Yang, Yuhan Sun, Ziyi Sun, Xiaoning Zhang, Jin Tong, Tong Zhang, Xiaoxiao Yao, Kuiwu
Published in
Frontiers in Pharmacology
Background Salvianolic acid B is the most abundant water-soluble component in the traditional Chinese medicine Danshen and can reduce myocardial ischemia-reperfusion (MI/R) injury through multiple targets and pathways. However, the role of SalB in protecting the myocardium from ischemia/reperfusion injury remains unclear. Purpose To perform a precl...
Nekhaeva, T L Laskov, I D Fedoros, E I Danilova, A B Yurova, M N Tyndyk, M L Ermakova, E D Emelyanova, N V Efremova, N A Grigorevskaya, A V
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Published in
Bulletin of experimental biology and medicine
Homologous animal cell product was obtained in protocol developed for female BALB/c mice. Dendritic cell (DC) migration from the injection site into the draining lymph nodes was evaluated. The number of DC labeled with carboxyfluorescein succinimidyl ester (CFSE) in draining lymph nodes increased from 5.3% (16 h) to 13.3% (48 h) (p=0.028) with a ma...
Sharma, Aditya Kumar Giri, Anil K.
Published in
Frontiers in Genetics
The discovery of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) technology has revolutionized field of cancer treatment. This review explores usage of CRISPR/Cas9 for editing and investigating genes involved in human carcinogenesis. It provides insights into the development of CRISPR as a g...
Zheng, Min Kumar, Ankush Sharma, Vishakha Behl, Tapan Sehgal, Aayush Wal, Pranay Shinde, Nirmala Vikram Kawaduji, Bhosale Sachin Kapoor, Anupriya Anwer, Md. Khalid
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Published in
Frontiers in Cell and Developmental Biology
Neuroblastoma (NB) is the most frequent solid tumor in pediatric cases, contributing to around 15% of childhood cancer-related deaths. The wide-ranging genetic, morphological, and clinical diversity within NB complicates the success of current treatment methods. Acquiring an in-depth understanding of genetic alterations implicated in the developmen...
Kong, Youqian Wang, Xiaoyu Qie, Rui
Published in
Frontiers in Oncology
Immune checkpoint inhibitors (ICIs) have become a widely accepted and effective treatment for various types of solid tumors. Recent studies suggest that cardiovascular immune-related adverse events (irAEs) specifically have an incidence rate ranging from 1.14% to more than 5%. Myocarditis is the most common observed cardiovascular irAE. Others incl...
Nyayapathi, Nikhila Zheng, Emily Zhou, Qifa Doyley, Marvin Xia, Jun
Published in
Frontiers in Photonics
Photoacoustic imaging is a novel biomedical imaging modality that has emerged over the recent decades. Due to the conversion of optical energy into the acoustic wave, photoacoustic imaging offers high-resolution imaging in depth beyond the optical diffusion limit. Photoacoustic imaging is frequently used in conjunction with ultrasound as a hybrid m...
Norman, Trevor R.
Published in
Exploration of Medicine
Schizophrenia is a serious mental disorder affecting about 1% of the population. It is characterised by multiple symptoms which are mostly responsive to treatment with antipsychotic medications. Cognitive impairment is regarded as a core feature of illness which is mostly poorly responsive to treatment with the current antipsychotic medications. Im...
Wu, Yang Li, Tianli Li, Pochen Peng, HsuanChieh Gao, Ang Wang, Jisheng Zhu, Haiyan Wang, Xian
Published in
Frontiers in Pharmacology
Objective: This study aims to evaluate the clinical and preclinical efficacy of SMI in treating CHF, and to summarize the relevant mechanisms of action in order to provide evidence for its role in CHF treatment. Methods: A systematic computerized search of eight databases and three registry systems was performed, with the time frame spanning from t...
Liu, Boxin Zhang, Jinyu Zhou, Zijing Feng, Baofeng He, Jingjing Yan, Wei Zhou, Xinghong Amponsah, Asiamah Ernest Guo, Ruiyun Du, Xiaofeng
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Published in
Current stem cell research & therapy
Diabetic cardiomyopathy (DCM) is a complication of diabetes mellitus that endangers human health. DCM results in cardiac dysfunction, which eventually progresses to heart failure. Mesenchymal stromal cells (MSCs), a type of multipotent stem cell, have shown promising therapeutic effects in various cardiovascular diseases and diabetic complications ...
Park, Seung Hyun Park, Seoyeon Hong, Sung Hwi Lee, Se Bee Kim, Eun Young Pizzol, Damiano Trott, Mike Smith, Lee Barnett, Yvonne Koyanagi, Ai
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Objective: To investigate the prevalence and trends of essential study design elements in preclinical urological studies, as well as key factors that may improve methodological rigour, as the demand for methodological rigour in preclinical studies is increasing since research reproducibility and transparency in the medico-scientific field are being...
