Sun, Xiao-Li Ma, Li-Na Chen, Zhen-Zhu Xiong, Yan-Bing Jia, Jiao Wang, Yu Ren, Yan
Published in
Frontiers in Psychiatry
Objective Bipolar disorder (BD) and major depressive disorder (MDD) are two common psychiatric disorders. Due to the overlapping clinical symptoms and the lack of objective diagnostic biomarkers, bipolar disorder (BD) is easily misdiagnosed as major depressive disorder (MDD), which in turn affects treatment decisions and prognosis. This study aimed...
Sha'aban, Abubakar Zainal, Hadzliana Khalil, Nor Azlina Abd Aziz, Fatimatuzzahra' Ch'ng, Ewe Seng Teh, Chin-Hoe Mohammed, Mustapha Ibrahim, Baharudin
Published in
Molecules (Basel, Switzerland)
Low-dose aspirin (LDA) is the backbone for secondary prevention of coronary artery disease, although limited by gastric toxicity. This study aimed to identify novel metabolites that could predict LDA-induced gastric toxicity using pharmacometabolomics. Pre-dosed urine samples were collected from male Sprague-Dawley rats. The rats were treated with ...
Novaes, Fábio Junior Moreira de Faria, Daliane Cláudia Ferraz, Fabio Zamboni de Aquino Neto, Francisco Radler
Published in
Plants (Basel, Switzerland)
In many analytical chemical procedures, organic solvents are required to favour a better global yield upon the separation, extraction, or isolation of the target phytochemical analyte. The selection of extraction solvents is generally based on the solubility difference between target analytes and the undesired matrix components, as well as the over...
Melchiorre, Giulia Giustiniano, Francesco Rathore, Sundeep Pileio, Giuseppe
Published in
Frontiers in Chemistry
In this study, long-lived nuclear singlet order methods are combined with diffusion tensor imaging with the purpose of characterizing the full diffusion tensor of molecules diffusing freely in large pores of up to a millimeter in size. Such sizes are out of reach in conventional diffusion tensor imaging because of the limitations imposed by the rel...
Mineev, Konstantin S; Chernykh, Mikhail A; Motov, Vladislav V; Prudnikova, Daria A; Pavlenko, Daniil M; Kuzmenkov, Alexey I; Peigneur, Steve; 56122; Tytgat, Jan; 18354; Vassilevski, Alexander A;
Scorpion α-toxins (α-NaTx) inhibiting the inactivation of voltage-gated sodium channels (Nav ) are a well-studied family of small proteins. We previously showed that the structure of α-NaTx specificity module responsible for selective Nav binding is governed by an interplay between the nest and niche protein motifs. Here, we report the solution str...
Grandori, Rita
Published in
Frontiers in Biophysics
Proteins carry out their biological activity as dynamic structures and populate in solution or in biological membranes structural distributions with different degrees of heterogeneity. The central challenge in structural biology is to capture protein structural dynamics under equilibrium or kinetic conditions shifting from single, static pictures t...
Yang, Ruoyu Wang, Yi Yuan, Chunhua Shen, Xunzhang Cai, Ming Wang, Liyan Hu, Jingyun Song, Haihan Wang, Hongbiao Zhang, Lei
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Published in
Frontiers in Physiology
Objective: The purpose of this study was to employ metabolomics for the analysis of urine metabolites in swimmers, with the aim of establishing models for assessing their athletic status and competitive potential. Furthermore, the study sought to compare the identification efficacy of multi-component (urine and blood) model versus single-component ...
Madrid-Gambin, Francisco Oller, Sergio Marco, Santiago Pozo, Óscar J. Andres-Lacueva, Cristina Llorach, Rafael
Published in
Frontiers in Molecular Biosciences
Introduction: There is evidence that sample treatment of blood-based biosamples may affect integral signals in nuclear magnetic resonance-based metabolomics. The presence of macromolecules in plasma/serum samples makes investigating low-molecular-weight metabolites challenging. It is particularly relevant in the targeted approach, in which absolute...
Chen, Honghai Ding, Zenan Dai, Tao Lin, Jianzhong Xu, Dunming Xia, Feng Feng, Jianghua Shen, Guiping
Published in
Journal of the science of food and agriculture
The market demand for Panax notoginseng (P. notoginseng) is growing rapidly because of its useful properties in food and medicine. However, the frequent adulteration of P. notoginseng seriously affects the health of consumers and is a great challenge to food safety. In this study, low- and high-field nuclear magnetic resonance (LF/HF-NMR) were appl...
Wu, Mengxing Xu, Weilin Fei, Yinjiao Li, Yurong Yuan, Jinling Qiu, Lei Zhang, Yumeng Chen, Guanhua Cheng, Yu Cao, Yuandong
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Published in
Frontiers in Oncology
Objective Tumor residue after concurrent chemoradiotherapy (CCRT) in nasopharyngeal carcinoma (NPC) patients often predicts poor prognosis. Thus, the objective of this retrospective study is to develop a nomogram that combines magnetic resonance (MRI) radiomics features and clinical features to predict the early response of locally advanced nasopha...
