Avanzi, Mauro P Yeku, Oladapo Li, Xinghuo Wijewarnasuriya, Dinali P van Leeuwen, Dayenne G Cheung, Kenneth Park, Hyebin Purdon, Terence J Daniyan, Anthony F Spitzer, Matthew H
...
Published in
Cell reports
Chimeric antigen receptor (CAR) T cell therapy has proven clinically beneficial against B cell acute lymphoblastic leukemia and non-Hodgkin's lymphoma. However, suboptimal clinical outcomes have been associated with decreased expansion and persistence of adoptively transferred CAR T cells, antigen-negative relapses, and impairment by an immunosuppr...
Zalewski, Kamil Benke, Malgorzata Mirocha, Bartlomiej Radziszewski, Jakub Chechlinska, Magdalena Kowalewska, Magdalena
Published in
Current pharmaceutical design
Technetium (99mTc)-radiolabeled colloids are popular tracers used to map lymphatic vessels and regional lymph nodes (LNs). The regional LN status is a significant determinant of cancer stage and patient prognosis, and strongly influences treatment. Regional LN dissection has become part of surgical treatment. However, not all patients with LN invol...
Hung, Chien-Fu Xu, Xuequn Li, Linhong Ma, Ying Jin, Qiu Viley, Angelia Allen, Cornell Natarajan, Pachai Shivakumar, Rama Peshwa, Madhusudan V
...
Published in
Human gene therapy
CD19-targeted chimeric antigen receptor (CAR) engineered T/natural killer (NK)-cell therapies can result in durable clinical responses in B-cell malignancies. However, CAR-based immunotherapies have been much less successful in solid cancers, in part due to "on-target off-tumor" toxicity related to expression of target tumor antigens on normal tiss...
Pharoah, Paul David
Genotype data and related phenotype data for Ovarian Cancer Association Consortium project investigating common variantion in GTPAse genes and ovarian cancer risk
Chen, Shipeng Yang, Luo Feng, Jie
Published in
The Journal of pharmacy and pharmacology
Our study showed that NC induced apoptosis in SKOV3 cells by activating the Fas signalling pathway, and caspase-8 played an important role in this process.
Canlorbe, Geoffroy Touboul, Cyril Chargari, Cyrus Bentivegna, Enrica Maulard, Amandine Pautier, Patricia Genestie, Catherine Morice, Philippe Gouy, Sébastien
Published in
Anticancer research
An ileostomy at the time of complete CRS negatively affects survival in patients with advanced-stage ovarian cancer.
Liu, Siwei Lei, Huajiang Luo, Fangyuan Li, Yilin Xie, Lan
Published in
Biological Chemistry
This study aimed at investigating the biological functions of long non-coding RNAs (lncRNAs) hox transcript antisense intergenic RNA (HOTAIR) in resistant ovarian cancer cells, exploring the regulation effect of HOTAIR on HOXA7, and investigating their influence on the chemosensitivity of ovarian cancer cells. Quantitative real-time polymerase chai...
Stefan, Niţu Teodor Silvia, Savin Ovidiu, Costea Daniel Vasile, Sârbu Silvia, Şerban Irina, Niţu
Published in
ARS Medica Tomitana
Ovarian cancer is perhaps the most “worst” pathology in women’s genital area and represents the greatest diagnostic challenge and surgical treatment of genital cancers, and as much as the disease has a onset and asymptomatic evolution to the advanced stages or with a confused symptom. The present study was performed due to the following factors cha...
Birkbak, N. J. Li, Y. Pathania, S Greene-Colozzi, A Dreze, M Bowman-Colin, C Sztupinszki, Z. Krzystanek, M. Diossy, Miklos Tung, N
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Platinum based therapy is an effective treatment for a subset of triple negative breast cancer and ovarian cancer patients. In order to increase response rate and decrease unnecessary use, robust biomarkers that predict response to therapy are needed. We performed an integrated genomic approach combining differential analysis of gene expression and...
Muthukrishnan, Uma
Histones are chromatin-associated proteins localized to the nucleus. However, extracellular histones are present in biofluids from healthy individuals and become elevated under disease conditions, such as neurodegeneration and cancer. Hence, extracellular histones may have important biological functions in healthy and diseased states, which are not...
