Miyasaka, Yuhei Komatsu, Shuichiro Abe, Takanori Kubo, Nobuteru Okano, Naoko Shibuya, Kei Shirai, Katsuyuki Kawamura, Hidemasa Saitoh, Jun-Ichi Ebara, Takeshi
...
Published in
Cancers
Lung cancer is a leading cause of cancer-related deaths worldwide. Radiotherapy is an essential treatment modality for inoperable non-small cell lung cancer (NSCLC). Stereotactic body radiotherapy (SBRT) is the standard treatment for early-stage NSCLC because of its favorable local control (LC) compared to conventional radiotherapy. Carbon ion radi...
Rallis, Kathrine S Lai Yau, Thomas Ho Sideris, Michail
Published in
Anticancer research
Chemoradiotherapy (CRT) refers to the combined administration of both chemotherapy and radiotherapy as an anticancer treatment. Over the years, CRT has become an established treatment for a diverse range of locally advanced solid tumours. The rationale for CRT is based on the two concepts of spatial cooperation and in-field cooperation, whereby the...
Shang, Jia-Lin Ning, Shao-Bo Chen, Ying-Yi Chen, Tian-Xiang Zhang, Jian
Published in
Acta pharmacologica Sinica
Sirtuin 6 (SIRT6), a member of the sirtuin family, is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that is involved in various physiological and pathological processes. SIRT6 is generally downregulated and linked to tumorigenesis in non-small cell lung carcinoma (NSCLC), thus regarded as a promising therapeutic target of NSCLC. ...
Liu, Yu-Chang Huang, Bo-Han Chung, Jing-Gung Liu, Wei-Lin Hsu, Fei-Ting Lin, Song-Shei
Published in
Anticancer research
Non-small cell lung cancer (NSCLC) is a serious disease and the leading cause of death globally. Overexpression of protein kinase B/nuclear factor-kappa B (NF-κB) signaling transduction of NSCLC cells was recognized as a potential therapeutic target. Lenvatinib is a multiple kinase inhibitor against vascular endothelial growth factor receptor famil...
Nieder, Carsten Imingen, Kristian S Mannsaker, Bard Yobuta, Rosalba
Published in
Anticancer research
Recent studies suggested that target volume size impacts survival in patients with non-small cell lung cancer (NSCLC) receiving radical radiotherapy. Little is known about the impact of target volume size in palliative radiotherapy or chemoradiotherapy. Therefore, we analyzed the overall survival stratified for clinical and planning target volume (...
Karpuz, Merve Silindir-Gunay, Mine Ozer, A Yekta Ozturk, Suleyman Can Yanik, Hamdullah Tuncel, Murat Aydin, Cisel Esendagli, Gunes
Published in
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
NSCLC is the most common type of lung cancer. However, non-specific contrast agents, radiopharmaceuticals, and treatment methods are insufficient in early diagnosis and eradication of all tumor tissue. Therefore, the formulation of a novel, targeted, specific theranostic agents possess critical importance. In our previous study, paclitaxel and vino...
Liang, Qian Gu, Wei-Ming Huang, Ke Luo, Ming-Yu Zou, Jing-Hua Zhuang, Guang-Lei Lei, Hui-Min Chen, Hong-Zhuan Zhu, Liang Zhou, Lu
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Published in
Acta pharmacologica Sinica
Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as erlotinib, remains a major challenge in the targeted therapy of non-small cell lung cancer (NSCLC). HKB99 is a novel allosteric inhibitor of phosphoglycerate mutase 1 (PGAM1) that preferentially suppresses cell proliferation and induces more apop...
Nishii, Kazuya Ohashi, Kadoaki Tamura, Tomoki Ninomiya, Kiichiro Matsubara, Takehiro Senoo, Satoru Kano, Hirohisa Watanabe, Hiromi Oda, Naohiro Makimoto, Go
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The detection of certain oncogenic driver mutations, including those of epidermal growth factor receptor (EGFR), is essential for determining treatment strategies for advanced non‑small cell lung cancer (NSCLC). The current study assessed the feasibility of testing exhaled breath condensate (EBC) for EGFR mutations by droplet digital PCR (ddPCR). S...
Pang, Lizhi Shah, Harshit Wang, Hongzhi Shu, Dan Qian, Steven Y Sathish, Venkatachalem
Published in
Molecular therapy. Nucleic acids
Knocking down delta-5-desaturase (D5D) expression by D5D small interfering RNA (siRNA) has been reported that could redirect the cyclooxygenase-2 (COX-2)-catalyzed dihomo-γ-linolenic acid (DGLA) peroxidation from producing prostaglandin E2 to 8-hydroxyoctanoic acid (8-HOA), resulting in the inhibition of colon and pancreatic cancers. However, the e...
De Chiara, Loretta Leiro-Fernandez, Virginia Rodríguez-Girondo, Mar Valverde, Diana Botana-Rial, María Isabel Fernández-Villar, Alberto
Published in
International journal of molecular sciences
Different methodological approaches are available to assess DNA methylation biomarkers. In this study, we evaluated two sodium bisulfite conversion-dependent methods, namely pyrosequencing and methylation-specific qPCR (MS-qPCR), with the aim of measuring the closeness of agreement of methylation values between these two methods and its effect when...
