Cabri, Walter Cantelmi, Paolo Corbisiero, Dario Fantoni, Tommaso Ferrazzano, Lucia Martelli, Giulia Mattellone, Alexia Tolomelli, Alessandra
Published in
Frontiers in Molecular Biosciences
Targeting protein-protein interactions (PPIs) has been recently recognized as an emerging therapeutic approach for several diseases. Up today, more than half a million PPI dysregulations have been found to be involved in pathological events. The dynamic nature of these processes and the involvement of large protein surfaces discouraged anyway the s...
Silva, G M Berto, D H Lima, C A Waitman, K B Lima, C F G Prezoto, B C Vieira, M L Rocha, M M T Gonçalves, L R C Andrade, S A
...
Published in
Toxicon : official journal of the International Society on Toxinology
Snakebite accidents are a public health problem that affects the whole world, causing thousands of deaths and amputations each year. In Brazil, snakebite envenomations are caused mostly by snakes from the Bothrops genus. The local symptoms are characterized by pain, swelling, ecchymosis, and hemorrhages. Systemic disturbances can lead to necrosis a...
přívratský, jan
Pro potřeby charakterizace neribozomálních peptidů z hmotnostních spekter vznikla nová aplikace MassSpecBlocks - webová open-source aplikace vycházející z aplikace "Building Blocks Database Generator of Natural Compounds" (Bbdgnc) s možností vyhledávání chemických struktur ve veřejných databázích jako PubChem, ChemSpider, ChEBI a Norine. Struktury ...
Chen, Jing Jiang, Yang Chang, Tse-Shao Joshi, Bishnu Zhou, Juan Rubenstein, Joel H Wamsteker, Erik J Kwon, Richard S Appelman, Henry Beer, David G
...
Published in
Gut
Zhang, Shuai Chen, Jiajun Liu, Jianli Pyles, Harley Baker, David Chen, Chun-Long De Yoreo, James J
Published in
Advanced materials (Deerfield Beach, Fla.)
Biomolecular self-assembly is a key process used by life to build functional materials from the "bottom up." In the last few decades, bioengineering and bionanotechnology have borrowed this strategy to design and synthesize numerous biomolecular and hybrid materials with diverse architectures and properties. However, engineering biomolecular self-a...
Wilhelm, Maud Kaur, Amandeep Wernli, Marion Hirsch, Hans H
Published in
The Journal of infectious diseases
BK polyomavirus (BKPyV) remains a significant cause of premature kidney transplant failure. In the absence of effective antivirals, current treatments rely on reducing immunosuppression to regain immune control over BKPyV replication. Increasing BKPyV-specific CD8 T cells correlate with clearance of BKPyV DNAemia in kidney transplant patients. We c...
Ferguson Johns, Hannah P Harrison, Emily E Stingley, Kyla J Waters, Marcey L
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
Selective molecular recognition of hydrophilic guests in water plays a fundamental role in a vast number of biological processes, but synthetic mimicry of biomolecular recognition in water still proves challenging both in terms of achieving comparable affinities and selectivities. This Review highlights strategies that have been developed in the fi...
Martinšek, Klemen
Monoklonska protitelesa omogočajo specifično vezavo antigena, zaradi česar jih uporabljamo v širokem naboru aplikacij. Monoklonska protitelesa praviloma izoliramo in prečistimo z afinitetno kromatografijo na osnovi proteina A, ki ima kljub visoki selektivnosti vezave številne pomanjkljivosti. Zaradi tega razvijajo alternativne ligande, ki so stabil...
Baruch-Leshem, Avigail Chevallard, Corinne Gobeaux, Frédéric Guenoun, Patrick Daillant, Jean Fontaine, Philippe Goldmann, Michel Kushmaro, Ariel Rapaport, Hanna
Amphiphilic peptides that induce catalysis are interesting alternatives to natural enzymes thanks to robustness of their synthesis and the ability to induce certain types of conformations by specific motifs of amino acid sequences. Various studies aimed at mimicking the activity of serine proteases by designed peptides. Here we demonstrate that the...
Stincic, Todd L Rønnekleiv, Oline K Kelly, Martin J
Published in
Steroids
Reproduction and energy balance are inextricably linked in order to optimize the evolutionary fitness of an organism. With insufficient or excessive energy stores a female is liable to suffer complications during pregnancy and produce unhealthy or obesity-prone offspring. The quintessential function of the hypothalamus is to act as a bridge between...
