Published in Journal of pediatric urology
The plethora of scientific data and explosion of published materials often leave it challenging to develop a clear and concise overview of many scientific topics. A number of factors may contribute to our misunderstanding. It is the focus of this article to describe primary reasons for failure to establish a clear, factual and functional understand...
Concerns have been expressed over standards of statistical interpretation. Results with p0.05. Referring to strengths of association in “study participants” gives them gravitas, which may help to avoid this. This contrasts with the common practice of focusing on imprecision, by referring to the “sample” and to “point estimates”. Unlike formal stati...
Published in F1000Research
The ccbmlib Python package is a collection of modules for modeling similarity value distributions based on Tanimoto coefficients for fingerprints available in RDKit. It can be used to assess the statistical significance of Tanimoto coefficients and evaluate how molecular similarity is reflected when different fingerprint representations are used. S...
Published in Academic radiology
The purpose of this study was to validate a Bayesian statistical model of item response theory (IRT). IRT was used to evaluate a new modality (temporal subtraction, TS) in observer studies of radiologists, compared with a conventional modality (computed tomography). From previously published papers, we obtained two datasets of clinical observer stu...
Published in Frontiers in psychology
Turmoil has engulfed psychological science. Causes and consequences of the reproducibility crisis are in dispute. With the hope of addressing some of its aspects, Bayesian methods are gaining increasing attention in psychological science. Some of their advantages, as opposed to the frequentist framework, are the ability to describe parameters in pr...
Published in Biology Bulletin
AbstractIn 2017, a group of the leading mathematical statisticians published a paper-manifesto having an extremely simple sense: the common critical level of p-values should be decreased by an order of magnitude (0.005 instead of 0.05) (Benjamin, et al., 2017). In this review, the arguments of proponents and opponents of this proposal are discussed...
Cet article concerne la modélisation de données incertaines à partir de mesures répétées mais non-reproductibles. Différentes approches issues des théories modernes de l'incertain sont considérées. Plus précisément, l'article s'intéresse à diverses extensions de tests statistiques non-paramétriques aux données incertaines. Dans ce travail prélimina...
Software packages usually report the results of statistical tests using p-values. Users often interpret these by comparing them to standard thresholds, e.g. 0.1%, 1% and 5%, which is sometimes reinforced by a star rating (***, **, *). We consider an arbitrary statistical test whose p-value p is not available explicitly, but can be approximated by M...
Published in Journal of Translational Medicine
BackgroundSWATH-MS has emerged as the strategy of choice for biomarker discovery due to the proteome coverage achieved in acquisition and provision to re-interrogate the data. However, in quantitative analysis using SWATH, each sample from the comparison group is run individually in mass spectrometer and the resulting inter-run variation may influe...
Multiple tests arise frequently in epidemiologic research. However, the issue of multiplicity adjustment is surrounded by confusion and controversy, and there is no uniform agreement on whether or when adjustment is warranted. In this paper we compare frequentist and Bayesian frameworks for multiple testing. We argue that the frequentist framework ...
