Panoutsopoulos, Alexios A
Published in
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
In neuroscience research, the efforts to find the model through which we can mimic the in vivo microenvironment of a developing or defective brain have been everlasting. While model organisms are used for over a hundred years, many more methods have been introduced with immortalized or primary cell lines and later induced pluripotent stem cells and...
Chisholm, Timothy
Drug development is time consuming and expensive, partly due to the difficulty ofdetermining the safety and effectiveness of drugs in humans. To improve this process,there is a demand for models appropriate for studying the biological effects of drugsearly in their development. This article considers miniaturised organ technology toevaluate the saf...
Prasad, Minakshi Kumar, Rajesh Buragohain, Lukumoni Kumari, Ankur Ghosh, Mayukh
Published in
Frontiers in Cell and Developmental Biology
Engineered nanomaterials are bestowed with certain inherent physicochemical properties unlike their parent materials, rendering them suitable for the multifaceted needs of state-of-the-art biomedical, and pharmaceutical applications. The log-phase development of nano-science along with improved “bench to beside” conversion carries an enhanced proba...
Garagna, Silvia Cebral, Elisa Aréchaga, Juan Zuccotti, Maurizio
Published in
Frontiers in Cell and Developmental Biology
Liu, Qing Zhang, Linqing Zhu, Min-Sheng Wan, Guoqiang
Published in
Stem Cell Reports
Wan and colleagues report an optimized culture method for mouse cochlear organoids with over 6,000-fold increase in sample throughput. The authors show that both LGR5+ and LGR5–cochlear supporting cells can be differentiated into hair cells in the organoids. High-throughput screening of the organoids identified the VEGFR inhibitor regorafenib in pr...
Laube, Mandy Pietsch, Soeren Pannicke, Thomas Thome, Ulrich H. Fabian, Claire
Published in
Frontiers in Medicine
Preterm infants frequently suffer from pulmonary complications due to a physiological and structural lung immaturity resulting in significant morbidity and mortality. Novel in vitro and in vivo models are required to study the underlying mechanisms of late lung maturation and to facilitate the development of new therapeutic strategies. Organoids re...
Miloradovic, Dragana Pavlovic, Dragica Jankovic, Marina Gazdic Nikolic, Sandra Papic, Milos Milivojevic, Nevena Stojkovic, Miodrag Ljujic, Biljana
Published in
Frontiers in Cell and Developmental Biology
For a long time, animal models were used to mimic human biology and diseases. However, animal models are not an ideal solution due to numerous interspecies differences between humans and animals. New technologies, such as human-induced pluripotent stem cells and three-dimensional (3D) cultures such as organoids, represent promising solutions for re...
sapir, gal steinberg, daniel j. aqeilan, rami i. katz-brull, rachel
Organoids are a powerful tool in the quest to understand human diseases. As the developing brain is extremely inaccessible in mammals, cerebral organoids (COs) provide a unique way to investigate neural development and related disorders. The aim of this study was to utilize hyperpolarized 13C NMR to investigate the metabolism of COs in real-time, i...
Mohammadi, Sina Morell-Perez, Carolina Wright, Charles W. Wyche, Thomas P. White, Cory H. Sana, Theodore R. Lieberman, Linda A.
Published in
Stem Cell Reports
In this work, Lieberman and colleagues investigate donor-to-donor variability patterns using intestinal organoids from various donors. They show that developmental gene expression patterns, hormone secretion, and metabolic activity are consistent among multiple donors. Taken together, this article provides pathway and functional evidence for limite...
suckert, theresa nexhipi, sindi dietrich, antje koch, robin kunz-schughart, leoni a. bahn, emanuel beyreuther, elke
The number of proton therapy centers worldwide are increasing steadily, with more than two million cancer patients treated so far. Despite this development, pending questions on proton radiobiology still call for basic and translational preclinical research. Open issues are the on-going discussion on an energy-dependent varying proton RBE (relative...
