Pradhan, Deepak Biswasroy, Prativa Goyal, Amit Ghosh, Goutam Rath, Goutam
Published in
AAPS PharmSciTech
In the last few decades, the exponential rise in the incidence of viral infections sets a global health emergency across the world. The biomimetic architecture, the ability to hijack host immune responses, continuous antigen shifting, and drafting are the major critical factors that are responsible for the unavailability of a concrete therapeutic r...
Stella, Stefania Massimino, Michele Manzella, Livia Pennisi, Maria Stella Tirrò, Elena Romano, Chiara Vitale, Silvia Rita Puma, Adriana Tomarchio, Cristina Gregorio, Sandra Di
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Published in
International journal of molecular sciences
Hypereosinophilia (HE) is a heterogeneous condition with a persistent elevated eosinophil count of >350/mm3, which is reported in various (inflammatory, allergic, infectious, or neoplastic) diseases with distinct pathophysiological pathways. HE may be associated with tissue or organ damage and, in this case, the disorder is classified as hypereosin...
Kalisz, Grzegorz Przekora, Agata Kazimierczak, Paulina Gieroba, Barbara Jedrek, Michal Grudzinski, Wojciech Gruszecki, Wieslaw I Ginalska, Grazyna Sroka-Bartnicka, Anna
Published in
International journal of molecular sciences
Raman spectroscopic imaging and mapping were applied to characterise three-compound ceramic composite biomaterial consisting of chitosan, β-1,3-d-glucan (curdlan) and hydroxyapatite (HA) developed as a bone tissue engineering product (TEP). In this rapidly advancing domain of medical science, the urge for quick, reliable and specific method for pro...
Pepin, Xavier J. H. Huckle, James E. Alluri, Ravindra V. Basu, Sumit Dodd, Stephanie Parrott, Neil Emami Riedmaier, Arian
Published in
The AAPS Journal
Over the last 10 years, 40% of approved oral drugs exhibited a significant effect of food on their pharmacokinetics (PK) and currently the only method to characterize the effect of food on drug absorption, which is recognized by the authorities, is to conduct a clinical evaluation. Within the pharmaceutical industry, there is a significant effort t...
Wang, Bing Yang, Liuliu Wang, Bing Luo, Chunlin Wang, Yuhan Wang, Hao Chen, Fang Xiang, Xiaoqiang
Published in
AAPS PharmSciTech
The present study endeavored to develop orodispersible films (ODFs) containing 30 mg racecadotril for pediatric use, which focuses on improving the compliance of pediatric patients and reducing risk of choking. The challenge of this study is to prepare high drug loading ODFs with successful mechanical and physicochemical properties. Compatibilities...
Hanžel, Jurij; Zdovc, Jurij; Kurent, Tina; Sever, Nejc; Javornik, Katarina; Tuta, Katja; Koželj, Matic; Smrekar, Nataša; Novak, Gregor; Štabuc, Borut;
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BACKGROUND & AIMS: Little is known about the relationship between ustekinumab exposure during the first 2 weeks of treatment and outcomes of patients with Crohn's disease (CD). We investigated the relationship between serum concentrations of ustekinumab during the first 2 weeks of treatment and endoscopic and biochemical remission in patients with ...
Dong, Wenliang Chen, Min Wang, Jiaxue Xia, Lin Wang, Qian Nie, Xiaoyan Feng, Yufei Fang, Yi
Published in
Immunotherapy
Aim: This meta-analysis aimed to evaluate the pharmacokinetics, efficacy, safety and immunogenicity of rHuPH20-facilitated subcutaneous (SC) administration of monoclonal antibody compared with intravenous (IV) administration for patients with cancer. Materials & methods: Outcomes included trough concentrations (Ctrough), overall response rate, adve...
Takubo, Hiroaki Taniguchi, Toshio Iwanaga, Kazunori Nomura, Yukihiro
Published in
Xenobiotica; the fate of foreign compounds in biological systems
Targeted covalent inhibitors designed to bind covalently to a specific molecular target have recently been a focus of drug development. Among these inhibitors, thiol compounds bind covalently to endogenous thiols in the body through a process involving disulfide bonds. We investigated the predictability of changes in the exposure to captopril, tiop...
Song, Yeong Wook Park, Yong-Beom Kim, Jinseok
Published in
Expert opinion on biological therapy
Introduction: Treatment of rheumatoid arthritis (RA) has been revolutionized by the introduction of biologic disease-modifying antirheumatic drugs, such as tumor necrosis factor (TNF) inhibitors. With patent expiry approaching for many expensive biologic molecules, such as etanercept, more affordable biosimilar drugs are being developed. LBEC0101 i...
Ippolito, Matthew M Flexner, Charles
Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America