Publication search
with oat1 as keyword
Li, Julia G.
Organic anion transporter 1 (OAT1) and 3 (OAT3) are multi-specific renal drug transporters that facilitate the uptake and clearance of a wide range of endogenous and exogenous molecules. While they’ve been extensively studied for their clinical role in drug disposition and potential drug-drug interactions (DDIs), their physiological role in regulat...
Naranjo, Leopoldo Lamas-Maceiras, Mònica Ullán, Ricardo V. Campoy, Sonia Teijeira, Fernando Casqueiro, Javier Martín, Juan F.
Published in
Molecular Genetics and Genomics
The Penicillium chrysogenumoat1 gene, which encodes a class III ω-aminotransferase, was cloned and characterized. This enzyme converts lysine into 2-aminoadipic semialdehyde, and plays an important role in the biosynthesis of 2-aminoadipic acid, a precursor of penicillin and other β-lactam antibiotics. The enzyme is related to ornithine-5-aminotran...
