hussain, shafaat jha, sandeep berger, evelin molander, linnea sevastianova, valentyna sheybani, zahra espinosa, aaron shekka elmahdy, ahmed al-awar, amin kakaei, yalda
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Background: ST-elevation myocardial infarction (STEMI) and Takotsubo syndrome (TS) are two distinct cardiac conditions that both result in sudden loss of cardiac dysfunction and that are difficult to distinguish clinically. This study compared plasma protein changes in 24 women with STEMI and 12 women with TS in the acute phase (days 0–3 post sympt...
Deng, Sui Mao, Rui He, Yifeng
Published in
Frontiers in Immunology
Background The current landscape of acne therapeutics is notably lacking in targeted treatments, highlighting a critical need for the discovery of new drug targets to improve treatment outcomes. Objectives This study aims to investigate the connections between proteomics and genetics in relation to acne across extensive population cohorts, aspiring...
mcdowell, colin t. weaver, amanda l. vargas-cruz, nylev kaiser, nathan k. nichols, charles m. pestano, gary a.
Background: There is significant interest in developing alternatives to traditional blood transportation and separation methods, which often require centrifugation and cold storage to preserve specimen integrity. Here we provide new performance findings that characterize a novel device that separates whole blood via lateral flow then dries the isol...
Chen, Ming-Li Kho, Pik Fang Guarischi-Sousa, Rodrigo Zhou, Jiayan Panyard, Daniel J. Azizi, Zahra Gupte, Trisha Watson, Kathleen Abbasi, Fahim Assimes, Themistocles L.
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Published in
Frontiers in Cardiovascular Medicine
Background and aims Ultrasound derived carotid intima-media thickness (cIMT) is valuable for cardiovascular risk stratification. We assessed the relative importance of traditional atherosclerosis risk factors and plasma proteins in predicting cIMT measured nearly a decade later.Method We examined 6,136 UK Biobank participants with 1,461 proteins pr...
núñez, estefanía gómez-serrano, maría calvo, enrique bonzon-kulichenko, elena trevisan-herraz, marco rodríguez, josé manuel garcía-marqués, fernando magni, ricardo lara-pezzi, enrique martín-ventura, josé luis
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Despite the plasma proteome being able to provide a unique insight into the health and disease status of individuals, holding singular promise as a source of protein biomarkers that could be pivotal in the context of personalized medicine, only around 100 proteins covering a few human conditions have been approved as biomarkers by the US Food and D...
Křenek, Pavel Bartečková, Eliška Makarová, Markéta Pompa, Tomáš Fialová Kučerová, Jana Kučera, Jan Damborská, Alena Hořínková, Jana Bienertová-Vašků, Julie
Published in
Frontiers in Psychiatry
Objectives This study aimed to explore the relationship between plasma proteome and the clinical features of Major Depressive Disorder (MDD) during treatment of acute episode. Methods In this longitudinal observational study, 26 patients hospitalized for moderate to severe MDD were analyzed. The study utilized Liquid Chromatography with Tandem Mass...
lange, simon tsohataridis, simeon boland, niklas ngo, lisa hahad, omar münzel, thomas wild, philipp daiber, andreas schuppan, detlef lurz, philipp
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Introduction: The exposome concept includes nutrition as it significantly influences human health, impacting the onset and progression of diseases. Gluten-containing wheat products are an essential source of energy for the world’s population. However, a rising number of non-celiac healthy individuals tend to reduce or completely avoid gluten-contai...
Yang, Ni Shi, Liangyuan Xu, Pengfei Ren, Fang Lv, Shimeng Li, Chunlin Qi, Xianghua
Published in
Frontiers in Neurology
Introduction Insomnia, a common clinical disorder, significantly impacts the physical and mental well-being of patients. Currently, available hypnotic medications are unsatisfactory due to adverse reactions and dependency, necessitating the identification of new drug targets for the treatment of insomnia. Methods In this study, we utilized 734 plas...
urbiola-salvador, víctor de souza, suiane lima macur, katarzyna czaplewska, paulina chen, zhi
Despite great scientific efforts, deep understanding of coronavirus-19 disease (COVID-19) immunopathology and clinical biomarkers remains a challenge. Pre-existing comorbidities increase the mortality rate and aggravate the exacerbated immune response against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, which can resu...
Doulidis, Pavlos G. Kuropka, Benno Frizzo Ramos, Carolina Rodríguez-Rojas, Alexandro Burgener, Iwan A.
Published in
Frontiers in Veterinary Science
Introduction Bloodwork is a widely used diagnostic tool in veterinary medicine, as diagnosis and therapeutic interventions often rely on blood biomarkers. However, biomarkers available in veterinary medicine often lack sensitivity or specificity. Mass spectrometry-based proteomics technology has been extensively used in the analysis of biological f...
