Jiang, Yuan Song, Shasha Liu, Jingxin Zhang, Liyuan Guo, Xiaofei Lu, Jiayao Li, Lie Yang, Chao Fu, Qiang Zeng, Bin
...
Published in
Frontiers in Immunology
Pulmonary arterial hypertension (PAH) is a severe progressive disease that may cause early right ventricular failure and eventual cardiac failure. The pathogenesis of PAH involves endothelial dysfunction, aberrant proliferation of pulmonary artery smooth muscle cells (PASMCs), and vascular fibrosis. Hypoxia has been shown to induce elevated secreti...
Fan, Kejing Ferguson, Brett James Muñoz, Nacira Belen Li, Man-Wah Lam, Hon-Ming
Published in
Frontiers in Plant Science
Mohaupt, Pablo Roucou, Xavier Delaby, Constance Vialaret, Jérôme Lehmann, Sylvain Hirtz, Christophe
Published in
Frontiers in Cellular Neuroscience
Translation involves the biosynthesis of a protein sequence following the decoding of the genetic information embedded in a messenger RNA (mRNA). Typically, the eukaryotic mRNA was considered to be inherently monocistronic, but this paradigm is not in agreement with the translational landscape of cells, tissues, and organs. Recent ribosome sequenci...
Yang, Yu-Shen He, Shi-Ling Chen, Wei-Can Wang, Cong-Mei Huang, Qiao-Mei Shi, Yan-Chuan Lin, Shu He, He-fan
Published in
Frontiers in Cellular Neuroscience
Postoperative cognitive dysfunction (POCD), especially in elderly patients, is a serious complication characterized by impairment of cognitive and sensory modalities after surgery. The pathogenesis of POCD mainly includes neuroinflammation, neuronal apoptosis, oxidative stress, accumulation of Aβ, and tau hyperphosphorylation; however, the exact me...
Jiang, Yanan Luo, Kunpeng Xu, Jincheng Shen, Xiuyun Gao, Yang Fu, Wenqi Zhang, Xuesong Wang, Hongguang Liu, Bing
Published in
Frontiers in Oncology
Background Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. Non-coding RNAs play an important role in HCC. This study aims to identify a senescence-related non-coding RNA network-based prognostic model for individualized therapies for HCC. Methods HCC subtypes with senescence status were identified o...
Han, Zeping Chen, Huafang Guo, Zhonghui Shen, Jian Luo, Wenfeng Xie, Fangmei Wan, Yu Wang, Shengbo Li, Jianhao He, Jinhua
...
Published in
Frontiers in Oncology
As a novel class of endogenous non-coding RNAs discovered in recent years, circular RNAs (circRNAs) are highly conserved and stable covalently closed ring structures with no 5′-end cap or 3′-end poly(A) tail. CircRNAs are formed by reverse splicing, mainly by means of a noose structure or intron complementary pairing. Exosomes are tiny discoid vesi...
Liu, Wanting He, Qing-Yu Brunet, Marie A.
Published in
Frontiers in Cell and Developmental Biology
Gowthaman, Uthra Ivanov, Maxim Schwarz, Isabel Patel, Heta P Müller, Niels A García-Pichardo, Desiré Lenstra, Tineke L Marquardt, Sebastian
Published in
The EMBO journal
Nucleosome-depleted regions (NDRs) at gene promoters support initiation of RNA polymerase II transcription. Interestingly, transcription often initiates in both directions, resulting in an mRNA and a divergent non-coding (DNC) transcript of unclear purpose. Here, we characterized the genetic architecture and molecular mechanism of DNC transcription...
Choi, Sangyong Sathe, Adwait Mathé, Ewy Xing, Chao Pan, Zui
Published in
Frontiers in Oncology
Abnormal genetic and epigenetic modifications play a key role in esophageal cancer. By Assay for Transposase-Accessible Chromatin by sequencing (ATAC-seq), this study compared chromatin accessibility landscapes among two esophageal squamous cell carcinoma (ESCC) cell lines, KYSE-30 and KYSE-150, and a non-cancerous esophageal epithelial cell line, ...
Rosa, Alessandro Ciaudo, Constance Sumazin, Pavel Fazi, Francesco
Published in
Frontiers in Cell and Developmental Biology
