Feng, Yihong Endo, Masayuki Sugiyama, Hiroshi
Nucleosomes, which are the fundamental building blocks of chromatin, are highly dynamic and play vital roles in the formation of higher‐order chromatin structures and orchestrate gene regulation. Nucleosome structures, histone modifications, nucleosome‐binding proteins, and their functions are being gradually unravelled with the development of epig...
Feng, Yihong Endo, Masayuki Sugiyama, Hiroshi
Published in
Chembiochem : a European journal of chemical biology
Nucleosomes, which are the fundamental building blocks of chromatin, are highly dynamic, they play vital roles in the formation of higher-order chromatin structures and orchestrate gene regulation. Nucleosome structures, histone modifications, nucleosome-binding proteins, and their functions are being gradually unravelled with the development of ep...
Sheppard, Hadley E. Dall’Agnese, Alessandra Park, Woojun D. Shamim, M. Hamza Dubrulle, Julien Johnson, Hannah L. Stossi, Fabio Cogswell, Patricia Sommer, Josh Levy, Joan
...
Published in
Cell Reports Medicine
Sheppard et al. map the brachyury regulatory landscape in chordoma and explore its targeting using transcriptional CDK inhibition and targeted brachyury degradation. Brachyury is a highly selective transcriptional regulator of chordoma identity, and they confirm that brachyury targeting is a promising therapeutic strategy.
Bui, Van-Tien Nguyen, Van-Toan Nguyen, Ngoc-Anh Umapathi, Reddicherla Larina, Liudmila L. Kim, Jong Heon Kim, Hyun-Suk Choi, Ho-Suk
Published in
Membranes
The development of highly porous and thin separator is a great challenge for lithium-ion batteries (LIBs). However, the inevitable safety issues always caused by poor mechanical integrity and internal short circuits of the thin separator must be addressed before this type of separator can be applied to lithium-ion batteries. Here, we developed a no...
Birnie, Anthony Dekker, Cees
Published in
ACS Nano
Chromosome structure and dynamics are essential for life, as the way that our genomes are spatially organized within cells is crucial for gene expression, differentiation, and genome transfer to daughter cells. There is a wide variety of methods available to study chromosomes, ranging from live-cell studies to single-molecule biophysics, which we b...
Pan, Qi Sun, Daxiao Xue, Jianfeng Hao, Jie Zhao, Hansen Lin, Xijian Yu, Li He, Yan
Published in
ACS nano
Liquid-liquid phase separation (LLPS) underlies the formation mechanism of membraneless biomolecular condensates locally to perform important physiological functions such as selective autophagy, but little is known about the relationship between their dynamic structural organization and biophysical properties. Here, a dark-field microscopy based si...
Salladini, Edoardo Jørgensen, Maria L. M. Theisen, Frederik F. Skriver, Karen
Published in
International Journal of Molecular Sciences
Eukaryotic cells are complex biological systems that depend on highly connected molecular interaction networks with intrinsically disordered proteins as essential components. Through specific examples, we relate the conformational ensemble nature of intrinsic disorder (ID) in transcription factors to functions in plants. Transcription factors conta...
Carlson, Christopher R Asfaha, Jonathan B Ghent, Chloe M Howard, Conor J Hartooni, Nairi Safari, Maliheh Frankel, Alan D Morgan, David O
Published in
Molecular cell
The nucleocapsid (N) protein of coronaviruses serves two major functions: compaction of the RNA genome in the virion and regulation of viral gene transcription. It is not clear how the N protein mediates such distinct functions. The N protein contains two RNA-binding domains surrounded by regions of intrinsic disorder. Phosphorylation of the centra...
Acharya, Shashidhara Chatterjee, Abhijit Seema, Gupta, Mukul Saha, Bivas
Published in
Bulletin of Materials Science
Wurtzite–Al1−xScxN thin films deposited by solid-state alloying of AlN with ScN exhibit high piezoelectric coefficient and large band gap that makes it a promising material for a variety of applications in piezo-electronics, electronic, acoustoelectric devices, etc. Research on epitaxial Al1−xScxN growth in wurtzite crystal structure is still at an...
Wiegand, Tina Hyman, Anthony A
Published in
Emerging topics in life sciences
The cellular cytoskeleton self-organizes by specific monomer-monomer interactions resulting in the polymerization of filaments. While we have long thought about the role of polymerization in cytoskeleton formation, we have only begun to consider the role of condensation in cytoskeletal organization. In this review, we highlight how the interplay be...