Published in Viruses
Griffithsin (GRFT) is a red alga-derived lectin with demonstrated broad spectrum antiviral activity against enveloped viruses, including severe acute respiratory syndrome-Coronavirus (SARS-CoV), Japanese encephalitis virus (JEV), hepatitis C virus (HCV), and herpes simplex virus-2 (HSV-2). However, its pharmacokinetic profile remains largely undefi...
Published in Journal of Crohn's and Colitis
Background and aimsPharmacological treatment and/or maintenance of remission in inflammatory bowel diseases (IBD) is currently one of the biggest challenge in the field of gastroenterology. Available therapies are mostly limited to overcoming the symptoms, but not the cause of the disease. Recently, the endocannabinoid system has been proposed as a...
Published in Journal of Crohn's and Colitis
Published in Bioorganic & Medicinal Chemistry
Nicorandil (N-(2-hydroxyethyl)nicotinamide nitrate) is an antianginal drug, which activates guanylyl cyclase and opens the ATP-dependent K+ channels, actions that have been suggested to mediate its vasodilator activity. We synthesized nicorandil and its two isomers, which vary in the positions of the side chain containing the nitric oxide (NO) dono...
Published in Hearing Research
Published in Bioorganic & Medicinal Chemistry
Published in Hearing Research
•Cochlear implantation via the round window membrane (RWM) or a cochleostomy.•Sealing material: no additional sealing, muscle graft or carboxylate cement.•Hearing thresholds correlated with the amount of tissue formation.•The RWM approach resulted in less tissue formation than the cochleostomy approach.•Carboxylate cement sealing resulted in a stro...
Published in Bioorganic & medicinal chemistry
The last two decades have provided a large weight of preclinical data implicating the neurokinin-1 receptor (NK1) and its cognate ligand substance P (SP) in a broad range of both central and peripheral disease conditions. However, to date, only the NK1 receptor antagonist aprepitant has been approved as a therapeutic and this is to prevent chemothe...
Published in Biochemical Pharmacology
Phenacetin has been used as an analgesic antipyretic but has now been withdrawn from the market due to adverse effects such as methemoglobinemia and renal failure. It has been suggested that metabolic activation causes these adverse effects; yet, the precise mechanisms remain unknown. We previously demonstrated that human arylacetamide deacetylase ...
Published in Biochemical Pharmacology
Blockade of voltage-gated Ca 2+ channels on sensory nerves attenuates neurotransmitter release and membrane hyperexcitability associated with chronic pain states. Identification of small molecule Ca 2+ channel blockers that produce significant antinociception in the absence of deleterious hemodynamic effects has been challenging. In this report, tw...
