Miyasaka, Yuhei Komatsu, Shuichiro Abe, Takanori Kubo, Nobuteru Okano, Naoko Shibuya, Kei Shirai, Katsuyuki Kawamura, Hidemasa Saitoh, Jun-Ichi Ebara, Takeshi
...
Published in
Cancers
Lung cancer is a leading cause of cancer-related deaths worldwide. Radiotherapy is an essential treatment modality for inoperable non-small cell lung cancer (NSCLC). Stereotactic body radiotherapy (SBRT) is the standard treatment for early-stage NSCLC because of its favorable local control (LC) compared to conventional radiotherapy. Carbon ion radi...
Sandler, Melissa Hoang, Cuong Mak, Hannah Y Levitt, Michael R
Published in
Journal of neurointerventional surgery
Antiplatelet therapy is used to prevent stent thrombosis in intracranial stents, but the optimal dose of aspirin is unknown. This study sought to determine whether the degree of platelet inhibition with aspirin is affected by bodyweight as observed through a platelet reactivity assay. This is a retrospective review of patients who underwent neurova...
DeRoo, Elise; Martinod, Kimberly; 110894; Cherpokova, Deya; Fuchs, Tobias; Cifuni, Stephen; Chu, Long; Staudinger, Caleb; Wagner, Denisa D;
PURPOSE: Platelets are known to play an important role in venous thrombogenesis, but their role in thrombus maturation, resolution, and postthrombotic vein wall remodeling is unclear. The purpose of this study was to determine the role that circulating platelets play in the later phases of venous thrombosis. METHODS: We used a murine inferior vena ...
Vecchio, Michele Chiaramonte, Rita Romano, Marcello Pavone, Piero Musumeci, Giuseppe Mauro, Giulia Letizia
Published in
Diagnostics (Basel, Switzerland)
The aim of this systematic review is to guide the physician in defining the pharmacologic and rehabilitative therapeutic approaches for adopting the best strategies described in the current literature. The search was conducted in PubMed, EMBASE, Cochrane Library and Web of Science to identify the treatment of small fiber neuropathies. Two reviewers...
Braune, Steffen Küpper, Jan-Heiner Jung, Friedrich
Published in
International journal of molecular sciences
Prostanoids are bioactive lipid mediators and take part in many physiological and pathophysiological processes in practically every organ, tissue and cell, including the vascular, renal, gastrointestinal and reproductive systems. In this review, we focus on their influence on platelets, which are key elements in thrombosis and hemostasis. The funct...
Folimonova, Svetlana Y Achor, Diann Bar-Joseph, Moshe
Published in
Viruses
"Cross-protection", a nearly 100 years-old virological term, is suggested to be changed to "close protection". Evidence for the need of such change has accumulated over the past six decades from the laboratory experiments and field tests conducted by plant pathologists and plant virologists working with different plant viruses, and, in particular, ...
Ortega-Paz, Luis Capodanno, Davide Montalescot, Gilles Angiolillo, Dominick J
Published in
Journal of the American Heart Association
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which has posed a significant threat to global health. Although the infection is frequently asymptomatic or associated with mild symptoms, in a small proportion of patients it can produce an intense inflammatory and pr...
De Kock, Lore Freson, Kathleen
Published in
Medicina (Kaunas, Lithuania)
Proto-oncogene tyrosine-protein kinase SRC (SRC), as other members of the SRC family kinases (SFK), plays an important role in regulating signal transduction by different cell surface receptors after changes in the cellular environment. Here, we reviewed the role of SRC in platelets and megakaryocytes (MK). In platelets, inactive closed SRC is coup...
Izzi, Benedetta; Tirozzi, Alfonsina; Cerletti, Chiara; Donati, Maria Benedetta; de Gaetano, Giovanni; Hoylaerts, Marc F; 12701; Iacoviello, Licia; Gialluisi, Alessandro;
Alongside their function in primary haemostasis and thrombo-inflammation, platelets are increasingly considered a bridge between mental, immunological and coagulation-related disorders. This review focuses on the link between platelets and the pathophysiology of major depressive disorder (MDD) and its most frequent comorbidities. Platelet- and neur...
Rogula, Sylwester P Mutwil, Hubert M Gąsecka, Aleksandra Kurzyna, Marcin Filipiak, Krzysztof J
Published in
Cardiology journal
Prostacyclin and analogues are successfully used in the treatment of pulmonary arterial hypertension (PAH) due to their vasodilatory effect on pulmonary arteries. Besides vasodilatory effect, prostacyclin analogues inhibit platelets, but their antiplatelet effect is not thoroughly established. The antiplatelet effect of prostacyclin analogues may b...
