• Mg-ACP/PAA hybrid nanoparticles have been synthesized following a biomineralization strategy. • The chelation of PAA molecules in synergy with Mg2+ substitution improves thermal stability of Mg-ACP/PAA nanoparticles. • The Mg-ACP/PAA nanoparticles are pH sensitive and can be digested in cell lysosomes within 24 h.
Journal of colloid and interface science
A prospective class of materials for drug delivery is lyotropic liquid crystalline (LLC) nanoparticles, such as cubosomes and hexosomes. Efforts are being made to generate a pH dependent system, which exhibits slow release hexosomes (H2) at physiological pH and relatively fast release cubosomes (Q2) at acidic disease sites such as in various cancer...
Drug Design, Development and Therapy
Purpose Prodrug technology-based combination drug therapy has been exploited as a promising treatment strategy to achieve synergistic lung cancer therapy, reduce drug dose, and decrease side effects. In the present study, we synthesized a pH and glutathione (GSH) sensitive prodrug, cisplatin (CIS) and doxorubicin (DOX) conjugates (CIS-DOXp). CIS-DO...
This study reports the generation of novel, aqueous-dispersible plunoric-CD nanoconjugates encapsulating doxorubicin (Dox). The fluorescent CD were conjugated with plunoric F127 to form biocompatible delivery matrix and were further loaded with fluorescent Dox molecule. The resulting particles were analyzed for multiplexed bioimaging and targeted d...
• PH-responsive self-assembling films were used to intelligently release the drugs at atherosclerotic lesions. • As a gaseous signaling molecule, H2S donor ACS14 was loaded into the films used in the field of cardiovascular disease treatment. • H2S can help to regulate vascular remodeling and balance the vascular function.
16 Nanostructured (hybrid) membranes combining properties of inorganic and polymeric materials is an 17 integral part of the field of separation technology. Mixed matrix membranes were prepared from 18 oppositely charged inorganic (INPs) and polymeric (PNPs) nanoparticles using spin coating method. Four 19 different types of PNPs were prepared. Pol...
Microfluidics and Nanofluidics
Mint oil is a complex mixture of comparatively volatile and labile components, making it challenging to be efficiently encapsulated and retained in microcapsules using traditional approaches. Microencapsulation, by encapsulating the substance with certain shells, can effectively reduce the diffusion, evaporation and the reactions of the inside acti...
Journal of Polymer Research
A series of amphiphilic four-arm star polymers poly(e-caprolactone)-b-poly(2-(diethylamino)ethylmethacrylate) (4AS-PCL-b-PDMAEMA) were developed by a combination of ring opening polymerization (ROP) and continuous activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP). The molecular structures of the copolymer...
Angewandte Chemie (International ed. in English)
In situ, reversible coacervate formation within lipid vesicles represents a key step in the development of responsive synthetic cellular models. Herein, we exploit the pH responsiveness of a polycation above and below its pKa , to drive liquid-liquid phase separation, to form single coacervate droplets within lipid vesicles. The process is complete...