infected with Mycobacterium marinum and monitored over time. Larvae with increased susceptibility to infection we...
Zhang, Jin Xie, Meng Li, Mi Ding, Jinhua Pu, Yunqiao Bryan, Anthony C. Rottmann, William Winkeler, Kimberly A. Collins, Cassandra M. Singan, Vasanth
...
Published in
Plant Biotechnology Journal
Prefoldin (PFD) is a group II chaperonin that is ubiquitously present in the eukaryotic kingdom. Six subunits (PFD1‐6) form a jellyfish‐like heterohexameric PFD complex and function in protein folding and cytoskeleton organization. However, little is known about its function in plant cell wall‐related processes. Here, we report the functional chara...
Lim, Samuel Jung, Gi Ahn Glover, Dominic J Clark, Douglas S
Published in
Small (Weinheim an der Bergstrasse, Germany)
Precisely organized enzyme complexes are often found in nature to support complex metabolic reactions in a highly efficient and specific manner. Scaffolding enzymes on artificial materials has thus gained attention as a promising biomimetic strategy to design biocatalytic systems with enhanced productivity. Herein, a versatile scaffolding platform ...
Gestaut, Daniel Roh, Soung Hun Ma, Boxue Pintilie, Grigore Joachimiak, Lukasz A Leitner, Alexander Walzthoeni, Thomas Aebersold, Ruedi Chiu, Wah Frydman, Judith
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Published in
Cell
Maintaining proteostasis in eukaryotic protein folding involves cooperation of distinct chaperone systems. To understand how the essential ring-shaped chaperonin TRiC/CCT cooperates with the chaperone prefoldin/GIMc (PFD), we integrate cryoelectron microscopy (cryo-EM), crosslinking-mass-spectrometry and biochemical and cellular approaches to eluci...
Lim, Samuel
Self-assembling protein templates are of increasing interest in the field of nanoscale fabrication of biomaterials, where precise patterning of functional biomolecules, such as enzymes, is often desired. In particular, protein building blocks can be strategically chosen to exhibit desired functionality, while engineering their assembly allows for t...
Houry, Walid A Bertrand, Edouard Coulombe, Benoit
Published in
Trends in biochemical sciences
The Rvb1-Rvb2-Tah1-Pih1/prefoldin-like (R2TP/PFDL) complex is a unique chaperone that provides a platform for the assembly and maturation of many key multiprotein complexes in mammalian cells. Here, we propose to rename R2TP/PFDL as PAQosome (particle for arrangement of quaternary structure) to more accurately represent its unique function. Copyrig...
Lipinski, Kamil Andrzej Britschgi, Christian Schrader, Karen Christinat, Yann Frischknecht, Lukas Krek, Wilhelm
Published in
Oncotarget
Chaperone dependency of cancer cells is an emerging trait that relates to the need of transformed cells to cope with the various stresses associated with the malignant state. URI1 (unconventional prefoldin RPB5 interactor 1) encodes a member of the prefoldin (PFD) family of molecular chaperones that acts as part of a heterohexameric PFD complex, th...