Dietze, Raimund Hammoud, Mohamad K. Gómez-Serrano, María Unger, Annika Bieringer, Tim Finkernagel, Florian Sokol, Anna M. Nist, Andrea Stiewe, Thorsten Reinartz, Silke
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Published in
Theranostics
Arachidonic acid (AA) is a polyunsaturated fatty acid present at high concentrations in the ovarian cancer (OC) microenvironment and associated with a poor clinical outcome. In the present study, we have unraveled a potential link between AA and macrophage functions. Methods: AA-triggered signal transduction was studied in primary monocyte-derived ...
Hekman, Ryan M Hume, Adam J Goel, Raghuveera Kumar Abo, Kristine M Huang, Jessie Blum, Benjamin C Werder, Rhiannon B Suder, Ellen L Paul, Indranil Phanse, Sadhna
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Published in
Molecular cell
Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative pathogen of the COVID-19 pandemic, exerts a massive health and socioeconomic crisis. The virus infects alveolar epithelial type 2 cells (AT2s), leading to lung injury and impaired gas exchange, but the mechanisms driving infection and pathology are unclear...
Ding, Lianhong Xie, Shaoshuai Zhang, Shucui Shen, Hangyu Zhong, Huaqiang Li, Daoyuan Shi, Peng Chi, Lianli Zhang, Qunye
Published in
Frontiers in Molecular Biosciences
Analysis of high-throughput omics data is one of the most important approaches for obtaining information regarding interactions between proteins/genes. Time-series omics data are a series of omics data points indexed in time order and normally contain more abundant information about the interactions between biological macromolecules than static omi...
Liu, Yongbo Fu, Cheng Ye, Shaotang Liang, Yingxin Qi, Zhonghe Yao, Congwen Wang, Zhen Wang, Ji Cai, Siqi Tang, Shiyu
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Published in
Frontiers in Veterinary Science
Avian-origin H3N2 canine influenza viruses (CIVs) cause severe contagious respiratory disease in dogs, and quickly adapt to new environments. To further understand the mechanism of virus infection and host-virus interactions, we characterized the complete phosphoproteome of dogs infected with H3N2 CIV. Nine-week-old Beagle dogs were inoculated intr...
Morshed, Nader Ralvenius, William T Nott, Alexi Watson, L Ashley Rodriguez, Felicia H Akay, Leyla A Joughin, Brian A Pao, Ping-Chieh Penney, Jay LaRocque, Lauren
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Published in
Molecular systems biology
Alzheimer's disease (AD) is characterized by the appearance of amyloid-β plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Using mass spectrometry, we have quantified the phosphoproteome of the CK-p25, 5XFAD, and Tau P301S mouse models of neurodegeneration. We identified a shared response involving Siglec-F whi...
Frazier, Katya Frith, Mary Harris, Dylan Leone, Vanessa A
Published in
Biology
Circadian rhythms are essential for nearly all life forms, mediated by a core molecular gene network that drives downstream molecular processes involved in immune function and metabolic regulation. These biological rhythms serve as the body's metronome in response to the 24-hour light:dark cycle and other timed stimuli. Disrupted circadian rhythms ...
Sakr, Hussein F Hussein, Abdelaziz M Eid, Elsayed A Boudaka, Ammar Lashin, Lashin S
Published in
Veterinary sciences
The present study examined the effect DHEA (dehydroepiandrosterone) on bone mineral content (BMC) and bone mineral density (BMD) and biomarkers of bone remodeling in orchidectomized male rats. A total of 32 male rats were divided equally into four groups (n = 8): (i) control group (C), (ii) control treated with DHEA (Control + DHEA), (iii) orchidec...
Abyadeh, Morteza Meyfour, Anna Gupta, Vivek Zabet Moghaddam, Masoud Fitzhenry, Matthew J Shahbazian, Shila Hosseini Salekdeh, Ghasem Mirzaei, Mehdi
Published in
International journal of molecular sciences
Gastrointestinal (GI) cancer remains one of the common causes of morbidity and mortality. A high number of cases are diagnosed at an advanced stage, leading to a poor survival rate. This is primarily attributed to the lack of reliable diagnostic biomarkers and limited treatment options. Therefore, more sensitive, specific biomarkers and curative tr...
Raghuram, Viswanathan Salhadar, Karim Limbutara, Kavee Park, Euijung Yang, Chin-Rang Knepper, Mark A
Published in
American journal of physiology. Renal physiology
Vasopressin regulates osmotic water transport in the renal collecting duct by protein kinase A (PKA)-mediated control of the water channel aquaporin-2 (AQP2). Collecting duct principal cells express two seemingly redundant PKA catalytic subunits, PKA catalytic α (PKA-Cα) and PKA catalytic β (PKA-Cβ). To identify the roles of these two protein kinas...
Okuyama, Tomoko Shirakawa, Jun Tajima, Kazuki Ino, Yoko Vethe, Heidrun Togashi, Yu Kyohara, Mayu Inoue, Ryota Miyashita, Daisuke Li, Jinghe
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Published in
International Journal of Molecular Sciences
Abnormal hepatic insulin signaling is a cause or consequence of hepatic steatosis. DPP-4 inhibitors might be protective against fatty liver. We previously reported that the systemic inhibition of insulin receptor (IR) and IGF-1 receptor (IGF1R) by the administration of OSI-906 (linsitinib), a dual IR/IGF1R inhibitor, induced glucose intolerance, he...
