Tušar, Teja
Peptidi so na trgu kozmetičnih izdelkov prisotni že skoraj 50 let. V tem času so se nekateri peptidi uveljavili kot učinkovite aktivne sestavine za široko področje kožnih problematik. Peptide sestavlja do 100 aminokislin, ki so med seboj povezane s peptidno vezjo. Nekateri peptidi niso sposobni prehajati rožene plasti in so tako odlični tvorilci fi...
Davis, Ryan A Hausner, Sven H Harris, Rebecca Sutcliffe, Julie L
Published in
Pharmaceutics
Serum albumin binding moieties (ABMs) such as the Evans blue (EB) dye fragment and the 4-(p-iodophenyl)butyryl (IP) have been used to improve the pharmacokinetic profile of many radiopharmaceuticals. The goal of this work was to directly compare these two ABMs when conjugated to an integrin αvβ6 binding peptide (αvβ6-BP); a peptide that is currentl...
Anagnostaras, Stephan G. Wood, Suzanne C. Shuman, Tristan Cai, Denise J. LeDuc, Arthur D. Zurn, Karl R. Zurn, J. Brooks Sage, Jennifer R. Herrera, Gerald M.
Published in
Frontiers in Behavioral Neuroscience
The Pavlovian conditioned freezing paradigm has become a prominent mouse and rat model of learning and memory, as well as of pathological fear. Due to its efficiency, reproducibility and well-defined neurobiology, the paradigm has become widely adopted in large-scale genetic and pharmacological screens. However, one major shortcoming of the use of ...
Li, Jingjing Shu, Yiyi Li, Chongning Jiang, Zhiliang
Published in
Frontiers in Nutrition
High affinity peptides (PTs) have been used in nanoanalysis, but there are no reports which combine PTs with a liquid crystal (LC) covalent organic framework (COF) supported soluble starch (SS) catalytic amplification system as a biosensor recognition element. In this study, a new, highly sensitive and selective bi-mode molecular biosensor has been...
Huang, Meijia Yang, Fan Wu, Yong Meng, Xuanyi Shi, Linbo Chen, Hongbing Li, Xin
Published in
Frontiers in Nutrition
Analysis of epitope peptides in yogurts.
Dugyala, Supritha Ptacek, Travis S. Simon, Jeremy M. Li, Yuhui Fröhlich, Flavio
Published in
Animal Microbiome
BackgroundIncreasing evidence suggests a causal relationship between the gut microbiome and psychiatric illnesses. In particular, autism spectrum disorder is associated with gastrointestinal symptoms and alterations in the gut microbiome. Administration of probiotics is a commonly used strategy by caregivers of people with neurodevelopmental illnes...
Cary, Brian P Zhang, Xin Cao, Jianjun Johnson, Rachel M Piper, Sarah J Gerrard, Elliot J Wootten, Denise Sexton, Patrick M
Published in
Endocrine reviews
G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors. Class B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large extracellular domains (ECDs) and respond to long polypeptide hormones. Class B1 GPCRs are critical regulators of homeostasis, and as such, many are important drug targets. ...
Vogt, Eva Sonderegger, Lukas Chen, Ying-Yu Segessemann, Tina Künzler, Markus
Published in
Microbiology Spectrum
Bioactivities of fungal peptides are of interest for basic research and therapeutic drug development. Some of these peptides are derived from “KEX2-processed repeat proteins” (KEPs), a recently defined class of precursor proteins that contain multiple peptide cores flanked by KEX2 protease cleavage sites. Genome mining has revealed that KEPs are wi...
Beeren, Ivo A O Dijkstra, Pieter J Lourenço, Ana Filipa H Sinha, Ravi Gomes, David B Liu, Hong Bouvy, Nicole Baker, Matthew B Camarero-Espinosa, Sandra Moroni, Lorenzo
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Published in
Biofabrication
Melt extrusion-based additive manufacturing (AM) is often used to fabricate scaffolds for osteochondral (OC) regeneration. However, there are two shortcomings associated with this scaffold manufacturing technique for engineering of tissue interfaces: (a) most polymers used in the processing are bioinert, and (b) AM scaffolds often contain discrete ...
Lyu, Siwen Yang, Qi Duan, Xuehui Liu, Xuanting Du, Zhiyang Shang, Xiaomin Xu, Menglei Liu, Jingbo Pan, Fengguang Zhang, Ting
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Published in
Frontiers in Nutrition
Introduction Fermented egg-milk peptides (FEMPs) could enhance the colon-intestinal barrier and upgrade the expression of zonula occludens-1 and mucin 2. Besides, the underlying biological mechanism and the targets FEMPs could regulate were analyzed in our study. Methods Herein, the immunofluorescence technique and western blot were utilized to eva...