Chu, Jun Liu, Chen-Xu Song, Rui Li, Qing-Lin
Published in
Neural regeneration research
Ferroptosis is a type of programmed cell death dependent on iron. It is different from other forms of cell death such as apoptosis, classic necrosis and autophagy. Ferroptosis is involved in many neurodegenerative diseases. The role of ferroptosis in glutamate-induced neuronal toxicity is not fully understood. To test its toxicity, glutamate (1.25-...
Alayash, Abdu I
Published in
Shock (Augusta, Ga.)
Several adverse events have been associated with the infusion of hemoglobin-based oxygen carriers (HBOCs), including transient hypertension, gastrointestinal, pancreatic/liver enzyme elevation, and cardiac/renal injury in humans. Although several mechanisms have been suggested, the basis of HBOC toxicity is still poorly understood. Scavenging of va...
Wang, Quan Zhang, Ruirui You, Guoxing Hu, Jilin Li, Penglong Wang, Ying Zhang, Jun Wu, Yan Zhao, Lian Zhou, Hong
...
Oxidative toxicity has impeded the development of haemoglobin-based oxygen carriers (HBOCs) by causing methaemoglobin (MetHb) formation and inducing oxidative stress. In our previous work, polydopamine-coated haemoglobin (Hb-PDA) nanoparticles have been designed and synthesized with the capacity to reduce oxidative toxicity. In this investigation, ...
Wang, Quan Zhang, Ruirui You, Guoxing Hu, Jilin Li, Penglong Wang, Ying Zhang, Jun Wu, Yan Zhao, Lian Zhou, Hong
...
Oxidative toxicity has impeded the development of haemoglobin-based oxygen carriers (HBOCs) by causing methaemoglobin (MetHb) formation and inducing oxidative stress. In our previous work, polydopamine-coated haemoglobin (Hb-PDA) nanoparticles have been designed and synthesized with the capacity to reduce oxidative toxicity. In this investigation, ...
Wang, Dan Wang, Jibiao Wang, Dujun Yu, Xiaofeng Olatunji, Opeyemi Joshua Ouyang, Zhen Wei, Yuan
Published in
Chemistry & biodiversity
The current study was aimed at investigating the neuroprotective effects of the butanol fraction from Cordyceps cicadae (CBU ), which was responsible for the anti-aging effect of this medicine. Glutamate-induced PC12 cells were used as a model to determine the neuroprotective effect against oxidative cell death. Cell viability, cytotoxicity, flow c...
Han, S Zhao, B Pan, X Song, Z Liu, J Gong, Y Wang, M
Published in
Neuroscience
It is well known that estrogen exerts neuroprotective effect against various neuronal damages. However, the estrogen receptor (ER) that mediates estrogen neuroprotection has not been well established. In this study, we investigated the potential receptor that mediates estrogen neuroprotection and the underlying molecular mechanisms. Hydrogen peroxi...