Liu, Mingyue Xu, Chang Qin, Xiaochun Liu, Wenwu Li, Deping Jia, Hui Gao, Xudong Wu, Yuting Wu, Qiong Xu, Xiangbo
...
Published in
Frontiers in Oncology
Multidrug resistance (MDR) is considered as a primary hindrance for paclitaxel failure in non-small cell lung cancer (NSCLC) patients, in which P-glycoprotein (P-gp) is overexpressed and the PI3K/Akt signaling pathway is dysregulated. Previously, we designed and synthesized DHW-221, a dual PI3K/mTOR inhibitor, which exerts a remarkable antitumor po...
Fofana, Souleymane Delporte, Cédric Calvo Esposito, Rafaèle Ouédraogo, Moussa Van Antwerpen, Pierre Guissou, Innocent Pierre Semdé, Rasmané Mathieu, Véronique
Published in
Molecules (Basel, Switzerland)
Although Erythrina senegalensis is a plant widely used in traditional medicine in sub-Saharan Africa, its biological properties have been poorly investigated to date. We first characterized by conventional reactions the composition of several stem bark extracts and evaluated in acellular and cellular assays their pro- or antioxidant properties supp...
lee;, hong-jae
PSMD14, a subunit of the 19S regulatory particles of the 26S proteasome, was recently identified as a potential prognostic marker and therapeutic target in diverse human cancers. Here, we show that the silencing and pharmacological blockade of PSMD14 in MDA-MB 435S breast cancer cells induce paraptosis, a non-apoptotic cell death mode characterized...
pyrczak-felczykowska;, agnieszka
Derivatives of usnic acid (UA), a secondary metabolite from lichens, were synthesized to improve its anticancer activity and selectivity. Recently we reported the synthesis and activity of an UA isoxazole derivative, named 2b, against cancer cells of different origins. Herein, the molecular mechanisms underlying its activity and efficacy in vivo we...
linh, phuong
Chemotherapy has been a standard intervention for a variety of cancers to impede tumor growth, mainly by inducing apoptosis. However, development of resistance to this regimen has led to a growing interest and demand for drugs targeting alternative cell death modes, such as paraptosis. Here, we designed and synthesized a novel derivative of a pyraz...
fares;, mona
Tetracycline-3 (4-dedimethylamino sancycline, COL-3) is a non-antibiotic tetracycline derivative. COL-3 exerts potent anti-metalloproteinase activity and its antitumor effects have been reported both in vitro and in vivo. In this study, we investigated the mechanisms of COL-3-induced cytotoxicity in a chronic myeloid leukemia cell line, K562, chara...
Samuelsen, Lisa Hansen, Poul Erik Vang, Ole
Published in
Natural product research
Usnic acid has anti-cancer activity, however, low solubility and toxicity limit the potential. To investigate biological activity of usnic acid derivatives, enantiopure derivatives were synthesised by reacting usnic acid with ethylenediamine, which yielded one dimer product ((+)-1), and two tetra cyclic compounds ((+)-2 and (-)-2). The products wer...
Balachandran, Chandrasekar Yokoi, Kenta Naito, Kana Haribabu, Jebiti Tamura, Yuichi Umezawa, Masakazu Tsuchiya, Koji Yoshihara, Toshitada Tobita, Seiji Aoki, Shin
...
Published in
Molecules (Basel, Switzerland)
In our previous paper, we reported that amphiphilic Ir complex-peptide hybrids (IPHs) containing basic peptides such as KK(K)GG (K: lysine, G: glycine) (e.g., ASb-2) exhibited potent anticancer activity against Jurkat cells, with the dead cells showing a strong green emission. Our initial mechanistic studies of this cell death suggest that IPHs wou...
Wang, Shuai Guo, Yazhou Yang, Chen Huang, Ruijie Wen, Yuting Zhang, Chunyan Wu, Chenchen Zhao, Baoyu
Published in
Frontiers in Pharmacology
Swainsonine (SW), an indolizidine alkaloid extracted from locoweeds, was shown toxic effects in multiple studies, but the underlying action mechanism remains unclear. SW is known to cause autophagy and apoptosis, but there has been no report on paraptosis mediated cell death. Here, we showed that SW induced rat primary renal tubular epithelial cell...
Dai, Chun-Hau Zhu, Li-Rong Wang, Yi Tang, Xing-Ping Du, Yong-Jie Chen, Yong-Chang Li, Jian
Published in
Journal of cellular physiology
Non-small cell lung cancer (NSCLC) with wild-type epidermal growth factor receptor (EGFR) is intrinsic resistance to EGFR-tyrosine kinase inhibitors (TKIs), such as afatinib. Celastrol, a natural compound with antitumor activity, was reported to induce paraptosis in cancer cells. In this study, intrinsic EGFR-TKI-resistant NSCLC cell lines H23 (EGF...
