Truong, Kim M Pessah, Isaac N
Chlorantraniliprole (CP) and flubendiamide (FD) are widely used in agriculture globally to control lepidopteran pests. Both insecticides target ryanodine receptors (RyRs) and promote Ca2+ leak from sarcoplasmic reticulum (SR) within insect skeletal muscle yet are purportedly devoid of activity toward mammalian RyR1 and muscle. RyRs are ion channels...
Rodriguez-Salus, Melinda Bektas, Yasemin Schroeder, Mercedes Knoth, Colleen Vu, Trang Roberts, Philip Kaloshian, Isgouhi Eulgem, Thomas
Synthetic elicitors are drug-like compounds that induce plant immune responses but are structurally distinct from natural defense elicitors. Using high-throughput screening, we previously identified 114 synthetic elicitors that activate the expression of a pathogen-responsive reporter gene in Arabidopsis (Arabidopsis thaliana). Here, we report on t...
Jackson, David R Tu, Stephanie S Nguyen, MyChi Barajas, Jesus F Schaub, Andrew J Krug, Daniel Pistorius, Dominik Luo, Ray Müller, Rolf Tsai, Shiou-Chuan
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The incorporation of nonacetate starter units during type II polyketide biosynthesis helps diversify natural products. Currently, there are few enzymatic strategies for the incorporation of nonacetate starter units in type II polyketide synthase (PKS) pathways. Here we report the crystal structure of AuaEII, the anthranilate:CoA ligase responsible ...
Eudes, Aymerick Teixeira Benites, Veronica Wang, George Baidoo, Edward EK Lee, Taek Soon Keasling, Jay D Loqué, Dominique
Biological synthesis of pharmaceuticals and biochemicals offers an environmentally friendly alternative to conventional chemical synthesis. These alternative methods require the design of metabolic pathways and the identification of enzymes exhibiting adequate activities. Cinnamoyl, dihydrocinnamoyl, and benzoyl anthranilates are natural metabolite...
Bao, Duoduo Upadhyayula, Srigokul Larsen, Jillian M Xia, Bing Georgieva, Boriana Nuñez, Vicente Espinoza, Eli M Hartman, Joshua D Wurch, Michelle Chang, Andy
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Controlling charge transfer at a molecular scale is critical for efficient light harvesting, energy conversion, and nanoelectronics. Dipole-polarization electrets, the electrostatic analogue of magnets, provide a means for "steering" electron transduction via the local electric fields generated by their permanent electric dipoles. Here, we describe...
Wang, Yi Guo, Lei Qi, Suzhen Zhang, Hao Liu, Kechang Liu, Ruiquan Liang, Pei Casida, John E Liu, Shangzhong
Diamide insecticides with high efficacy against pests and good environmental safety are broadly applied in crop protection. They act at a poorly-defined site in the very complex ryanodine (Ry) receptor (RyR) potentially accessible to a fluorescent probe. Two N-propynyl analogs of the major anthranilic diamide insecticides chlorantraniliprole (Chlo)...
Coburn, C Allman, E Mahanti, P Benedetto, A Cabreiro, F Pincus, Z Matthijssens, F Araiz, C Mandel, A Vlachos, M
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For cells the passage from life to death can involve a regulated, programmed transition. In contrast to cell death, the mechanisms of systemic collapse underlying organismal death remain poorly understood. Here we present evidence of a cascade of cell death involving the calpain-cathepsin necrosis pathway that can drive organismal death in Caenorha...
Eudes, Aymerick Juminaga, Darmawi Baidoo, Edward EK Collins, F William Keasling, Jay D Loqué, Dominique
BackgroundOats contain hydroxycinnamoyl anthranilates, also named avenanthramides (Avn), which have beneficial health properties because of their antioxidant, anti-inflammatory, and antiproliferative effects. The microbial production of hydroxycinnamoyl anthranilates is an eco-friendly alternative to chemical synthesis or purification from plant so...
Gwanyanya, Asfree; Macianskiene, Regina; Bito, Virginie; 32850; Sipido, Karin; 11695; Vereecke, Johan; 2207; Mubagwa, Kanigula; 13293;
N-(p-amylcinnamoyl)anthranilic acid (ACA), a phospholipase A(2) (PLA(2)) inhibitor, is structurally-related to non-steroidal anti-inflammatory drugs (NSAIDs) of the fenamate group and may also modulate various ion channels. We used the whole-cell, patch-clamp technique at room temperature to investigate the effects of ACA on the Ca(2+)-activated ch...
Kao, J Tobis, J McClelland, RL Heaton, MR Davis, BR Holmes, DR Currier, JW Investigators in the Prevention of Reste...
Diabetic patients undergoing coronary interventions have worse clinical and angiographic outcomes than do patients without diabetes. Metformin, an insulin sensitizer, may decrease the occurrence of these outcomes. Diabetic patients in the Prevention of Restenosis with Tranilast and its Outcomes Trial were identified through their medical records (n...