Cappelle, Sylvie Moreaux, Michel Karmali, R. Iconaru, L. Baleanu, F. Kinnard, V. Paesmans, Marianne Rozenberg, S. Rubinstein, M. Surquin, M.
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Areal bone mineral density (aBMD) has a low sensitivity to identify women at high fracture risk. The FRAX algorithm, by combining several clinical risk factors, might improve fracture prediction compared to aBMD alone. Several micro-architectural and biomechanical parameters which can be measured by high-resolution peripheral quantitative computed ...
You, Murong Zhang, Liang Zhang, Xiaoxiang Fu, Yang Dong, Xieping
Published in
Clinical Interventions in Aging
Background Studies have shown that microRNA (miRNA) regulates gene expression of osteoporosis (OS). It is known that miR-197-3p is abnormally expressed in osteoporosis. This study is to investigate the mechanism of miR-197-3p in regulating osteoblast differentiation. Methods Rats were ovariectomized to establish an animal model of postmenopausal os...
Li, Xuedong Lin, Xixi Wu, Zuoxing Su, Yuangang Liang, Jiamin Chen, Runfeng Yang, Xue Hou, Lei Zhao, Jinmin Liu, Qian
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Published in
Drug Design, Development and Therapy
Introduction Osteoporosis is an osteolytic bone condition characterized by decreased bone strength and increased bone fragility. It is the result of elevated formation or activity of bone-resorbing osteoclasts. Although current therapeutic agents are efficacious against osteoclast-mediated bone loss, detrimental side effects preclude the long-term ...
Babel, Hugo Omoumi, Patrick Cosendey, Killian Cadas, Hugues Jolles, Brigitte M. Favre, Julien
Published in
Journal of Clinical Medicine
While alterations in bone mineral density (BMD) are of interest in a number of musculoskeletal conditions affecting the knee, their analysis is limited by a lack of tools able to take full advantage of modern imaging modalities. This study introduced a new method, combining computed tomography (CT) and computational anatomy algorithms, to produce s...
Samsulrizal, Nurdiana Goh, Yong-Meng Ahmad, Hafandi Md Dom, Sulaiman Azmi, Nur Syimal’ain NoorMohamad Zin, Noor Syaffinaz Ebrahimi, Mahdi
Published in
Pharmaceutical Biology
Context Diabetes mellitus increases the risk of bone diseases including osteoporosis and osteoarthritis. We have previously demonstrated that Ficus deltoidea Jack (Moraceae) is capable of reducing hyperglycaemia. However, whether F. deltoidea could protect against diabetic osteoporosis remains to be determined. Objective The study examines the effe...
Anastasilakis, Athanasios D. Makras, Polyzois Yavropoulou, Maria P. Tabacco, Gaia Naciu, Anda Mihaela Palermo, Andrea
Published in
Journal of Clinical Medicine
Denosumab is a potent antiresorptive agent that substantially increases bone mineral density and reduces fracture rates at all skeletal sites for as long as it is administered. However, its favorable skeletal effects reverse quickly upon its discontinuation, because of a vast increase of osteoclast number and activity, which leads to a subsequent p...
Jang, Yuria Sohn, Hong Moon Ko, Young Jong Hyun, Hoon Lim, Wonbong
Published in
International Journal of Molecular Sciences
Background: Recently, it was reported that leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4, also called GPR48) is another receptor for RANKL and was shown to compete with RANK to bind RANKL and suppress canonical RANK signaling during osteoclast differentiation. The critical role of the protein triad RANK–RANKL in osteoclastogenes...
Saul, Dominik Kosinsky, Robyn Laura
Published in
International Journal of Molecular Sciences
Aging represents the multifactorial decline in physiological function of every living organism. Over the past decades, several hallmarks of aging have been defined, including epigenetic deregulation. Indeed, multiple epigenetic events were found altered across different species during aging. Epigenetic changes directly contributing to aging and agi...
Zhou, Shuwei Zhu, Lu You, Tian Li, Ping Shen, Hongrong He, Yewen Gao, Hui Yan, Luyou He, Zhuo Guo, Ying
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Published in
Quantitative Imaging in Medicine and Surgery
Background Osteoporosis is a common, progressive disease related to low bone mineral density (BMD). If it can be diagnosed at an early stage, osteoporosis is treatable. Quantitative computed tomography (QCT) is one of the current reference standards of BMD measurement, but dual-energy computed tomography (DECT) is considered to be a potential alter...
Ng, Jia-Sheng Chin, Kok-Yong
Published in
International Journal of Medical Sciences
Chronic psychological stress affects many body systems, including the skeleton, through various mechanisms. This review aims to provide an overview of the factors mediating the relationship between psychological stress and bone health. These factors can be divided into physiological and behavioural changes induced by psychological stress. The physi...