Public health surveillance systems and outbreak response: evidence from the field
Published in Frontiers in Tropical Diseases
Public health surveillance systems and outbreak response: evidence from the field
Enabling countries to manage outbreaks: statistical, operational, and contextual analysis of the early warning and respo...
Published in Frontiers in Public Health
Introduction Dengue is currently the fastest-spreading mosquito-borne viral illness in the world, with over half of the world's population living in areas at risk of dengue. As dengue continues to spread and become more of a health burden, it is essential to have tools that can predict when and where outbreaks might occur to better prepare vector c...
Accelerated and intensified manufacturing of an adenovirus-vectored vaccine to enable rapid outbreak response.
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Published in Biotechnology and bioengineering
The Coalition for Epidemic Preparedness Innovations' "100-day moonshot" aspires to launch a new vaccine within 100 days of pathogen identification, followed by large-scale vaccine availability within the "second hundred days." Here, we describe work to optimize adenoviral vector manufacturing for rapid response, by minimizing time to clinical trial...
Task Force for a rapid response to an outbreak of severe acute hepatitis of unknown aetiology in children in Portugal in...
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Published in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
On 5 April 2022, the United Kingdom reported an increase of cases of severe acute hepatitis of unknown aetiology in children, several needing hospitalisation and some required liver transplant or died. Thereafter, 35 countries reported probable cases, almost half of them in Europe. Facing the alert, on 28 April, Portugal created a multidisciplinary...
Regional Evaluation of Two SARS-CoV-2 Antigen Rapid Diagnostic Tests in East Africa
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Published in Microbiology Spectrum
The clinical performance of two rapid antigen tests for the diagnosis of Severe Acute Respiratory Coronavirus (SARS-CoV-2) were regionally evaluated in East African populations. Swabs were collected from 1,432 individuals from five Partner States of the East African Community (Tanzania, Uganda, Burundi, Rwanda and South Sudan). The two rapid antige...
Development of an Accessible and Scalable Quantitative Polymerase Chain Reaction Assay for Monkeypox Virus Detection.
Published in The Journal of infectious diseases
During the 2022 monkeypox (MPX) outbreak, testing has been limited and results delayed, allowing ongoing transmission. Gold-standard quantitative polymerase chain reaction (qPCR) diagnostics are difficult to obtain. This research adapted the June 2022 CDC MPX qPCR assay for broad implementation. Validated using MPX stocks in a matrix with multiple ...
Serial Interval and Incubation Period Estimates of Monkeypox Virus Infection in 12 Jurisdictions, United States, May–Aug...
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Published in Emerging Infectious Diseases
Using data from 12 US health departments, we estimated mean serial interval for monkeypox virus infection to be 8.5 (95% credible interval 7.3–9.9) days for symptom onset, based on 57 case pairs. Mean estimated incubation period was 5.6 (95% credible interval 4.3–7.8) days for symptom onset, based on 35 case pairs.
Laboratory Evaluation and Field Testing of Dengue NS1 and IgM/IgG Rapid Diagnostic Tests in an Epidemic Context in Seneg...
In Senegal, the burden of dengue is increasing and expanding. As case management and traditional diagnostic techniques can be difficult to implement, rapid diagnostic tests (RDTs) deployed at point of care are ideal for investigating active outbreaks. The aim of this study was to evaluate the diagnostic performance of the Dengue NS1 and Dengue IgM/...
Looking back at prospective modeling of outbreak response strategies for managing global type 2 oral poliovirus vaccine ...
Published in Frontiers in Public Health
Introduction Detection of poliovirus transmission and ongoing oral poliovirus vaccine (OPV) use continue to delay poliomyelitis eradication. In 2016, the Global Polio Eradication Initiative (GPEI) coordinated global cessation of type 2 OPV (OPV2) for preventive immunization and limited its use to emergency outbreak response. In 2019, GPEI partners ...
Communicating risk during early phases of COVID-19: Comparing governing structures for emergency risk communication acro...
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Published in Frontiers in Public Health
Background Emergency risk communication (ERC) is key to achieving compliance with public health measures during pandemics. Yet, the factors that facilitated ERC during COVID-19 have not been analyzed. We compare ERC in the early stages of the pandemic across four socio-economic settings to identify how risk communication can be improved in public h...
