Conventionally, a first-in-human phase I trial in healthy volunteers aims to confirm the safety of a drug in humans. In such situations, volunteers should not suffer from any safety issues and simple algorithm-based dose-escalation schemes are often used. However, to avoid too many clinical trials in the future, it might be appealing to design thes...
Published in Frontiers in Cellular Neuroscience
For animals to meet environmental challenges, the activity patterns of specialized oscillatory neural circuits, central pattern generators (CPGs), controlling rhythmic movements like breathing and locomotion, are adjusted by neuromodulation. As a representative example, the leech heartbeat is controlled by a CPG driven by two pairs of mutually inhi...
Published in Frontiers in Public Health
Objective To investigate the short-term changes in chest CT images of low-altitude populations after entering a high-altitude environment. Methods Chest CT images of 3,587 people from low-altitude areas were obtained within one month of entering a high-altitude environment. Abnormal CT features and clinical symptoms were analyzed. Results Besides a...
Background: The aim of this study was to compare the impact of three different types of intraoperative antibiotic prophylaxis on the risk of postoperative surgical site infection (SSI). Material and Methods: Single-center retrospective cohort study. Patients who underwent surgery for osteosynthesis of a tibial plateau fracture (January 2009–Novembe...
Published in Journal of Physics D: Applied Physics
Elastocaloric effect (eCE) is a very promising candidate for using in non-vapor compression refrigeration, which is highly efficient and eco-friendly. However, designing elastocaloric alloys with a wide reversible working temperature window at low stress is still challenging. In this work, the transition behaviors, microstructural evolutions and th...
Global climate change has significantly impacted waterbird communities in the warming and humidifying wetlands of the Qinghai–Tibet Plateau. However, further research is needed as these wetlands transition to warmer and drier states. This study focused on the diversity and richness of wintering birds in the alpine wetlands of the Yamzho Yumco Lake....
Published in Folia Forestalia Polonica
In this study, analysis of sales, costs and demands for timber species was carried out in selected timber markets of Plateau State, Nigeria. Association as well as relationship between factors influencing timber sales, costs and demands were investigated, and the dependency of timber sales on factors affecting it was ascertained. Data obtained thro...
Run time analysis of evolutionary algorithms recently makes significant progress in linking algorithm performance to algorithm parameters. However, settings that study the impact of problem parameters are rare. The recently proposed W-model provides a good framework for such analyses, generating pseudo-Boolean optimization problems with tunable pro...
(1) Background: Bangor Sewa sheep are an economically significant livestock species on the plateau. The roles of microbiota in reproduction are complex and critical for animal health. But little is known currently about the microbiome of plateau Bangor Sewa sheep. The purpose of this study was to discover the changes in the genital tract microbiota...
The purpose of this retrospective case series was to review the demographics of alpine skiers who sustain tibial plateau fractures, evaluate the inter-observer reliability of the Schatzker classification for fractures sustained while alpine skiing, and to evaluate patient-reported outcomes. We hypothesized that most tibial plateau fractures would b...
