Song, Ke Liang, Dianyuan Xiao, Dingqi Kang, Aijia Ren, Yixing
Published in
Molecular medicine reports
Diabetic cardiomyopathy (DCM), a significant complication of diabetes mellitus, is marked by myocardial structural and functional alterations due to chronic hyperglycemia. Despite its clinical significance, optimal treatment strategies are still elusive. Bariatric surgery via sleeve gastrectomy and Roux-en-Y gastric bypass have shown promise in tre...
Naja, Khaled Anwardeen, Najeha Bashraheel, Sara S. Elrayess, Mohamed A.
Published in
Journal of Pharmacy & Pharmaceutical Sciences
Background Sulfonylureas have been a longstanding pharmacotherapy in the management of type 2 diabetes, with potential benefits beyond glycemic control. Although sulfonylureas are effective, interindividual variability exists in drug response. Pharmacometabolomics is a potent method for elucidating variations in individual drug response. Identifyin...
Xie, Yiluo Chen, Huili Tian, Mei Wang, Ziqang Wang, Luyao Zhang, Jing Wang, Xiaojing Lian, Chaoqun
Published in
Frontiers in Immunology
Introduction The programmed cell death (PCD) plays a key role in the development and progression of lung adenocarcinoma. In addition, immune-related genes also play a crucial role in cancer progression and patient prognosis. However, further studies are needed to investigate the prognostic significance of the interaction between immune-related gene...
Yazarlou, Fatemeh Martinez, Ivan Lipovich, Leonard
Published in
Frontiers in Oncology
Radiotherapy (RT) serves as one of the key adjuvant treatments in management of breast cancer. Nevertheless, RT has two major problems: side effects and radioresistance. Given that patients respond differently to RT, it is imperative to understand the molecular mechanisms underlying these differences. Two-thirds of human genes do not encode protein...
Zhang, Xin Su, Rui Wang, Hui Wu, Ruihe Fan, Yuxin Bin, Zexuan Gao, Chong Wang, Caihong
Published in
Frontiers in Immunology
Rheumatoid arthritis (RA) affects millions of people worldwide, but there are limited drugs available to treat it, so acquiring a more comprehensive comprehension of the underlying reasons and mechanisms behind inflammation is crucial, as well as developing novel therapeutic approaches to manage it and mitigate or forestall associated harm. It is e...
Xia, Mengying Varmazyad, Mahboubeh Pla-Palacín, Iris Gavlock, Dillon C. DeBiasio, Richard LaRocca, Gregory Reese, Celeste Florentino, Rodrigo M. Faccioli, Lanuza A. P. Brown, Jacquelyn A.
...
Published in
Frontiers in Cell and Developmental Biology
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a worldwide health epidemic with a global occurrence of approximately 30%. The pathogenesis of MASLD is a complex, multisystem disorder driven by multiple factors, including genetics, lifestyle, and the environment. Patient heterogeneity presents challenges in developing MASLD ther...
Fraunhoffer, Nicolas Teyssedou, Carlos Pessaux, Patrick Bigonnet, Martin Dusetti, Nelson Iovanna, Juan
Published in
Frontiers in Oncology
Background The utilization of modified FOLFIRINOX (mFFX) therapy has shown notable advancements in patient outcomes in both localized and metastatic PDAC. Nevertheless, the effectiveness of mFFX treatment comes at the cost of elevated toxicity, leading to its restriction to patients with adequate performance status. Consequently, the administration...
Tommasi, Stefania Maurmo, Leonarda Rizzo, Alessandro Carella, Claudia Ranieri, Girolamo De Summa, Simona Mannavola, Francesco Chiurì, Vincenzo Emanuele Guida, Michele Nisi, Claudia
...
Published in
Frontiers in Medicine
Introduction The management of cancer patients follows a Diagnostic Therapeutic and Care Pathway (PDTA) approach, aimed at achieving the optimal balance between care and quality of life. To support this process, precision medicine and innovative technologies [e.g., next-generation sequencing (NGS)] allow rapid identification of genetic-molecular al...
Le Ngoc, Khanh Pham, Tran Thu Ha Nguyen, Tiep Khac Huong, Phung Thanh
Published in
Frontiers in Immunology
The burgeoning field of pharmacomicrobiomics offers promising insights into the intricate interplay between the microbiome and cancer, shaping responses to diverse treatment modalities. This review aims to analyze the molecular mechanisms underlying interactions between distinct microbiota types and cancer, as well as their influence on treatment o...
Connell, Emily Gerard, Émilie Oules, Bénédicte Brunet-Possenti, Florence Lamoureux, Anouck Bonnefille, Hugo Mary-Prey, Sorilla Carrasquilla, Ana Mouret, Stéphane Kramkimel, Nora
...
Published in
The oncologist
Only a fraction of patients with metastatic melanoma derive durable benefit from approved treatments. The clinical impact of personalized medicine strategies for melanoma, apart from BRAF, NRAS, or CKIT targeting, has rarely been reported. By means of the Group of Cutaneous Oncology of the French Society of Dermatology, we retrospectively included ...
