Photodermatology, photoimmunology & photomedicine
In our large hospital series, the appearance of PCT among HIV-infected patients is low (
Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Porphyrias are diverse disorders that arise from various inherited enzyme defects in the heme biosynthesis pathway, except for porphyria cutanea tarda (PCT), in which the enzyme deficiency in most cases is acquired. The biosynthetic blocks resulting from the defective enzymes are largely expressed either in the liver or bone marrow, the sites where...
A porfiria cutânea tarda resulta de uma deficiência enzimática na biossíntese do heme, manifesta-se por alterações cutâneas e está associada a disfunção hepática, podendo ser desencadeada por sobrecarga de ferro. Os autores apresentam o caso de uma doente de 40 anos com porfiria cutânea tarda associada a hemocromatose.
We describe here the development, validation, quantification and application of a method for determination of heme porphyrin precursors in the urine of porphyric patients. The isomers coproporphyrinogen I and III (COPRO I and III), uroporphyrinogen I (URO I), heptacarboxylporphyrinogen I (HEPTA I), pentacarboxylporphyrinogen (PENTA I), and hexacarb...
Porphyria cutanea tarda (PCT) can occur in HIV patients. Current evidence suggests that HIV infection may interfere with the hepatic cytochrome oxidase system, leading to porphyrin metabolism impairment. Moreover, chronic hemodialysis in renal failure may be a risk factor for PCT. In addition to the contributory factors for PCT associated to HIV in...
Indian journal of sexually transmitted diseases
A 30-year-old unmarried, heterosexual male presented with an 8-month history of tense blistering skin lesions over the hands. Physical examination revealed facial hypertrichosis and multiple erosions with crusts and scars over the dorsum of both hands. Woods lamp examination of the urine, histopathology and urinary porphyrin levels were suggestive ...
The porphyrias are a group of mainly inherited disorders of heme biosynthesis where accumulation of porphyrins and/or porphyrin precursors gives rise to two types of clinical presentation: cutaneous photosensitivity and/or acute neurovisceral attacks. The cutaneous porphyrias present with either bullous skin fragility (porphyria cutanea tarda, vari...
Encyclopedia of Microbiology
Hemes are involved in many cellular processes in prokaryotes and eukaryotes. Whereas the classic role for heme is in respiration and oxygen metabolism, it is now known to play important roles in perception and signaling. The biosynthetic pathway leading to heme formation is, with a few interesting exceptions, well conserved and is controlled in acc...
This study focuses on the alterations suffered by the serotoninergic and kinurenergic routes of tryptophan (TRP) metabolism in liver, and their relation with gluconeogenic phosphoenolpyruvate-carboxykinase (PEPCK) blockage in experimental acute porphyria. This porphyria was induced in rats by a combined treatment of 2-allyl-2-isopropylacetamide (10...