Cobe, Brandi L. Dey, Supratim Minasov, George Inniss, Nicole Satchell, Karla J. F. Cianciotto, Nicholas P.
Published in
mBio
Stenotrophomonas maltophilia is a multi-drug-resistant, Gram-negative bacterium that is an emerging pathogen of humans. Patients with cystic fibrosis are particularly susceptible to S. maltophilia infection. In hospital water systems and various types of infections, S. maltophilia co-exists with other bacteria, including other pathogens such as Pse...
Sanz-Gaitero, Marta; De Maesschalck, Vincent; 132796; Patel, Ankur; Longin, Hannelore; 148057; Van Noort, Vera; 89822; Rodriguez-Rubio, Lorena; van Ryne, Michael; Danis-Wlodarczyk, Katarzyna; Drulis-Kawa, Zuzanna; Mesnage, Stephane;
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BACKGROUND: Endolysins are phage-encoded lytic enzymes that degrade bacterial peptidoglycan at the end of phage lytic cycles to release new phage particles. These enzymes are being explored as an alternative to small-molecule antibiotics. METHODS: The crystal structure of KTN6 Gp46 was determined and compared with a ColabFold model. Cleavage specif...
Roehrig, Christian Huemer, Markus Lorgé, Dominique Arn, Fabienne Heinrich, Nadine Selvakumar, Lavanja Gasser, Lynn Hauswirth, Patrick Chang, Chun-Chi Schweizer, Tiziano A.
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Published in
mBio
One of the most pressing challenges of our era is the rising occurrence of bacteria that are resistant to antibiotics. Staphylococci are prominent pathogens in humans, which have developed multiple strategies to evade the effects of antibiotics. Infections caused by these bacteria have resulted in a high burden on the health care system and a signi...
Keller, Anja P. Huemer, Markus Chang, Chun-Chi Mairpady Shambat, Srikanth Bjurnemark, Caroline Oberortner, Nicole Santschi, Michaela V. Zinsli, Léa V. Röhrig, Christian Sobieraj, Anna M.
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Published in
mBio
The rising prevalence of antimicrobial resistance in S. aureus has rendered treatment of staphylococcal infections increasingly difficult, making the discovery of alternative treatment options a high priority. Peptidoglycan hydrolases, a diverse group of bacteriolytic enzymes, show high promise as such alternatives due to their rapid and specific l...
Choi, Umji Park, Si Hyoung Lee, Han Byeol Son, Ji Eun Lee, Chang-Ro
Published in
Microbiology Spectrum
Peptidoglycan (PG) is an essential bacterial architecture pivotal for shape maintenance and adaptation to osmotic stress. Although PG synthesis and modification are tightly regulated under harsh environmental stresses, few related mechanisms have been investigated. In this study, we aimed to investigate the coordinated and distinct roles of the PG ...
Frirdich, Emilisa Vermeulen, Jenny Biboy, Jacob Vollmer, Waldemar Gaynor, Erin C.
Published in
Frontiers in Microbiology
Campylobacter jejuni is a Gram-negative helical bacterium. Its helical morphology, maintained by the peptidoglycan (PG) layer, plays a key role in its transmission in the environment, colonization, and pathogenic properties. The previously characterized PG hydrolases Pgp1 and Pgp2 are important for generating C. jejuni helical morphology, with dele...
Lu, Shao-Yeh Liu, Siqing Patel, Maulik H. Glenzinski, Kristina M. Skory, Christopher D.
Published in
Frontiers in Bioengineering and Biotechnology
Control of bacterial contamination in bioethanol fermentation facilities has traditionally relied on chemical-based products such as hop acids and use of antibiotics. Recent emphasis on antibiotic stewardship has prompted new research into the development of alternative approaches to microbial remediation strategies. We recently described a recombi...
Chino de la Cruz, Citlali Melissa Cornejo-Granados, Fernanda Gallardo-Becerra, Luigui Rodríguez-Alegría, María Elena Ochoa-Leyva, Adrian López Munguía, Agustín
Published in
Microbial genomics
Litopenaeus vannamei, the Pacific whiteleg shrimp, is one of the most marketable species in aquaculture worldwide. However, it is susceptible to different infections causing considerable losses in production each year. Consequently, using prebiotics that promotes the proliferation of beneficial bacteria and strengthen the immune system is a current...
Liu, Yilan Chen, Jinjin Raj, Kaushik Baerg, Lauren Nathan, Nayanan Philpott, Dana J Mahadevan, Radhakrishnan
Published in
ACS synthetic biology
Both Gram-positive and Gram-negative bacteria release nanosized extracellular vesicles called membrane vesicles (MVs, 20-400 nm), which have great potential in various biomedical applications due to their abilities to deliver effector molecules and induce therapeutic responses. To fully utilize bacterial MVs for therapeutic purposes, regulated and ...
Xie, Yunfeng Wang, Lei Yang, Yang Zha, Liang Zhang, Jiazhen Rong, Kuanrong Tang, Wenjian Zhang, Jing
Published in
Frontiers in Microbiology
Enterococcus faecium (E. faecium) is a clinical multidrug-resistant pathogen causing life-threatening infection, which makes it important to discover antibacterial agents with novel scaffolds and unique mechanism. In this study, the diarylurea scaffold was found to have potent antibacterial effect on E. faecium. Diarylurea ZJ-2 with benign drug-lik...
