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with oligoclonal IgG as keyword
Hannich, Malte J. Konen, Franz F. Gag, Konrad Alkhayer, Aiham Türker, Seda N. Budde, Kathrin Nauck, Matthias Wurster, Ulrich Dressel, Alexander Skripuletz, Thomas
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Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Oligoclonal bands (OCB) analysis is the reference standard for detecting an intrathecal IgG synthesis. Alongside OCB, free light chains kappa (FLCκ) are considered an additional sensitive biomarker for determining patterns 2 or 3, indicating intrathecal Ig synthesis. However, kFLC IF is not suitable for detecting a monoclonal pattern 5. ...
süße, marie konen, franz felix schwenkenbecher, philipp budde, kathrin nauck, matthias grothe, matthias hannich, malte johannes skripuletz, thomas
Free light chains kappa (FLCκ) in cerebrospinal fluid (CSF) are a part of the intrathecal immune response. This observational study was conducted to investigate the effects of different disease-modifying therapies (DMT) on the humoral intrathecal immune response in the CSF of patients with multiple sclerosis (MS). FLCκ were analyzed in CSF and seru...
Zeman, David Kušnierová, Pavlína Bartoš, Vladimír Hradílek, Pavel Kurková, Barbora Zapletalová, Olga
Published in
Annals of clinical biochemistry
The results of free light chains quantitation in the cerebrospinal fluid were recently compared with the presence of cerebrospinal fluid-restricted oligoclonal IgG, but not oligoclonal free kappa light chains and oligoclonal free lambda light chains. We therefore aimed to compare the performance of the quantitative tests with the qualitative one fo...
Presslauer, S. Milosavljevic, D. Brücke, T. Bayer, P. Hübl, W.
Published in
Journal of Neurology
BackgroundNumerous studies have demonstrated elevated kappa free light chains (KFLCs) in CSF of multiple sclerosis (MS) patients. However, so far only small cohorts have been examined, and generally only through qualitative KFLCs analysis. Using a recently developed free light chain (FLC) immunoassay, it is now possible to quantitatively measure KF...