Wang, Honggen Yang, Ling Tan, Dong-Hang Fan, Wen-Xin Liu, Xu-Ge Wu, Jia-Qiang Huang, Zhi-Shu Li, Qingjiang
Published in
Angewandte Chemie (International ed. in English)
α-Haloboronates are useful organic synthons which can be converted to a diverse array of α-substituted alkyl borons. Methods to α-haloboronates are limiting and often suffer from harsh reaction conditions. Reported herein is a photochemical radical C-H halogenation of benzyl N -methyliminodiacetyl (MIDA) boronates. Fluorination, chlorination as wel...
Akama, Tsutomu Freund, Yvonne R. Berry, Pamela W. Carter, David S. Easom, Eric E. Jarnagin, Kurt Lunde, Christopher S. Plattner, Jacob J. Rock, Fernando Stefanakis, Rianna
...
Published in
ACS Infectious Diseases
A series of benzimidazole–benzoxaborole hybrid molecules linked via an amide linker are described that exhibit good in vitro activity against Onchocerca volvulus , a filarial nematode responsible for the disease onchocerciasis, also known as river blindness. The lead identified in this series, 8a (AN8799), was found to have acceptable pharmacokine...
Carter, David S. Jacobs, Robert T. Freund, Yvonne R. Berry, Pamela W. Akama, Tsutomu Easom, Eric E. Lunde, Christopher S. Rock, Fernando Stefanakis, Rianna McKerrow, James
...
Published in
ACS Infectious Diseases
The optimization of a series of benzimidazole–benzoxaborole hybrid molecules linked via a ketone that exhibit good activity against Onchocerca volvulus , a filarial nematode responsible for the disease onchocerciasis, also known as river blindness, is described. The lead identified in this series, 21 (AN15470), was found to have acceptable pharmaco...
Chen, Kai Huang, Xiongyi Zhang, Shuo-Qing Zhou, Andrew Z Kan, S B Jennifer Hong, Xin Arnold, Frances H
Published in
Synlett : accounts and rapid communications in synthetic organic chemistry
Previous work has demonstrated that variants of a heme protein, Rhodothermus marinus cytochrome c (Rma cyt c), catalyze abiological carbene boron-hydrogen (B-H) bond insertion with high efficiency and selectivity. Here we investigated this carbon-boron bondforming chemistry with cyclic, lactone-based carbenes. Using directed evolution, we obtained ...
Ganesh, Venkataraman Odachowski, Marcin Aggarwal, Varinder K
Published in
Angewandte Chemie (International ed. in English)
The enantiospecific coupling of secondary and tertiary boronic esters to aromatics has been investigated. Using p-lithiated phenylacetylenes and a range of boronic esters coupling has been achieved by the addition of N-bromosuccinimide (NBS). The alkyne functionality of the intermediate boronate complex reacts with NBS triggering the 1,2-migration ...
Farre, Albert Soares, Kaline Briggs, Rachel A Balanta, Angelica Benoit, David M Bonet, Amadeu
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
The generation of in situ sp2 -sp3 diboron adducts has revolutionised the synthesis of organoboranes. Organocatalytic diboration reactions have represented a milestone in terms of unpredictable reactivity of these adducts. However, current methodologies have limitations in terms of substrate scope, selectivity and functional group tolerance. Here a...
Lv, Wen-Xin Zeng, Yao-Fu Li, Qingjiang Chen, Yunyun Tan, Dong-Hang Yang, Ling Wang, Honggen
Published in
Angewandte Chemie (International ed. in English)
The synthesis of halogenated and trifluoromethylated α-boryl ketones via a one-pot oxidative difunctionalization of alkenyl MIDA boronates is reported. These novel densely functionalized organoborons bearing synthetically and functionally valuable carbonyl, halogen/CF3 and boronate moieties within the same molecule are synthetically challenging for...
Chen, Bin Nie, Han Hu, Rongrong Qin, Anjun Zhao, Zujin Tang, Ben-Zhong
Published in
Science China Chemistry
A series of new red fluorescent siloles consisting of a silole core and dimesitylboranyl substituent connected with a furan, thiophene, and selenophene bridges were synthesized and characterized. The optical properties, electronic structures, and electroluminescence (EL) performances were investigated. The emission wavelengths were red-shifted from...
Hatakeyama, Takuji Shiren, Kazushi Nakajima, Kiichi Nomura, Shintaro Nakatsuka, Soichiro Kinoshita, Keisuke Ni, Jingping Ono, Yohei Ikuta, Toshiaki
Published in
Advanced materials (Deerfield Beach, Fla.)
Ultrapure blue-fluorescent molecules based on thermally activated delayed fluorescence are developed. Organic light-emitting diode (OLED) devices employing the new emitters exhibit a deep blue emission at 467 nm with a full-width at half-maximum of 28 nm, CIE coordinates of (0.12, 0.13), and an internal quantum efficiency of ≈100%, which represent ...
Wang, Liqiong Day, Cynthia S Wright, Marcus W Welker, Mark E
Published in
Beilstein journal of organic chemistry
A 2-diethanolamine boronyl substituted 1,3-diene has been synthesized in high yield and characterized spectroscopically as well as by X-ray crystallography. This diene has then subsequently been used in a number of fast, high yielding Diels-Alder/cross coupling reactions.
