Published in Metabolites
Environmental exposures such as nutrition during life stages with high developmental plasticity—in particular, the in utero period, infancy, childhood, and puberty—may have long-lasting influences on risk of chronic diseases, including obesity-related conditions that manifest as early as childhood. Yet, specific mechanisms underlying these relation...
Published in Frontiers in Cellular and Infection Microbiology
Chagas disease, caused by the infection with the protozoan parasite Trypanosoma cruzi , is clinically manifested in approximately one-third of infected people by inflammatory heart disease (cardiomyopathy) and, to a minor degree, gastrointestinal tract disorders (megaesophagus or megacolon). Chagas disease is a zoonosis transmitted among animals an...
Published in Journal of Medical Internet Research
Background Several studies have shown that facial attention differs in children with autism. Measuring eye gaze and emotion recognition in children with autism is challenging, as standard clinical assessments must be delivered in clinical settings by a trained clinician. Wearable technologies may be able to bring eye gaze and emotion recognition in...
Published in Journal of Medical Internet Research
This viewpoint describes the urgent need for more large-scale, deep digital phenotyping to advance toward precision health. It describes why and how to combine real-world digital data with clinical data and omics features to identify someone’s digital twin, and how to finally enter the era of patient-centered care and modify the way we view disease...
Published in Journal of Personalized Medicine
Treating disease according to precision health requires the individualization of therapeutic solutions as a cardinal step that is part of a process that typically depends on multiple factors. The starting point is the collection and assembly of data over time to assess the patient’s health status and monitor response to therapy. Radiomics is a very...
Published in Journal of public health dentistry
The information in this article is based on a presentation given at the American Institute of Dental Public Health's 2018 Colloquium on Precision Public Health (PPH). A brief introduction to precision medicine provides context for PPH. Precision medicine tailors treatment and prevention strategies for individual patients based on variability of gen...
Published in Journal of Clinical Medicine
During the Dutch winter famine of 1944–1945, an interesting observation was made about the offspring born during this time—They had an increased risk of developing metabolic syndrome and other chronic diseases. Subsequent research has confirmed this finding as well as noting that health outcomes for many diseases are different, and often worse, for...
Massively parallel sequencing is emerging from research settings into clinical practice, helping the vision of precision medicine to become a reality. The most successful applications are using the tools of implementation science within the framework of the learning health-care system. This article examines the application of massively parallel seq...
Published in Personalized medicine
A bibliometric analysis was conducted to describe trends in the publication of precision medicine literature over time. Searches identified 5552 articles with exponential growth from 2012 to 2018. Most were published in medical specialty journals, particularly oncology. Precision medicine definitions focused on tailored/individualized/personalized ...
Published in Advances in geriatric medicine and research
Efforts to provide patients with individualized treatments have led to tremendous breakthroughs in healthcare. However, a precision medicine approach alone will not offset the rapid increase in prevalence and burden of chronic non-communicable illnesses that is continuing to pervade the world’s aging population. With rapid advances in technology, i...
