Ena izmed pomembnih reakcij v klik kemiji je 1,3-dipolarna cikloadicija, ki spada med periciklične reakcije. Cikloadicija se uporablja za sintezo heterocikličnih sistemov z lihim številom atomov v obroču. V uvodu diplomskega dela se bom posvetil lastnostim in sintezi azometin iminov in pirazolidin-3-onom, ki lahko služijo kot izhodne spojine za pri...
Published in ACS applied bio materials
Photoactivities and photoinduced antibacterial functions of two vitamin B2 (VB2) derivatives, riboflavin (RF) and flavin mononucleotide (FMN), were investigated by computational modeling and various experimental evaluations. Under photoirradiation, the ground state of both VB2 derivatives could be excited to generate different reactive oxygen speci...
Redoks reakcije, ki potečejo po absorpciji fotonov, omogočajo pripravo in funkcionalizacijo heterocikličnih spojin pod blagimi reakcijskimi pogoji. Od teh smo se osredotočili na pretvorbe spojin s pirazolnim skeletom. Pod vidno svetlobo v prisotnosti fotoredoks katalizatorja eozina ter kisika kot oksidanta smo uspešno oksidirali 1-substituirane pir...
Published in Biophysics and Physicobiology
PYP-phytochrome related (Ppr) protein contains the two light sensor domains, photoactive yellow protein (PYP) and bacteriophytochrome (Bph), which mainly absorb blue and red light by the chromophores of p -coumaric acid ( p CA) and biliverdin (BV), respectively. As a result, Ppr has the ability to photoactivate both domains together or separately. ...
Bakalářská práce se zabývá rozdíly mezi viděním člověka a vybraných druhů živočichů. První polovina je věnována teoretické části, která popisuje základní anatomickou a fyziologickou stavbu oka, dále také centrální a periferní vidění, akomodaci a v neposlední řádě se zaměřuje na vnímání barev, jenž se dělí dle teorie oponentního procesu a teorie tri...
Published in Russian Chemical Bulletin
The sodium and bis(arene)chromium salts of monosubstituted hydrofullerides, containing bis(3,4-dimethoxyphenyl)phenylmethane, 2,6-bis(4-methoxyphenyl)-4-phenylpyridine, 15-crown-5, N-ethyl-N-phenylbenzamide moieties, were synthesized and theirs NIR spectrum were investigated.
Published in Angewandte Chemie (International ed. in English)
A mild, atom-economic, and metal-free α-C-H amination of ethers using relatively stable nonafluorobutanesulfonyl (nonaflyl, Nf) azide as the aminating reagent to give N-sulfonyl hemiaminals is reported. This enables unprecedented C(sp3 ) difunctionalization reactions, leading to diverse functionalized amino group containing compounds starting from ...
Published in Russian Chemical Bulletin
Indolizidinofullerenes containing trimethoxyarene substituents in the indolizidine cycle, 1-amidoalkylfullerenes, and their ion-radical salts with bis(arene)chromium complexes were synthesized. The compounds obtained were characterized by a number of spectral methods.
Published in Angewandte Chemie (International ed. in English)
N-Acyliminoiodinanes were characterized for the first time by X-ray structural analysis. The ortho-methoxymethyl group and the carbonyl oxygen coordinate to the iodine atom of the iminoiodinane. Activation of the N-acyliminoiodinane was achieved by photoirradiation at 370 nm, thereby enabling reaction with various silyl enol ethers to give α-aminok...
Published in Angewandte Chemie (International ed. in English)
The photoinduced regio- and enantioselective coupling of naphthols and derivatives thereof is achieved in the confined chiral coordination space of a RuII metalloligand based cage. The racemic or enantiopure cages encapsulate naphthol guests, which then undergo a regiospecific 1,4-coupling, rather than the normal 1,1-coupling, to form 4-(2-hydroxy-...
