Li, Hongxin Zhao, Wen Chang, Caiyun Xuan, Tiantian Wang, Chengjun Zhang, Rongyu Yang, Chuang Wang, Jian Yi, Cuihua Wang, Xiuwen
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Published in
Frontiers in Pharmacology
Background Aumolertinib demonstrated superior progression-free survival (PFS) and a well-tolerated toxicity profile compared to gefitinib in front-line treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) in the AENEAS trial. However, patient-reported outcomes (PROs) of aumolertinib have not been published. Methods In this...
Sorah, Jonathan D Deal, Allison M Stein, Sophia I Jonsson, Mattias Innocenti, Federico Turk, Anita Boles, Jeremiah C Irvin, William Basch, Ethan M Sanoff, Hanna K
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Published in
The oncologist
Standard investigator-based adverse events (AE) assessment is via CTCAE for clinical trials. However, including the patient perspective through PRO (patient-reported outcomes) enhances clinicians' understanding of patient toxicity and fosters early detection of AEs. We assessed longitudinal integration of PRO-CTCAE within clinical workflow in a pha...
Sperl, Lisa Stamm, Tanja Mosor, Erika Ritschl, Valentin Sivan, Manoj Hoffmann, Kathryn Gantschnig, Brigitte
Published in
Frontiers in Medicine
Background Experts estimate that in up to 10% of the infected, SARS-CoV-2 would cause persistent symptoms, activity limitations and reduced quality of life. Referred to as long COVID, these conditions might, in the future, specifically impact German-speaking countries due to their higher rates of unvaccinated people compared to other Western countr...
Verma, Subodh Butler, Javed Borlaug, Barry A Davies, Melanie J Kitzman, Dalane W Petrie, Mark C Shah, Sanjiv J Jensen, Thomas Jon Rasmussen, Søren Rönnbäck, Cecilia
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Published in
Journal of the American College of Cardiology
Obesity is a key factor in the development and progression of both heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF). In the STEP-HFpEF Program (comprising the STEP-HFpEF [Research Study to Investigate How Well Semaglutide Works in People Living With Heart Failure and Obesity] and STEP-HFpEF DM [Research Study to L...
Sherrod, Charles F 4th Saberi, Sara Nassif, Michael E Claggett, Brian L Coats, Caroline J Garcia-Pavia, Pablo Januzzi, James L Lewis, Gregory D Ma, Changsheng Maron, Martin S
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Published in
Journal of the American College of Cardiology
A primary goal in treating obstructive hypertrophic cardiomyopathy (oHCM) is to improve patients' health status: their symptoms, function, and quality of life. The health status benefits of aficamten, a novel cardiac myosin inhibitor, have not been comprehensively described. This study sought to determine the effect of aficamten on patient-reported...
del Olmo Rodríguez, Marta Martos Martinez, Rafael Pascual Martínez, Adriana Miranda Castillo, Carolina Short Apellaniz, Jorge Pfang, Bernadette Baca-García, Enrique Córdoba Mascuñano, Raúl
Published in
Frontiers in Public Health
Background The spreading adoption of value-based models of healthcare delivery has incentivized the use of patient-reported outcomes and experience measures (PROMs and PREMs) in clinical practice, with the potential to enrich the decision-making process with patient-reported data. Methods This perspective article explores PROs and the shared decisi...
Rosenkranz, Bernd
Published in
Frontiers in Pharmacology
Liu, Lei Xiang, Yuqing Xiong, Lujing Li, Chao Dai, Wei Hu, Jinchuan Shui, Chunyan Zhou, Yuqiu Wang, Xu Ma, Linjie
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Published in
Frontiers in Psychology
Introduction To evaluate the preoperative health-related quality of life (HRQoL) and influencing factors of HRQoL in patients undergoing thyroidectomy based on patient-reported outcomes. Materials and methods Patients who were diagnosed and treated in Sichuan Cancer Hospital from February 2022 to December 2022 and were scheduled to undergo thyroide...
Baker, Arabella
Background Eczema is a chronic, inflammatory, itchy skin condition affecting 15-30% children and 2-10% adults. In randomised controlled trials (RCTs), patient-reported outcome measures (PROMs) are often used to evaluate interventions. The Harmonising Outcome Measures for Eczema (HOME) initiative developed a core outcome set (COS) consisting of four...
Borriello, Giovanna Chisari, Clara Grazia Maimone, Davide Mirabella, Massimiliano Paolicelli, Damiano Assogna, Francesco Caradonna, Sandro Patti, Francesco
Published in
Frontiers in Neurology
Patient-reported outcomes (PROs) are essential for understanding the effects of MS and its treatments on patients’ lives; they play an important role in multiple sclerosis (MS) research and practice. We present the protocol for an observational study to prospectively assess the effect of cladribine tablets on PROs and their correlation to disabilit...
