Brito-da-Costa, Andreia Machado Dias-da-Silva, Diana Gomes, Nelson G M Dinis-Oliveira, Ricardo Jorge Madureira-Carvalho, Áurea
Published in
Pharmaceuticals (Basel, Switzerland)
Salvia divinorum Epling and Játiva is a perennial mint from the Lamiaceae family, endemic to Mexico, predominantly from the state of Oaxaca. Due to its psychoactive properties, S. divinorum had been used for centuries by Mazatecans for divinatory, religious, and medicinal purposes. In recent years, its use for recreational purposes, especially amon...
Ali, Adel A Hassan, Amira H Eissa, Essam M Aboud, Heba M
Published in
International Journal of Nanomedicine
Purpose The aim of the present study was to develop deflazacort (DFZ) ultra-elastic nanovesicles (UENVs) loaded gel for topical administration to evade gastrointestinal adverse impacts accompanying DFZ oral therapy. Methods UENVs were elaborated according to D-optimal mixture design employing different edge activators as Span-60, Tween-85 and sodiu...
Piscatelli, Joseph A. Ban, Jisun Lucas, Andrew T. Zamboni, William C.
Published in
Pharmaceutics
Major developments in nanomedicines, such as nanoparticles (NPs), nanosomes, and conjugates, have revolutionized drug delivery capabilities over the past four decades. Although nanocarrier agents provide numerous advantages (e.g., greater solubility and duration of systemic exposure) compared to their small-molecule counterparts, there is considera...
Bonassa, Karina P D Miragliotta, Miwa Y Simas, Rosineide C Eberlin, Marcos N Anadón, Arturo Moreno, Ronilson A Reyes, Felix G R
Published in
Frontiers in veterinary science
Pharmacokinetic parameters and efficacy prediction indexes (Cmax/MIC90 and AUC0-24/MIC90) of an enrofloxacin hydrochloride (ENR-HCl) veterinary product soluble in water were determined in healthy broiler chickens of both sexes after a single oral dose of ENR-HCl (equivalent to 10 mg ENR base/kg bw). Monte Carlo simulations targeting Cmax/MIC90 = 10...
Lamoth, Frederic Lewis, Russell E. Kontoyiannis, Dimitrios P.
Published in
Journal of Fungi
Invasive fungal infections (IFIs) are associated with high mortality rates and timely appropriate antifungal therapy is essential for good outcomes. Emerging antifungal resistance among Candida and Aspergillus spp., the major causes of IFI, is concerning and has led to the increasing incorporation of in vitro antifungal susceptibility testing (AST)...
Moury, Benoît Desbiez, Cécile
Published in
Viruses
Virus host range, i.e., the number and diversity of host species of viruses, is an important determinant of disease emergence and of the efficiency of disease control strategies. However, for plant viruses, little is known about the genetic or ecological factors involved in the evolution of host range. Using available genome sequences and host rang...
He, Xiaoying Li, Guowei Chen, Yuanyuan Xiao, Qiming Yu, Xinwei Yu, Xixi Lu, Xiaoyang Xiang, Zheng
Published in
Frontiers in Pharmacology
Objectives: The interaction between the components of traditional Chinese medicine (TCM) is an important basis for their synergy. Rhein and curcumin exert various pharmacological activities, including anti-tumour, anti-inflammatory, antioxidant, anti-fibrosis and renoprotective effects. However, no investigation has reported the synergistic anti-fi...
Berezhnoy, Alexey Sumrow, Bradley J. Stahl, Kurt Shah, Kalpana Liu, Daorong Li, Jonathan Hao, Su-Shin De Costa, Anushka Kaul, Sanjeev Bendell, Johanna
...
Published in
Cell Reports Medicine
Co-blockade of PD-1 and CTLA-4 increases benefits in cancer immunotherapy but also its toxicity. Berezhnoy et al. constructed a bispecific DART molecule to deliver safer and potentially more effective co-blockade by targeting CTLA-4 inhibition to tumors. MGD019 demonstrates encouraging activity in tumors traditionally unresponsive to checkpoint blo...
Krumpl, Günther Ulč, Ivan Trebs, Michaela Hodisch, Juri Kadlecová, Pavla Husch, Bernhard
Published in
Cureus
Background and objective This study involved an investigation into the pharmacokinetic and pharmacodynamic behavior of esmolol in the presence of dobutamine in healthy subjects of European ancestry. Methods We conducted a single-center, prospective randomized study of 16 healthy subjects with each receiving an infusion of dobutamine sufficient to i...
Simon, Philipp Petroff, David Busse, David Heyne, Jana Girrbach, Felix Dietrich, Arne Kratzer, Alexander Zeitlinger, Markus Kloft, Charlotte Kees, Frieder
...
Published in
Antibiotics
Background: This controlled clinical study aimed to investigate the impact of obesity on plasma and tissue pharmacokinetics of meropenem. Methods: Obese (body mass index (BMI) ≥ 35 kg/m2) and age-/sex-matched nonobese (18.5 kg/m2 ≥ BMI ≤ 30 kg/m2) surgical patients received a short-term infusion of 1000-mg meropenem. Concentrations were determined ...
