Gadji, Macoura Mathur, Shubha Bélanger, Brigitte Jangamreddy, Jaganmohan Reddy Lamoureux, Josée Tsanaclis, Ana Maria Crous Fortin, David Drouin, Régen Mai, Sabine
Published in
International journal of molecular sciences
Mechanisms of recurrence in oligodendrogliomas are poorly understood. Recurrence might be driven by telomere dysfunction-mediated genomic instability. In a pilot study, we investigated ten patients with oligodendrogliomas at the time of diagnosis (first surgery) and after recurrence (second surgery) using three-dimensional nuclear telomere analysis...
Ball, Matthew K Kollmeyer, Thomas M Praska, Corinne E McKenna, Michelle L Giannini, Caterina Raghunathan, Aditya Jentoft, Mark E Lachance, Daniel H Kipp, Benjamin R Jenkins, Robert B
...
Published in
Neuro-oncology Advances
Background Oligodendroglioma is genetically defined by concomitant IDH ( IDH1/IDH2 ) mutation and whole-arm 1p/19q codeletion. Codeletion of 1p/19q traditionally evaluated by fluorescence in situ hybridization (FISH) cannot distinguish partial from whole-arm 1p/19q codeletion. Partial 1p/19q codeletion called positive by FISH is diagnostically a “f...
Fabian, Constantin Watson, Joe C
Published in
Cureus
Stereotactic navigation and functional magnetic resonance imaging (fMRI) are increasingly used as important tools for intraoperative guidance and preoperative mapping for lesions in eloquent areas. We report a case in which a WHO grade II oligodendroglioma in Broca’s area with functional activation was successfully resected with the support of bloo...
Mirchia, Kanish Richardson, Timothy E.
Published in
Cancers
Diffuse gliomas are among the most common adult central nervous system tumors with an annual incidence of more than 16,000 cases in the United States. Until very recently, the diagnosis of these tumors was based solely on morphologic features, however, with the publication of the WHO Classification of Tumours of the Central Nervous System, revised ...
Haapasalo, Joonas Nordfors, Kristiina Haapasalo, Hannu Parkkila, Seppo
Published in
Cancers
Carbonic anhydrases (CAs) are zinc-containing metalloenzymes that participate in the regulation of pH homeostasis in addition to many other important physiological functions. Importantly, CAs have been associated with neoplastic processes and cancer. Brain tumors represent a heterogeneous group of diseases with a frequently dismal prognosis, and ne...
van Lent, Djuno I van Baarsen, Kirsten M Snijders, Tom J Robe, Pierre A J T
Published in
Neuro-oncology Advances
Background Isocitrate dehydrogenase (IDH) mutation and 1p/19q-codeletion are oncogenetic alterations with a positive prognostic value for diffuse gliomas, especially grade II and III. Some studies have suggested differences in biological behavior as reflected by radiological characteristics. In this paper, the literature regarding radiological char...
Zhang, Sarah William, Christopher
Published in
Academic pathology
The following fictional cases are intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional...
Neagoe, Mariana-Alis
Published in
Acta Medica Transilvanica
The migraine is among the most frequent complains of the patients requesting a medical consultation. I am presenting hereby the case of a 34-year old patient, who complained of diffuse migraine followed several weeks later by vomiting and seizures. The brain computed tomography (CT) and magnetic resonance imaging (MRI) examinations indicate an intr...
Fu, Weilun Wang, Wenjing Li, Hao Jiao, Yuming Weng, Jiancong Huo, Ran Yan, Zihan Wang, Jie Xu, Hongyuan Wang, Shuo
...
Published in
Frontiers in Oncology
The tumor immune microenvironment (TIME) plays a pivotal role in tumor development, progression, and prognosis. However, the characteristics of the TIME in diffuse astrocytoma (DA) are still unclear. Leveraging mass cytometry with a panel of 33 markers, we analyzed the infiltrating immune cells from 10 DA and 4 oligodendroglioma (OG) tissues and pr...
SUZUKI, Hime MIKUNI, Nobuhiro SUGITA, Shintaro AOYAMA, Tomoyuki YOKOYAMA, Rintaro SUZUKI, Yuto ENATSU, Rei AKIYAMA, Yukinori MIKAMI, Takeshi WANIBUCHI, Masahiko
...
Published in
Neurologia medico-chirurgica
Diffuse astrocytic and oligodendroglial tumors are frequently associated with symptomatic epilepsy, and predictive seizure control is important for the improvement of patient quality of life. To elucidate the factors related to drug resistance of brain tumor-associated epilepsy from a pathological perspective. From January 2012 to October 2017, 36 ...
