Kandpal, Meenakshi Indari, Omkar Baral, Budhadev Jakhmola, Shweta Tiwari, Deeksha Bhandari, Vasundhra Pandey, Rajan Kumar Bala, Kiran Sonawane, Avinash Jha, Hem Chandra
...
Published in
Metabolites
The gut-brain axis is a bidirectional communication network connecting the gastrointestinal tract and central nervous system. The axis keeps track of gastrointestinal activities and integrates them to connect gut health to higher cognitive parts of the brain. Disruption in this connection may facilitate various neurological and gastrointestinal pro...
wang, shuting yanlai, ji ren, mingxue jun, li yang, zuyao
The incidence of prostate, breast, and thyroid cancers has increased in China over the past few decades. Whether and how much these increases can be attributed to overdiagnosis are less understood. This study aimed to estimate the proportion of overdiagnosis among these three cancers in China during 2004–2019. The age-specific cancer incidence, can...
cirillo, nicola
Early detection of cancer is considered a cornerstone of preventive medicine and is widely perceived as the gateway to reducing cancer deaths. Based on this assumption, large trials are currently underway to evaluate the accuracy of early detection tests. It is imperative, therefore, to set meaningful “success criteria” in early detection that refl...
Chatzigeorgiou, Charikleia Barrett, Jennifer H Martin, Javier Morgan, Ann W Mackie, Sarah L
Published in
Rheumatology (Oxford, England)
GCA can be confirmed by temporal artery biopsy (TAB) but false negatives can occur. GCA may be overdiagnosed in TAB-negative cases, or if neither TAB nor imaging is done. We used HLA genetic association of TAB-positive GCA as an 'unbiased umpire' test to estimate historic overdiagnosis of GCA. Patients diagnosed with GCA between 1990 and 2014 were ...
Boshnjaku, Arben Krasniqi, Ermira
Published in
Frontiers in Medicine
jiun-yan, wu shyu, yuh-kae lee, yu-kwang wang, yu-chiao chiang, chun-ju you, san-lin liao, li-jen hsu, wan-lun chen, yong-chen
Background: Thyroid cancer incidence has increased globally in recent decades, especially in females, although its trends in Taiwan have not been studied extensively. This study aimed to investigate changes in female incidence and possible causes of thyroid cancer in Taiwan. Methods: Using the Taiwan Cancer Registry (TCR) Database, age-standardized...
Chaloupka, Michael Pyrgidis, Nikolaos Ebner, Benedikt Volz, Yannic Pfitzinger, Paulo L Berg, Elena Enzinger, Benazir Atzler, Michael Ivanova, Troya Clevert, Dirk-André
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Published in
BJU international
To assess the added value of concurrent systematic randomised ultrasonography-guided biopsy (SBx) to multiparametric magnetic resonance imaging (mpMRI)-targeted biopsy and the additional rate of overdiagnosis of clinically insignificant prostate cancer (ciPCa) by SBx in a large contemporary, real-world cohort. A total of 1552 patients with positive...
sudarikov, andrey
Overdiagnosis, associated with mass testing in healthy populations, is a significant issue for breast, prostate, renal, and thyroid cancers. During the lockdowns caused by the COVID-19 pandemic, the intensity of cancer screening was expected to go down. In this study, we analyzed the impact of the expected reduction in screening intensity on morbid...
cirillo, nicola
Despite the profession placing great emphasis on oral potentially malignant disorders (OPMDs) as a gateway for early recognition and consequently better outcomes for oral cancer, the death rates for lip and oral cavity cancer have remained stagnant for three decades. Evidence shows that only a small fraction of oral cancers are in fact preceded by ...
De la Parra, Irene Gómez Rivas, Juan Gutiérrez, Beatriz Marugán, María Jesús Enikeev, Dmitry Somani, Bhaskar K. Barrera, Jerónimo Moreno-Sierra, Jesús
Published in
Frontiers in Urology
Since overdiagnosis and overtreatment pose significant risks in managing prostate cancer (PCa), active surveillance (AS) is the most common treatment in low-risk patients. However, there is no general agreement yet on the inclusion criteria and the required follow-up. Multiparametric magnetic resonance imaging (mpMRI) of the prostate was born as a ...
