Sałaga, M. Mokrowiecka, A. Zakrzewski, P.K. Cygankiewicz, A. Leishman, E. Sobczak, M. Zatorski, H. Małecka-Panas, E. Kordek, R. Storr, M.
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Published in
Journal of Crohn's and Colitis
Background and aimsPharmacological treatment and/or maintenance of remission in inflammatory bowel diseases (IBD) is currently one of the biggest challenge in the field of gastroenterology. Available therapies are mostly limited to overcoming the symptoms, but not the cause of the disease. Recently, the endocannabinoid system has been proposed as a...
Burghard, Alice Lenarz, Thomas Kral, Andrej Paasche, Gerrit
Published in
Hearing Research
•Cochlear implantation via the round window membrane (RWM) or a cochleostomy.•Sealing material: no additional sealing, muscle graft or carboxylate cement.•Hearing thresholds correlated with the amount of tissue formation.•The RWM approach resulted in less tissue formation than the cochleostomy approach.•Carboxylate cement sealing resulted in a stro...
César, Isabela C. Godin, Adriana M. Araujo, Débora P. Oliveira, Francinely C. Menezes, Raquel R. Santos, Julliana R.A. Almeida, Mariana O. Dutra, Marcela M.G.B. Santos, Daniel A. Machado, Renes R.
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Published in
Bioorganic & Medicinal Chemistry
Nicorandil (N-(2-hydroxyethyl)nicotinamide nitrate) is an antianginal drug, which activates guanylyl cyclase and opens the ATP-dependent K+ channels, actions that have been suggested to mediate its vasodilator activity. We synthesized nicorandil and its two isomers, which vary in the positions of the side chain containing the nitric oxide (NO) dono...
Di Fabio, Romano Alvaro, Giuseppe Braggio, Simone Carletti, Renzo Gerrard, Philip A Griffante, Cristiana Marchioro, Carla Pozzan, Alfonso Melotto, Sergio Poffe, Alessandro
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Published in
Bioorganic & medicinal chemistry
The last two decades have provided a large weight of preclinical data implicating the neurokinin-1 receptor (NK1) and its cognate ligand substance P (SP) in a broad range of both central and peripheral disease conditions. However, to date, only the NK1 receptor antagonist aprepitant has been approved as a therapeutic and this is to prevent chemothe...
Kobayashi, Yuki Fukami, Tatsuki Higuchi, Ryota Nakajima, Miki Yokoi, Tsuyoshi
Published in
Biochemical Pharmacology
Phenacetin has been used as an analgesic antipyretic but has now been withdrawn from the market due to adverse effects such as methemoglobinemia and renal failure. It has been suggested that metabolic activation causes these adverse effects; yet, the precise mechanisms remain unknown. We previously demonstrated that human arylacetamide deacetylase ...
Scott, Victoria E. Vortherms, Timothy A. Niforatos, Wende Swensen, Andrew M. Neelands, Torben Milicic, Ivan Banfor, Patricia N. King, Andrew Zhong, Chengmin Simler, Gricelda
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Published in
Biochemical Pharmacology
Blockade of voltage-gated Ca 2+ channels on sensory nerves attenuates neurotransmitter release and membrane hyperexcitability associated with chronic pain states. Identification of small molecule Ca 2+ channel blockers that produce significant antinociception in the absence of deleterious hemodynamic effects has been challenging. In this report, tw...
Galeotti, Nicoletta Vivoli, Elisa Bilia, Anna Rita Vincieri, Franco Francesco Ghelardini, Carla
Published in
Biochemical Pharmacology
Current pharmacological treatments for neuropathic pain have limited efficacy and severe side-effect limitations. St. John's Wort (SJW) is a medicinal plant, mainly used as antidepressant, with a favourable side-effect profile. We here demonstrate the ability of SJW to relieve neuropathic pain in rat models. The antihyperalgesic profile and mechani...
Eaton, D.L. Beima, K.M. Bammler, T.K. Riley, R.T. Voss, K.A.
Published in
Comprehensive Toxicology
Mycotoxins are secondary metabolites of fungi. Aflatoxins represent one of the most important classes of hepatotoxic mycotoxins known to adversely affect human health. Aflatoxins are the most potent identified mycotoxins and are produced by three fungal species: the common fungal molds Aspergillus flavus and Aspergillus parasiticus, and the rare fu...
Dai, Chun-ling Liang, Yong-ju Chen, Li-ming Zhang, Xu Deng, Wen-jing Su, Xiao-dong Shi, Zhi Wu, Chung-pu Ashby, Charles R. Jr. Akiyama, Shin-ichi
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Published in
Biochemical Pharmacology
The effectiveness of chemotherapeutic treatment is usually limited by the overexpression of adenosine triphosphate binding cassette (ABC) transporters, which mediate multidrug resistance (MDR) by acting as efflux pumps to remove chemotherapeutic agents from MDR cancer cells. Thus, the inhibition of ABC transporters may represent a promising strateg...
Daniel, J.-P. Moulin, B. Christmann, D.
Published in
Annales Pharmaceutiques Francaises
Fluoroquinolones present various pharmacokinetic properties. That's the way we carried out a bibliographic summary about the pharmacokinetics of pefloxacin, ofloxacin and ciprofloxacin in patients hit by chronic renal failure, under haemodialysis or under continuous ambulatory peritoneal dialysis. Then, we will describe how to adapt drug dose accor...
