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The neutral red assay can be used to evaluate cell viability during autophagy or in an acidic microenvironment in vitro....

Published in Biotechnic & histochemistry : official publication of the Biological Stain Commission

Harsh conditions within the tumor microenvironment, such as hypoxia and extracellular acidic pH (pHe), inactivate some chemotherapies, which results in limited or no cytotoxicity. Standard MTT, ATPlite and protease assays that are used to determine the potency of newly developed drugs often give erroneous results when applied under hypoxic or acidi...

NEPA as antiemetic prophylaxis after failure of 5HT3-RA plus dexamethasone in patients receiving carboplatin and gemcita...

Published in Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Chemotherapy-induced nausea and vomiting (CINV) may affect adherence to planned chemotherapy treatments and compromise patients' quality of life during the therapy. NEPA is an oral fixed combination of netupitant, a highly-selective NK1-RA and palonosetron, a 5HT3-RA, approved for the prevention of acute and delayed CINV. The aim of this study was ...

[How I do … ex vivo in vitro maturation?]

Published in Gynecologie, obstetrique, fertilite & senologie

Fertility preservation in rare ovarian tumors.

Published in International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Although gynecologic cancers usually affect older women, a significant proportion of patients with rare ovarian tumors are of reproductive age. In a young patient who presents with a pelvic mass, a primary consideration should be the probability of a malignancy. If there is any suspicion of a cancer diagnosis, the patient should be referred to a gy...

Adherence and adverse events of intraperitoneal chemotherapy in optimally debulked ovarian cancer patients: Real-life st...

Published in Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Intraperitoneal with intravenous chemotherapy (IP/IV) is the recommended option for patients with stage III cancer with optimally debulked (

Feasibility of in vitro maturation of oocytes collected from patients with malignant ovarian tumors undergoing fertility...

Published in International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

In vitro maturation of oocytes collected from oophorectomy samples might be a promising approach in the field of oncofertility. In this study, we evaluate the feasibility of in vitro maturation of oocytes collected from oophorectomy samples in patients with ovarian tumors. This prospective observational study included 27 patients with malignant ova...

Oncologic outcomes of uterine preservation for pre-menopausal patients with stage II epithelial ovarian carcinoma.

Published in International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Fertility-sparing surgery is rarely offered for patients with stage II epithelial ovarian carcinoma. The aim of the present study was to evaluate the overall survival of pre-menopausal patients with stage II epithelial ovarian carcinoma who did not undergo hysterectomy. The National Cancer Database was accessed, and patients aged ≤40 years without ...

EZH2-miRNA Positive Feedback Promotes Tumor Growth in Ovarian Cancer

Published in Frontiers in Oncology

Enhancer of zester homolog 2 (EZH2), a histone methyl transferase that mediates H3K27me3 through polycomb repressive complex 2 (PRC2), is overexpressed in ovarian cancer and promotes malignant proliferation. However, the underlying mechanism of maintaining high EZH2 expression remains elusive. Here we showed that microRNA(miRNA) inhibited EZH2 by b...